[1]陈 芳,杜锦辉△.机械通气辅以纳洛酮治疗慢性阻塞性肺疾病并呼吸衰竭疗效研究[J].陕西医学杂志,2020,49(4):466-469.
　CHEN Fang,DU Jinhui..Effect of mechanical ventilation combined with naloxone on operation related indexes and therapeutic effect in COPD patients with respiratory failure[J].,2020,49(4):466-469.
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机械通气辅以纳洛酮治疗慢性阻塞性肺疾病并呼吸衰竭疗效研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年4期
页码:
466-469
栏目:
临床研究
出版日期:
2020-04-05

文章信息/Info

Title:
Effect of mechanical ventilation combined with naloxone on operation related indexes and therapeutic effect in COPD patients with respiratory failure
文章编号:
DOI:10.3969/j.issn.10007377.2020.04.020
作者:
陈 芳; 杜锦辉△
陕西省宝鸡市中医医院重症医学科(宝鸡721001)
Author(s):
CHEN Fang; DU Jinhui.
Department of Critical Medicine,Baoji Hospital of Traditional Chinese Medicine(Baoji 721001)
关键词:
机械通气;  纳洛酮;  慢性阻塞性肺疾病;  呼吸衰竭;  血气指标
Keywords:
Mechanical ventilation;  Naloxone;  Chronic obstructive pulmonary disease;  Respiratory failure;  Blood gas indicators
分类号:
R563.8
文献标志码:
A
摘要:
目的:探究机械通气辅以纳洛酮对慢性阻塞性肺疾病(COPD)并呼衰患者手术相关指标与疗效的影响。方法:选取90例COPD并呼衰患者进行研究,按照奇偶数法分组(每组45例),对照组采用机械通气治疗,观察组采用机械通气辅以纳洛酮治疗,对比两组临床疗效。结果:治疗后12、48 h,观察组的动脉血氧分压(PaO2)、pH值等指标高于对照组,动脉血二氧化碳分压(PaCO2)低于对照组(P<0.05); 观察组的呼吸困难量表评分低于对照组,机械通气时间、ICU病房监护时间、住院时间均短于对照组(P<0.05); 治疗后,观察组肺动脉收缩压(PASP)、呼吸频率(RR)、心率(HR)等指标均低于对照组(P<0.05); 治疗后3个月,观察组患者的病死率及再插管率均低于对照组(P<0.05)。结论:在COPD并呼衰患者中采用机械通气辅以纳洛酮治疗,可改善其血气分析指标、呼吸功能,缩短机械通气、ICU病房监护、住院等时间,稳定生命体征,降低病死率及再插管率。
Abstract:
Objective:To explore the effect of mechanical ventilation combined with naloxone on operation related indexes and curative effect in patients with chronic obstructive pulmonary disease(COPD)and respiratory failure. Methods:A total of 90 COPD patients with respiratory failure were selected and divided into observation group and control group according to the even-odd method,45 cases in each group. The control group was treated with mechanical ventilation,and the observation group was treated with mechanical ventilation and naloxone. The clinical effects of the two groups were compared. Results:12 hours and 48 hours after treatment,the arterial blood oxygen partial pressure(PaO2)and pH value of observation group were higher than those of control group,but the arterial blood carbon dioxide partial pressure(PaCO2)was lower than that of control group(P<0.05). The dyspnea score of observation group was lower than that of control group,and the time of mechanical ventilation,ICU ward monitoring and hospitalization were shorter than those of control group(P<0.05). After treatment,the pulmonary systolic blood pressure(PASP),respiratory rate(RR),heart rate(HR)and other indicators in observation group were lower than those in control group(P<0.05). 3 months after treatment,the rate of mortality and reintubation in observation group were lower than those in control group(P<0.05). Conclusion:Mechanical ventilation combined with naloxone treatment in COPD patients with respiratory failure can improve blood gas analysis indicators and respiratory function,shorten the time of mechanical ventilation,ICU ward monitoring and hospitalization,stabilize vital signs,reduce mortality and reintubation rate.

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更新日期/Last Update: 2020-04-13