[1]何洪标,梁俏敏,郑曙光.结直肠锯齿状息肉病相关通道蛋白表达水平对患者病情的影响*[J].陕西医学杂志,2020,49(6):679-682.[doi:DOI:10.3969/j.issn.10007377.2020.06.010]
　HE Hongbiao,LIANG Qiaomin,ZHEGN Shuguang..Effect of colorectal serrated polyposis related channel protein expression level on patients' condition[J].,2020,49(6):679-682.[doi:DOI:10.3969/j.issn.10007377.2020.06.010]
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结直肠锯齿状息肉病相关通道蛋白表达水平对患者病情的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年6期
页码:
679-682
栏目:
临床研究
出版日期:
2020-06-05

文章信息/Info

Title:
Effect of colorectal serrated polyposis related channel protein expression level on patients' condition
作者:
何洪标; 梁俏敏; 郑曙光
广东省中山市陈星海医院(中山 5281415)
Author(s):
HE Hongbiao; LIANG Qiaomin; ZHEGN Shuguang.
Chenxinghai Hospital,Zhongshan City,Guangdong Province(Zhongshan 5281415)
关键词:
结直肠;  锯齿状息肉病;  通道蛋白;  病情特征;  疾病诊断;  临床分期
Keywords:
Colorectun;  Serrated polyposis;  Channel protein;  Disease characteristics;  Disease diagnnosis;  Clinical stage
分类号:
R656
DOI:
DOI:10.3969/j.issn.10007377.2020.06.010
文献标志码:
A
摘要:
目的:探讨结直肠锯齿状息肉病相关通道蛋白表达水平对患者病情的影响。方法:对85例结直肠锯齿状息肉病患者(疾病组)及85例健康居民(健康组)进行调查研究,分析健康组和疾病组通道蛋白(P-gP、Survivin、HSP70、EHD2)检出情况的统计学差异,比较不同情况或病情(性别、年龄、息肉直径、分化程度、浸润深度、临床分期)疾病组患者四种通道蛋白检出情况的统计学差异。结果:疾病组患者四种通道蛋白(P-gP、Survivin、HSP70、EHD2)检出率均高于对照组,差异均有统计学意义(P<0.05)。P-gP检出情况比较,性别、年龄、息肉直径、分化程度、浸润深度、临床分期对其影响有统计学意义(P<0.05)。Survivin检出情况比较,年龄、息肉直径、浸润深度、临床分期对其影响有统计学意义(P<0.05)。HSP70检出情况比较,性别、分化程度对其影响有统计学意义(P<0.05)。EHD2检出情况比较,年龄对其影响有统计学意义(P<0.05)。 结论:P-gP、Survivin、HSP70、EHD2四种通道蛋白检测对疾病诊断及病情评估具有较好的临床实用价值。
Abstract:
Objective:To investigate the effect of colorectal serrated polyposis related channel protein expression level on patients' condition.Methods:85 cases of patients with colorectal serrated polyps(disease group)and 85 cases of healthy residents(healthy group)were investigated.The difference of four channel proteins(P-gP,Survivin,HSP70,EHD2)between healthy group and disease group was analyzed.The detection results of four channel proteins in patients with different conditions(gender,age,polyp diameter,degree of differentiation,depth of infiltration,clinical stage)were compared.Results:The detection rate of four channel proteins(P-gP,Survivin,HSP70,EHD2)in the disease group was higher than that in the control group,and the difference was statistically significant(P<0.05).In terms of P-gP,gender,age,polyp diameter,degree of differentiation,depth of infiltration and clinical stage had statistical significant differences(P<0.05).In terms of Survivin,age,polyp diameter,depth of infiltration and clinical stage had statistical significant differences(P<0.05).In terms of HSP70,gender and degree of differentiation had statistical significant differences(P<0.05).In terms of EHD2,age had statistical significant difference(P<0.05).Conclusion:The detection of P-gP,Survivin,HSP70 and EHD2 has good clinical value in diagnosis and evaluation of disease.

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相似文献/References:

[1]史 璇,张 鑫,朱金朋,等.结直肠腺癌组织中CYR61和血管内皮生长因子的表达及相关性研究*[J].陕西医学杂志,2019,(4):421.
　SHI Xuan,ZHANG Xin,ZHU Jinpeng,et al.Expressions and relationship of CYR61 and VEGF in colorectal adenocarcinoma[J].,2019,(6):421.

备注/Memo

备注/Memo:
*广东省中山市卫生健康局医学科研项目(2019A020093)
更新日期/Last Update: 2020-07-28