[1]黄亮星,贺东红△.脑出血患者神经内分泌因子表达水平与脑出血量及认知功能相关性研究*[J].陕西医学杂志,2020,49(4):439-441，509.
　HUANG Liangxing,HE Donghong..Correlation between expression levels of neuroendocrine factors and the amount of hemorrhage and cognitive function in patients with cerebral hemorrhage[J].,2020,49(4):439-441，509.
点击复制

脑出血患者神经内分泌因子表达水平与脑出血量及认知功能相关性研究*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年4期
页码:
439-441，509
栏目:
临床研究
出版日期:
2020-04-05

文章信息/Info

Title:
Correlation between expression levels of neuroendocrine factors and the amount of hemorrhage and cognitive function in patients with cerebral hemorrhage
文章编号:
DOI:10.3969/j.issn.10007377.2020.04.013
作者:
黄亮星; 贺东红△
陕西省榆林市第二医院神经内科(榆林719000)
Author(s):
HUANG Liangxing; HE Donghong.
Department of Neurology,Yulin No.2 Hospital,Shaanxi Province(Yulin 719000)
关键词:
脑出血;  神经元特异性烯醇化酶;  胰岛素生长因子-Ⅰ;  Tau蛋白;  视锥蛋白样蛋白-1;  脑出血量;  认知功能
Keywords:
Cerebral hemorrhage;  Neuron specific enolase;  Insulin growth factor-Ⅰ;  Tau protein;  Cone protein-like protein-1;  Volume of cerebral hemorrhage;  Cognitive function
分类号:
R743
文献标志码:
A
摘要:
目的:探究脑出血(CH)患者神经内分泌因子表达水平与脑出血量及认知功能间相关性。方法:选择125例CH患者(研究组)和同期体检的50例健康志愿者(对照组)为研究对象。测定两组血清神经元特异性烯醇化酶(NSE)、胰岛素生长因子-Ⅰ(IGF-Ⅰ)、Tau蛋白、视锥蛋白样蛋白-1(VILIP-1)水平,计算研究组脑出血量,蒙特利尔认知评估量表(MoCA)评估其治疗后认知功能,并依据脑出血量和认知功能评估结果对研究组进行分组。对比各组受试者血清神经内分泌因子表达水平变化情况。结果:与对照组比,研究组NSE、Tau蛋白、VILIP-1水平均明显升高(P<0.01)。不同出血量患者血清NSE、IGF-Ⅰ、Tau蛋白、VILIP-1水平间比较差异均具有统计学意义(P<0.01),血清NSE、Tau蛋白、VILIP-1与脑出血量呈现显著正相关,IGF-Ⅰ与脑出血量呈现显著负相关(P<0.01); 治疗后CI组与NCI组血清NSE、IGF-Ⅰ、Tau蛋白、VILIP-1水平间比较差异具有统计学意义(P<0.01),患者血清NSE、Tau蛋白、VILIP-1水平与MoCA评分呈现显著负相关,IGF-Ⅰ水平与MoCA评分呈现显著正相关(P<0.01)。结论:CH患者血清NSE、Tau蛋白、VILIP-1水平与脑出血量呈正相关,与治疗后MoCA评分呈负相关,IGF-Ⅰ水平与脑出血量呈负相关,与MoCA评分呈正相关。
Abstract:
Objective:To investigate the correlation between the expression levels of neuroendocrine factors and the amount of cerebral hemorrhage and cognitive function in patients with cerebral hemorrhage(CH). Methods:125 CH patients were selected as study group,and 50 healthy volunteers for physical examination in the same period were selected as control group. Serum levels of neuron specific enolase(NSE),insulin growth factor-I(IGF-Ⅰ),Tau protein and cone protein-like protein-1(VILIP-1)were measured. The cerebral hemorrhage volume of the study group was calculated,and the Montreal Cognitive Assessment Scale(MoCA)was used to evaluate post-treatment cognitive function,and the study group was grouped according to the cerebral hemorrhage volume and cognitive function evaluation results. The changes of serum neuroendocrine factors expression levels in each group were compared. Results:Compared with the control group,the NSE,Tau protein and VILIP-1 levels in the study group were significantly increased(P<0.01). There were significant differences in serum NSE,IGF-Ⅰ,Tau protein and VILIP-1 levels between patients with different bleeding volume(P<0.01). The serum NSE,Tau protein and VILIP-1 were significantly positively correlated with the amount of cerebral hemorrhage,and IGF -I showed a significant negative correlation with the amount of cerebral hemorrhage(P<0.01). After treatment,there were significant differences in serum NSE,IGF-Ⅰ,Tau protein and VILIP-1 levels between the CI group and the NCI group(P<0.01),the levels of serum NSE,Tau protein and VILIP-1 were significantly negatively correlated with MoCA scores,and IGF-Ⅰ level weresignificantly positively correlated with MoCA scores(P<0.01). Conclusion:The levels of serum NSE,Tau protein and VILIP-1 in CH patients are positively correlated with the amount of cerebral hemorrhage,and negatively correlated with MoCA scores after treatment. IGF-Ⅰ level is negatively correlated with the amount of cerebral hemorrhage and positively correlated with MoCA scores.

