[1]沈斯瑶,张静雯,邱红霞,等.氧化应激因子、甲状腺激素和血尿酸水平与痛风病情相关性研究*[J].陕西医学杂志,2020,49(5):588-591.
　SHEN Siyao,ZHANG Jingwen,QIU Hongxia,et al.Relationship between oxidative stress,thyroid hormone,blood uric acid and gout[J].,2020,49(5):588-591.
点击复制

氧化应激因子、甲状腺激素和血尿酸水平与痛风病情相关性研究*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年5期
页码:
588-591
栏目:
临床研究
出版日期:
2020-05-05

文章信息/Info

Title:
Relationship between oxidative stress,thyroid hormone,blood uric acid and gout
文章编号:
DOI:10.3969/j.issn.10007377.2020.05.021
作者:
沈斯瑶; 张静雯; 邱红霞; 邵锦华△
西安市第五医院(西安710082)
Author(s):
SHEN Siyao; ZHANG Jingwen; QIU Hongxia; et al.
Xi'an No.5 Hospital( Xi'an 710082)
关键词:
痛风;  血尿酸;  氧化应激;  晚期氧化蛋白产物;  骨破坏;  相关性
Keywords:
Gout;  Blood uric acid;  Oxidative stress;  Advanced oxidation protein product;  Bone destruction;  Correlation
分类号:
R589.7
文献标志码:
A
摘要:
目的:分析氧化应激因子、甲状腺激素和血尿酸水平与痛风患者病情的关系,探讨痛风的发病机制。方法:收集72例痛风患者的临床资料、实验室指标和影像学资料等,并收集与其年龄匹配的30例健康人为正常对照组。对比两组血尿酸(UA)、晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)水平和C-反应蛋白(CRP)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平。分析痛风中亚临床甲状腺功能减退症发生比例,比较两组氧化应激因子AOPP和SOD水平及UA、CRP水平的情况,比较单纯痛风组(n=36)与痛风合并骨破坏组(n=36)患者的AOPP、SOD水平及UA、CRP指标变化,并分析痛风患者AOPP与SOD、UA、CRP、TSH及病程间的相关性。结果:与正常对照组相比,痛风患者合并亚临床甲状腺功能减退症的发生率显著升高,差异有统计学意义(P<0.05); 与正常对照组对比,痛风组SOD显著降低,UA、CRP及AOPP显著升高,差异有统计学意义(P<0.05); 与单纯痛风组对比,痛风合并骨破坏组AOPP水平、CRP显著升高,SOD水平显著降低,差异有统计学意义(P<0.05),UA指标差异无统计学意义(P>0.05)。经Person相关性分析显示,AOPP与SOD呈显著负相关(P<0.05),与CRP、UA、TSH及病程均呈显著正相关(P<0.05)。结论:痛风患者伴亚临床甲状腺功能减退症发病率高于正常人,氧化应激参与了痛风疾病的进展,氧化应激反应与痛风患者的病程、CRP及痛风合并骨破坏存在显著相关性。
Abstract:
Objective:To analyze the relationship between oxidative stress,thyroid hormone,blood uric acid and gout,and to explore the pathogenesis of gout. Methods:The clinical data,laboratory indexes and imaging data of 72 gout patients(gout group)were collected,and 30 healthy people matched with age were selected as normal control group. The levels of serum uric acid(UA),advanced oxidation protein product(AOPP),superoxide dismutase(SOD),C- reactive protein(CRP),thyroid stimulating hormone(TSH),free triiodothyronine(FT3)and free thyroxine(FT4)were compared between the two groups. The incidence rate of subclinical hypothyroidism in gout group was analyzed. The levels of AOPP,SOD,UA and CRP were compared between the two groups. Between the simple gout group(n=36)and gout combined with bone destruction group(n=36),the levels of AOPP,SOD,UA and CRP were compared. The correlation between AOPP and SOD,UA,CRP,TSH and course of disease was analyzed. Results:Compared with the normal control group,the incidence of subclinical hypothyroidism in gout group was significantly increased,with statistically significant difference(P<0.05). Compared with the normal control group,SOD in gout group was decreased significantly,UA,CRP and AOPP were increased significantly,the difference was statistically significant(P<0.05). Compared with the simple gout group,the levels of AOPP and CRP in the gout combined with bone destruction group were significantly increased,the level of SOD was significantly decreased,the difference was statistically significant(P< 0.05),but UA index had no significant difference. Person correlation analysis showed that AOPP was significantly negatively correlated with SOD(P<0.05),and significantly positively correlated with CRP,UA,TSH and course of disease(P<0.05). Conclusion:The incidence rate of sub-clinical hypothyroidism in gout patients is higher than that in normal people. Oxidative stress is involved in the development of gout. Oxidative stress reaction is significantly correlated with the course of gout patients,CRP and gout complicated with bone destruction.

