[1]王双龙,吕 镔△,李 龙,等.超声造影参数成像在甲状腺微小乳头状癌鉴别诊断中的应用价值*[J].陕西医学杂志,2020,49(5):599-602.
　WANG Shuanglong,LV Bin,LI Long,et al.The value of parametric imaging of contrast-enhanced ultrasound in differential diagnosis of papillary thyroidmicrocarcinoma[J].,2020,49(5):599-602.
点击复制

超声造影参数成像在甲状腺微小乳头状癌鉴别诊断中的应用价值*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年5期
页码:
599-602
栏目:
临床研究
出版日期:
2020-05-05

文章信息/Info

Title:
The value of parametric imaging of contrast-enhanced ultrasound in differential diagnosis of papillary thyroidmicrocarcinoma
文章编号:
DOI:10.3969/j.issn.10007377.2020.05.024
作者:
王双龙; 吕 镔△; 李 龙; 马香玲; 赵 蕊; 高小红; 庞 慧
山东省济宁市第一人民医院超声科(济宁 272011)
Author(s):
WANG Shuanglong; LV Bin; LI Long; et al.
Department of Ultrasound,the First People's Hospital of Jining,Shandong Province(Jining 272011)
关键词:
甲状腺结节;  甲状腺微小乳头状癌;  诊断;  超声造影;  时间强度曲线;  定量参数
Keywords:
Thyroid nodule;  Papillary thyroid microcarcinoma;  Diagnosis;  Contrast-enhanced ultrasound;  Time-activity curve;  Quantitative parameters
分类号:
R445.1
文献标志码:
A
摘要:
目的:探讨超声造影(CEUS)参数成像在甲状腺微小乳头状癌(PTMC)鉴别诊断中的应用价值。方法:回顾性分析经手术切除的60个甲状腺结节(最大径≤1.0 cm)的超声造影资料,用QontraXt软件定量分析结节灌注峰值(Peak)、达峰时间(TP)、灌注率(Shapness)、曲线下面积(AUC); 据手术病理结果分为良性组(n=28)和恶性组(n=32),分析CEUS参数在PTMC鉴别诊断中的价值。结果:超声造影定量分析结果显示,恶性组Peak、AUC显著小于良性组,两组比较差异有统计学意义(P<0.05); TP、Shapness良恶性组之间比较差异无统计学意义(P>0.05)。Peak、AUC诊断PTMC的ROC曲线下面积分别为0.819和0.738,最佳截断值(Cutoff值)分别为50.25和9.5; Peak诊断PTMC的敏感性、准确度高于AUC。结论:CEUS参数成像在PTMC的鉴别诊断中具有重要价值,其中Peak的价值最大,可作为鉴别PTMC的重要参考指标。
Abstract:
Objective:To investigate the value of parametric imaging of contrast-enhanced ultrasound(CEUS)in differential diagnosis of papillary thyroid microcarcinoma(PTMC). Methods:The CEUS data of 60 thyroid nodules(maximum diameter<1.0 cm)via surgical resection were retrospectively analyzed. The Peak,the time to peak(TP),the Shapness,the area under the curve(AUC)of nodules were quantitatiely analyzed by QontraXt software. According to the pathological results of surgery,the nodules were divided into benign group(n=28)and malignant group(n=32). Results:Peak and AUC were significantly lower in malignant group than those in benign group,and the difference was statistically significant(P<0.05). There was no statistically significant difference in TP and Shappness between benign group and malignant group(P>0.05). The area under the ROC curve of Peak and AUC in diagnosing PTMC were respectively 0.819 and 0.738,the best cutoff value were respectively 50.25 and 9.50. The sensitivity and accuracy of Peak in diagnosing PTMC were higher than AUC. Conclusion:The parametric imaging of CEUS has important value in the differential diagnosis of PTMC,among which Peak has the best value and can be used as an important reference index.