参考文献/References:

[1] Kostereva NV,Yong W,Fletcher DR,et al. IGF-1 and chondroitinase ABC augment nerve regeneration after vascularized composite limb allotransplantation[J]. Plos One,2016,11(6):1-17.
[2] 闫建华,周 扬,冀瑞俊. 脑梗死患者血清中IGF-1、IL-2及ICAM-1水平与血管狭窄及神经功能的关系[J]. 解放军预防医学杂志,2019,37(4):73-74.
[3] Zha GB,Shen M,Gu XI,et al. Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration[J]. Neural Regeneration Research,2016,11(9):1506-1511.
[4] Jensen CS,Portelius E,Peter H,et al. Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease[J]. Alzheimers & Dementia Translational Research & Clinical Interventions,2017,3(2):284-290.
[5] 王新德. 各类脑血管疾病诊断要点[J]. 中华神经科杂志,1996,3(6):379-380.
[6] 宋 璞,汪 亮. 通瘀汤对脑出血恢复期患者神经功能缺损及康复效果疗效研究[J]. 陕西中医,2017,38(1):24-26.
[7] 袁 玲,王 军. 神经元特异性烯醇化酶及血清γ-GT在诊断新生儿胆红素脑病中的价值[J]. 河北医学,2019,25(6):931-935.
[8] 李 旗. NSE、S100β与老年高血压性脑出血患者认知障碍的相关性研究[J]. 陕西医学杂志,2015,44(8):1030-1031.
[9] 王 莉,马耀红,刘 华,等. IGF-Ⅰ和GH在缺氧缺血性脑病新生儿血清中的表达及其临床意义[J]. 现代生物医学进展,2015,15(27):84-86,90.
[10] 褚忠海,王文静,韩丽珠. 皮质下缺血性脑血管病患者血清sICAM-1、IGF-1水平与认知损害的关系[J]. 安徽医科大学学报,2016,51(2):268-271.
[11] 唐艳林,黄 晶,王 锋,等. 血清tau蛋白、S100蛋白的表达与早产儿神经损伤相关性分析[J]. 中国计划生育学杂志,2019,27(8):1065-1068.
[12] 郝璞珩,李 娜,金 林. 血清 Tau 蛋白水平与脑出血患者早期预后的相关性分析[J].临床神经外科杂志,2014,31(6):453-455.
[13] 刘晓丽,张秀芝,蔡 军,等. VILIP-1在早期缺血性脑卒中的临床诊断价值[J]. 中国卫生检验杂志,2014,24(15):2135-2137.
[14] 王茂松,王 宏,李 萌. 卒中后认知功能障碍患者血清VILIP-1水平变化及其临床意义[J]. 实用临床医学(江西),2016,17(6):1-4.
[15] 马建华,李 鑫,戴宜武. 脐血源神经干细胞在SDF-1/CXCR4趋化下对脑出血大鼠神经损伤恢复的作用[J]. 中华神经医学杂志,2019,18(4):344-350.