参考文献/References:

[1] 谢招虎,解 静,李兆福,等.痛风性肾病中西医治疗研究进展[J].中华中医药学刊,2019,37(12):2937-2940.
[2] 郭德凯,朱江帆.肥胖症、高尿酸血症和代谢手术相关性的研究进展[J].中华肥胖与代谢病电子杂志,2017,3(1):46-48.
[3] 中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组.甲状腺疾病诊治指南-甲 状 腺 功 能 减 退症[J].中华内科杂志,2007,46( 11):967-971.
[4] 黄金重,林红坤,滕鳪兰,等.痛风患者脂代谢、甲状腺激素及炎症因子水平的变化研究[J].广州医科大学学报,2017,45(4):62-65.
[5] 黄迎峰,蔡绍明.中医内外疗法对急性痛风性关节炎血尿酸水平及炎症因子的影响[J].湖北中医药大学学报,2019,21(6):30-33.
[6] 张静雯,吕艳艳,刘 洋,等.痹症1号对急性痛风性关节炎患者血清炎性因子水平变化的研究[J].陕西中医,2019,40(10):1411-1414.
[7] 张永健,朱立春.方剂联合离子导入在高尿酸、痛风患者中的应用及对TNF-α、IL-1和IL-6水平影响研究[J].陕西中医,2018,39(3):358-360.
[8] 张徐明,姬森国,刘 群,等.非布司他对急性痛风性关节炎患者氧化应激的影响[J].上海医药,2015,36(21):28-31.
[9] 谢克恭,黄 可,石 宇,等.桃红四物汤对急性痛风性关节炎患者外周血炎症因子、氧化应激的表达及生活质量的影响[J].辽宁中医杂志,2019,46(12):2602-2605.
[10] 任广伟,李明明,杨洪娟,等.非布司他对维持性血液透析伴高尿酸血症患者血管内皮功能、氧化应激反应的影响及安全性评价[J].河北医药,2018,40(15):2251-2255.
[11] Wilson C. Bone:oxidative stress and osteoporosis[J]. Nat Rev Endocrinol,2014,10(1):3.
[12] 贺钰梅,韩秀平,汪丽丽,等.痛风性关节炎患者血清Dickkopf-1含量与骨破坏、炎症及氧化反应的相关性研究[J].海南医学院学报,2017,23(17):2357-2360.
[13] 王 翌. 甲状腺功能正常的老年2型糖尿病患者甲状腺激素与骨密度的关系[D].延安:延安大学,2019.
[14] 张桂玲,王 宁,栾 芳,等.高尿酸血症与初诊2型糖尿病患者hs-CRP和心率变异性的关系及干预研究[J].中国急救复苏与灾害医学杂志,2017,12(6):537-540.
[15] 郝晓云. 太原市居民亚临床甲状腺功能减退症与骨代谢的相关性研究[D].太原:山西医科大学,2018.
[16] 朱于青,胡芳志,张艳芳,等.亚临床甲状腺功能减退症患者骨代谢特点研究[J].济宁医学院学报,2019,42(5):350-355

相似文献/References:

[1]辛则霏,张晓妍.不同性别2型糖尿病患者血尿酸与骨代谢标志物关系研究[J].陕西医学杂志,2022,51(6):725.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.020]
　XIN Zefei,ZHANG Xiaoyan.Relationship between serum uric acid and bone metabolism markers in different gender patients with type 2 diabetes mellitus[J].,2022,51(5):725.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.020]
[2]李倩倩,于 华,吴咏静,等.皮质下缺血性脑梗死患者血尿酸水平增高与认知功能损害的关系研究[J].陕西医学杂志,2023,52(7):838.[doi:DOI:10.3969/j.issn.1000-7377.2023.07.014]

备注/Memo

备注/Memo:
*陕西省中医药管理局科研项目(2019-ZZ-LC023)；西安市科技计划项目(J201902041)
更新日期/Last Update: 2020-07-28