[1]董 昕,杨朋康△.单硝酸异山梨酯联合维拉帕米对冠心病稳定型心绞痛患者血脂水平及血清同型半胱氨酸、高敏C反应蛋白的影响*[J].陕西医学杂志,2020,49(4):485-488.
　DONG Xin,YANG Pengkang..Effect of isosorbide mononitrate combined with verapamil on blood lipids levels and serum HCY and hs-CRP in patients with stable angina pectoris[J].,2020,49(4):485-488.
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单硝酸异山梨酯联合维拉帕米对冠心病稳定型心绞痛患者血脂水平及血清同型半胱氨酸、高敏C反应蛋白的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年4期
页码:
485-488
栏目:
药物与临床
出版日期:
2020-04-05

文章信息/Info

Title:
Effect of isosorbide mononitrate combined with verapamil on blood lipids levels and serum HCY and hs-CRP in patients with stable angina pectoris
文章编号:
DOI:10.3969/j.issn.10007377.2020.04.025
作者:
董 昕1 ; 杨朋康2△
1.西安市第四医院心内科(西安 710004); 2.西安市第一医院心内科(西安 710002)
Author(s):
DONG Xin; YANG Pengkang.
Department of Cardiology,Xi'an Fourth Hospital(Xi'an 710004)
关键词:
单硝酸异山梨酯;  维拉帕米;  冠心病;  稳定型心绞痛;  血脂;  同型半胱氨酸;  高敏C反应蛋白
Keywords:
Isosorbide mononitrate;  Verapamil;  Coronary heart disease;  Stable angina pectoris;  Blood lipids;  HCY;  hs-CRP
分类号:
R541.4
文献标志码:
A
摘要:
目的:研究单硝酸异山梨酯联合维拉帕米对冠心病稳定型心绞痛患者血脂水平及血清同型半胱氨酸(HCY)、高敏C反应蛋白(hs-CRP)的影响。方法:将86例冠心病稳定型心绞痛患者随机均分为研究组(单硝酸异山梨酯联合维拉帕米治疗)和对照组(维拉帕米治疗)各43例。比较两组治疗效果,记录两组治疗4周后心绞痛发作情况(心绞痛发作频率、心绞痛发作时间、心绞痛积分),记录两组治疗前及治疗4周后血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、炎性因子[hs-CRP、白细胞介素-6(IL-6)]、血清疾病相关因子[HCY、脂联素(APN)、胸腺基质淋巴细胞生成素(TSLP)]水平。结果:治疗4周后,研究组总有效率明显大于对照组(P<0.05); 研究组心绞痛发作频率、心绞痛发作时间、心绞痛积分均明显小于对照组,两组比较差异有统计学意义(P<0.05)。治疗4周后,两组患者TC、TG、LDL-C、炎性因子(hs-CRP、IL-6)、HCY、TSLP水平均较治疗前显著下降,研究组明显低于对照组; 两组患者HDL-C、APN水平均较治疗前显著上升,研究组明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论:单硝酸异山梨酯联合维拉帕米对冠心病稳定型心绞痛患者具有良好疗效,能够降低患者血脂、HCY、hs-CRP水平,缓解心绞痛症状。
Abstract:
Objective:To study the effect of isosorbide mononitrate combined with verapamil on blood lipids levels and serum homocysteine(HCY)and high-sensitivity C-reactive protein(hs-CRP)in patients with stable angina pectoris. Methods:Eighty-six patients with stable angina pectoris were randomly divided into study group(isosorbide mononitrate combined with verapamil treatment)and control group(verapamil treatment)with 43 cases in each group. The treatment effectiveness were compared between the two groups. The angina pectoris attacks(frequency of angina pectoris,duration of angina pectoris,score of angina pectoris)in the two groups after 4 weeks of treatment were recorded. The levels of blood lipids [total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)],inflammatory factors [hs-CRP,interleukin-6(IL-6)] and serum disease-related factors [HCY,adiponectin(APN),thymic stromal lymphopoietin(TSLP)] in the two groups before treatment and after 4 weeks of treatment were recorded. Results:After 4 weeks of treatment,the total effective rate in study group was significantly higher than that in control group(P<0.05). The frequency of angina pectoris,duration of angina pectoris and score of angina pectoris in study group were significantly lower than those in control group(P<0.05). After 4 weeks of treatment,the levels of TC,TG,LDL-C,inflammatory factors(hs-CRP,IL-6),HCY and TSLP in two groups were significantly decreased compared with those before treatment,and the levels in study group were significantly lower than those in control group(P<0.05); the levels of HDL-C and APN in two groups were significantly increased compared with those before treatment,and the levels in study group were significantly higher than those in control group(P<0.05). Conclusion:Isosorbide mononitrate combined with verapamil has a good efficacy on patients with stable angina pectoris. It can reduce the levels of blood lipids,HCY and hs-CRP,and alleviate the symptoms of angina pectoris.

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备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2017SF-039)
更新日期/Last Update: 2020-04-13