相似文献/References:

[1]杨瑞林,李博.微创穿刺血肿清除术治疗高血压脑出血65例[J].陕西医学杂志,2016,(10):1371.
[2]杨生琴.立体定向软通道颅内血肿清除术治疗高血压性脑出血患者近期神经功能恢复临床研究[J].陕西医学杂志,2019,(4):482.
　YANG Shengqin..Clinical research of neurological function in patients with hypertensive intracerebral hemorrhage by stereotactic soft channel intracranial hematoma evacuation[J].,2019,(4):482.
[3]赵志靖,第五飞虎△,邓毅恒,等.醒脑静对大鼠脑出血病灶周围星形胶质细胞表达水通道蛋白4的影响研究*[J].陕西医学杂志,2019,(10):1251.
　ZHAO Zhijing,DIWU Feihu,DENG Yiheng,et al.Effect of Xingnaojing on the expression of AQP4 in 〖JZ〗peripheral astrocytes of rats after intracerebral hemorrhage[J].,2019,(4):1251.
[4]刘鹏程,罗有才,纪文军,等.立体定向-改良软通道微创介入颅内血肿清除术对高血压脑出血患者血清NSE、S100B、炎症因子水平及预后的影响[J].陕西医学杂志,2020,49(3):321.
　LIU Pengcheng,LUO Youcai,JI Wenjun,et al.Effects of stereoscopic orientation-modified soft-channel minimally invasive intervention intracranial hematoma evacuation on serum NSE,S100B,inflammatory factor levels and prognosis in patients with hypertensive intracerebral hemorrhage[J].,2020,49(4):321.
[5]栾百婷,罗 涛,程洪瑜,等.脑出血患者穿刺引流术后尿激酶应用剂量和时间研究*[J].陕西医学杂志,2020,49(11):1399.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.008]
　LUAN Baiting,LUO Tao,CHENG Hongyu,et al.Study on the dose and timing of the application of urokinase after puncture drainage in patients with intracerebral hemorrhage[J].,2020,49(4):1399.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.008]
[6]李晨红,黄传俊,姜晨黎,等.甘露醇联合肠内营养治疗脑出血疗效及对患者免疫功能的影响[J].陕西医学杂志,2021,50(2):212.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.022]
　LI Chenhong,HUANG Chuanjun,JIANG Chenli,et al.Efficacy of mannitol combined with enteral nutrition in treatment of cerebral hemorrhage and its influence on patients' immune function[J].,2021,50(4):212.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.022]
[7]谢 军,刘静静,曾海燕,等.3D辅助下神经内镜结合吡拉西坦对脑出血患者血清因子和神经功能影响的临床研究[J].陕西医学杂志,2021,50(4):464.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.021]
　XIE Jun,LIU Jingjing,ZENG Haiyan,et al.Effect of 3D-assisted neuroendoscopy combined with piracetam on serum factors and neurological function in patients with cerebral hemorrhage[J].,2021,50(4):464.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.021]
[8]张 鹏.缺氧缺血性脑病新生儿血清髓鞘碱性蛋白、神经元特异性烯醇化酶水平与病情严重程度相关性分析及预后评估价值[J].陕西医学杂志,2021,50(6):720.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.020]
[9]阮长龙,廖应英,孙泽群.胃肠胰神经内分泌肿瘤早期诊断血清标志物研究进展[J].陕西医学杂志,2021,50(12):1602.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.034]
　RUAN Changlong,LIAO Yingying,SUN Zequn.Research progress on serum markers for early diagnosis of gastroenteropancreatic neuroendocrine neoplasms[J].,2021,50(4):1602.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.034]
[10]黄建成,郭建峰,吴水清,等.胃泌素释放肽前体、神经元特异性烯醇化酶、细胞角蛋白19片段、癌胚抗原及胃泌素释放肽前体及神经元特异性烯醇化酶联合检测对小细胞肺癌的诊断效能[J].陕西医学杂志,2022,51(10):1301.[doi:DOI:10.3969/j.issn.1000-7377.2022.10.031]
[11]段 鹏,杨明金△.脑出血患者神经元特异性烯醇化酶检测及临床意义[J].陕西医学杂志,2020,49(2):234.
　DUAN Peng,YANG Mingjin..Detection and clinical significance of neuron specific enolase in patients with cerebral hemorrhage[J].,2020,49(4):234.

备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2018CM7110)
更新日期/Last Update: 2020-04-13