参考文献/References:

[1] 张于芝,丁文波,武心萍,等.临床超声及细胞病理学特征对甲状腺微小乳头状癌中央区淋巴结转移的预测价值[J].中国超声医学杂志,2017,33(7):964-967.
[2] Miyauchi A,Ito Y,Oda H.Insights into the management of pap-illary micmcarcinoma of the thyroid[J].Thyroid,2018,28(1):23-31.
[3] 侯春杰,汤靖岚,何洪峰,等. 甲状腺微小乳头状癌的多学科综合预测模型建立[J].中国超声医学杂志,2019,35(8):680-683.
[4] 中国抗癌协会甲状腺癌专业委员会(CATO).甲状腺微小乳头状癌诊断与治疗中国专家共识(2016版)[J].中国肿瘤临床,2016,43(10):405-411.
[5] 赵 鹏,任 敏,杜国庆,等.超声造影在评价依达拉奉改善骨骼肌缺血再灌注损伤中的应用价值[J].中华超声影像学杂志,2017,26(3):264-268.
[6] 陈 瑛,于明安,闫 娟,等. 超声造影对不同大小甲状腺结节良恶性诊断价值[J]. 陕西医学杂志,2017,46(4):446-450.
[7] Yang D,Li R,Zhang XH,et al.Perfusion characteristics of hepatocellular carcinoma at contrast-enhanced ultrasound:influence of the cellular differentiation,the tumor size and the underlying hepatic condition[J].Sci Rep,2018,8(1):4713.
[8] Baur ADJ,Schwabe J,Rogasch J,et al.A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness [J].Eur Radiol,2018,28(5):1949-1960.
[9] Zhao J,Zhang J,Zhu QL,et al.The value of contrast-enhanced ultrasound for sentinel lymph node identification and characterisation in pre-operative breast cancer patients:a prospective study[J].Eur Radiol,2018,28(4):1654-1661.
[10] 周小郁,黄光亮,叶洁仪,等. 三维超声造影融合成像评估肝癌射频消融安全边界的价值[J].中华超声影像学杂志,2019,28(2):103-106.
[11] Zhou J,Wang H,Zhang H,et al.VEGFR2-targeted threedimensional ultrasound imaging can predict responses to antiangiogenic therapy in preclinical models of colon cancer [J].Cancer Res,2016,76(14):4081-4089.
[12] 王双龙,于 美,吕 镔,等. 超声造影定量评估兔肝缺血再灌注损伤动态变化的实验研究[J].中华超声影像学杂志,2018,27(8):725-729.
[13] 吴 明,张欣玉,石 锋,等. 超声造影联合CT 检查对甲状腺良恶性结节的鉴别诊断研究[J]. 陕西医学杂志,2020,49(3):333-336.
[14] Pitre-Champagnat S,Leguerney I,Bosq J,et al.Dynamic contrastenhanced ultrasound parametric maps to evaluate intratumoral vascularization[J].Invest Radiol,2015,50(4):212-217.
[15] Zhao RN,Zhang B,Yang X,et al. Logistic regression analysis of contrast-enhanced ultrasound and conventional ultrasound characteristics of sub-centimeter thyroid nodules[J]. Ultrasound Med Biol,2015,41(12):3102-3108.

相似文献/References:

[1]赵立群,张祥林.CT能谱成像在甲状腺结节良恶性鉴别诊断中的应用价值[J].陕西医学杂志,2019,(5):614.
　ZHAO Liqun,ZHANG Xianglin..CT energy spectrum imaging in thyroid nodules detection and differential diagnosis of benign and malignant value[J].,2019,(5):614.
[2]沈冬花,李 蓉,周玲莉,等.实时剪切波弹性成像超声检查在甲状腺良恶性结节鉴别诊断中的应用[J].陕西医学杂志,2021,50(8):999.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.024]
　SHEN Donghua,LI Rong,ZHOU Lingli,et al.Application of real-time shear wave elastography in differential diagnosis of benign and malignant thyroid nodules[J].,2021,50(5):999.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.024]
[3]何升林,苏 亚,赵 博,等.血清微RNA-181b、促甲状腺激素在甲状腺结节患者体内表达状态及意义[J].陕西医学杂志,2024,(10):1412.[doi:DOI:10.3969/j.issn.1000-7377.2024.10.025]

备注/Memo

备注/Memo:
*山东省济宁市科技助推新旧动能转换计划项目(2017SMNS011)
更新日期/Last Update: 2020-07-28