[1]刘 静.红细胞分布宽度联合降钙素原检测对急性胰腺炎严重程度及预后评估价值分析[J].陕西医学杂志,2020,49(4):470-473,497.
　LIU Jing..Value of Red cell distribution width combined with procalcitonin in evaluating the severity and prognosis of acute pancreatitis[J].,2020,49(4):470-473,497.
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红细胞分布宽度联合降钙素原检测对急性胰腺炎严重程度及预后评估价值分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年4期
页码:
470-473,497
栏目:
临床研究
出版日期:
2020-04-05

文章信息/Info

Title:
Value of Red cell distribution width combined with procalcitonin in evaluating the severity and prognosis of acute pancreatitis
文章编号:
DOI:10.3969/j.issn.10007377.2020.04.021
作者:
刘 静
四川省江油市第二人民医院(江油 621701)
Author(s):
LIU Jing.
Second People's Hospital of Jiangyou City,Sichuan Province(Jiangyou 621701)
关键词:
急性胰腺炎;  红细胞分布宽度;  降钙素原;  超敏C反应蛋白;  血清肿瘤坏死因子-α;  预后
Keywords:
Acute pancreatitis;  Red cell distribution width;  Procalcitonin;  High-sensitivity C-reactive protein;  Serum tumor necrosis factor-α;  Prognosis
分类号:
R657.51
文献标志码:
A
摘要:
目的:分析联合检测红细胞分布宽度(RDW)和降钙素原(PCT)对急性胰腺炎(AP)严重程度及预后的评估效果,为临床治疗提供参考。方法:随机选取AP患者118例,将其分为轻症急性胰腺炎(MAP)组(n=59)和AP合并严重感染(SAP)组(n=59),比较两组患者入院24 h后的临床指标。结果:SAP组PCT、RDW、超敏C反应蛋白(hs-CRP)、血清肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)以及急性生理及慢性健康(APACHE-Ⅱ)评分分别为(3.18±0.62)μg/L,(18.27±4.32)%,(5.62±5.15)mg/L,(102.90±46.31)mg/L,(5.49±0.53)mg/L,(17.29±2.67)分,均明显高于MAP组,MAP组分别为(0.59±0.14)μg/L,(14.12±1.80)%,(16.32±2.21)mg/L,(42.93±18.46)mg/L,(2.25±0.13)mg/L,(8.18±1.23)分,差异有统计学意义(P<0.05); SAP组的病死率为11.9%; 死亡患者上述指标均明显高于存活患者,差异有统计学意义(P<0.05); Pearson、Spearman相关性分析结果显示,上述指标与APACHE-Ⅱ评分均存在显著正相关性; ROC曲线分析得出APACHE-Ⅱ评分的曲线下面积为0.859(95%CI:0.740～0.976,P=0.001); PCT的曲线下面积为0.825(95%CI:0.687～0.964,P=0.004); RDW的曲线下面积为0.847(95%CI:0.746～0.945,P=0.001); PCT+RDW的曲线下面积为0.913(95%CI:0.830～0.993,P=0.001)。结论:联合检测RDW和PCT对于AP严重程度和预后判断具有重要价值。
Abstract:
Objective:To analyze the evaluation effect of combined detection of Red cell distribution width(RDW)and procalcitonin(PCT)on the severity and prognosis of acute pancreatitis(AP),so as to provide reference for clinical treatment. Methods:Totally 118 patients with AP were randomly divided into mild acute pancreatitis(MAP)group(n=59)and severe infection(SAP)group(n=59). The clinical indexes of two groups 24 hours after admission were compared. Results:The values of PCT,RDW,hs-CRP,TNF-α,IL-8 and APACHE-Ⅱ in the SAP group were respectively(3.18±0.62)μg/L,(18.27±4.32)%,(5.62±5.15)mg/L,(102.90±46.31)mg/L,(5.49±0.53)mg/L,(17.29±2.67)points,while those in the MAP group were respectively(0.59±0.14)μg/L,(14.12±1.80)%,(16.32±2.21)mg/L,(42.93±18.46)mg/L,(2.25±0.13)mg/L and(8.18 ± 1.23)points. There was statistically significant difference between two groups(P<0.05).The mortality of SAP group was 11.9%. The above indicators of dead patients were significantly higher than those of surviving patients,and the difference was statistically significant(P<0.05). Pearson and Spearman correlation analysis showed thatthe above indicators and Apache-Ⅱ scores have significant positive correlation. ROC curve analysis showed that the area under the curve of the APACHE-Ⅱ score was 0.859(95%CI 0.740 to 0.976,P=0.001),the area under the curve of PCT was 0.825(95%CI 0.687 to 0.964,P=0.004),the area under the curve of RDW was 0.847(95%CI 0.746 to 0.945,P=0.001),the area under the curve of PCT plus RDW was 0.913(95%CI 0.830 to 0.993,P=0.001). Conclusion:The combined detection of RDW and PCT is of great value for the severity and prognosis of AP.

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更新日期/Last Update: 2020-04-13