[1]陈建玲,潘延平△.甘露醇及6-氨基己酸治疗蛛网膜下腔出血疗效及安全性研究*[J].陕西医学杂志,2020,49(7):871-873.[doi:DOI:10.3969/j.issn.10007377.2020.07.028]
　CHEN Jianling,PAN Yanping..Efficacy and safety of mannitol and 6-aminoacetic acid in treatment of subarachnoid hemorrhage[J].,2020,49(7):871-873.[doi:DOI:10.3969/j.issn.10007377.2020.07.028]
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甘露醇及6-氨基己酸治疗蛛网膜下腔出血疗效及安全性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年7期
页码:
871-873
栏目:
药物与临床
出版日期:
2020-07-05

文章信息/Info

Title:
Efficacy and safety of mannitol and 6-aminoacetic acid in treatment of subarachnoid hemorrhage
作者:
陈建玲1; 潘延平2△
1.西安医学院第二附属医院急诊科(西安 710038); 2.陕西省韩城市人民医院神经内科(韩城 715400)
Author(s):
CHEN Jianling; PAN Yanping.
Department of Emergency,the Second Affiliated Hospital of Xi'an Medical University(Xi'an 710038)
关键词:
甘露醇;  6-氨基己酸;  蛛网膜下腔出血;  血流速度;  对比研究
Keywords:
Mannitol;  6-Aminoacetic acid;  Subarachnoid hemorrhage;  Blood flow velocity;  Comparative study
分类号:
R743
DOI:
DOI:10.3969/j.issn.10007377.2020.07.028
文献标志码:
A
摘要:
目的:探讨甘露醇及6-氨基己酸治疗蛛网膜下腔出血的疗效及安全性。方法:选取96例蛛网膜下腔出血患者,按照随机原则,将其分为研究组和对照组,每组患者48例,对照组患者采取6-氨基己酸治疗,研究组患者采取甘露醇及6-氨基己酸治疗,对比两组患者的疗效及安全性。结果:两组患者在治疗前 NIHSS 评分、差异无统计学意义(P>0.05),治疗后,两组患者的神经功能、颅内压均有所改善,其中研究组患者的改善程度较对照组明显(P<0.05); 两组患者治疗前、治疗后3 d脑组织中动脉血流速度对比差异无统计学意义(P>0.05),治疗7 d、14 d后,研究组患者脑组织中动脉血流速度明显低于对照组(P<0.05); 研究组患者的治疗有效率明显高于对照组(P<0.05)。结论:甘露醇及6-氨基己酸治疗蛛网膜下腔出血疗效要优于单用6-氨基己酸治疗,可改善神经功能,降低颅内压,安全性好。
Abstract:
Objective:To explore the efficacy and safety of mannitol and 6-aminoacetic acid in the treatment of subarachnoid hemorrhage. Methods:A total of 96 patients with subarachnoid hemorrhage were selected and randomly divided into study group and control group,with 48 patients in each group. The control group was treated with 6-aminoacetic acid. The study group was treated with mannitol and 6-aminoacetic acid. The efficacy and safety were compared between the two groups. Results:There was no statistical difference in NIHSS score between the two groups(P>0.05). After treatment,the neurological function and intracranial pressure of the two groups were improved,and the improvement degree of the study group was significantly higher than that of the control group(P<0.05). There was no statistically significant difference in arterial blood flow velocity in brain between the two groups before and 3 days after treatment(P>0.05). After 7 and 14 days of treatment,the arterial blood flow velocity in brain in the study group was significantly lower than that of the control group(P<0.05). The effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05). Conclusion:The efficacy of mannitol and 6-aminoacetic acid in the treatment of subarachnoid hemorrhage is better than that of 6-aminoacetic acid alone. It can improve nerve function,reduce intracranial pressure,and has good safety.

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备注/Memo

备注/Memo:
*陕西省自然科学基础研究项目(2017JM8146)
更新日期/Last Update: 2020-07-28