[1]彭 娜,卢美君,康马飞△,等.白藜芦醇抑制重组人白细胞介素11促进肺腺癌转移灶形成实验研究*[J].陕西医学杂志,2020,49(4):401-404.
　PENG Na,LU Meijun,KANG Mafei,et al.Experimental study on resveratrol inhibited the formation of metastatic lesions of lung adenocarcinoma promoted by recombinant human interleukin 11[J].,2020,49(4):401-404.
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白藜芦醇抑制重组人白细胞介素11促进肺腺癌转移灶形成实验研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年4期
页码:
401-404
栏目:
基础研究
出版日期:
2020-04-05

文章信息/Info

Title:
Experimental study on resveratrol inhibited the formation of metastatic lesions of lung adenocarcinoma promoted by recombinant human interleukin 11
文章编号:
DOI:10.3969/j.issn.10007377.2020.04.004
作者:
彭 娜; 卢美君; 康马飞△; 刘秀丽; 李碧慧; 董翠梅
桂林医学院附属医院肿瘤内科(桂林541001)
Author(s):
PENG Na; LU Meijun; KANG Mafei; et al.
Department of Medical Oncology,Affiliated Hospital of Guilin Medical University(Guilin 541001)
关键词:
肺肿瘤;  白藜芦醇;  重组人白细胞介素11;  转移;  动物实验
Keywords:
Lung cancer;  Resveratrol;  Recombinant human interleukin 11(rhIL-11);  Metastasis;  Animal experiment
分类号:
R734.2
文献标志码:
A
摘要:
目的:探讨外源性重组人白细胞介素11(rhIL-11)促进肿瘤转移,而白藜芦醇抑制肺腺癌A549细胞转移灶形成,为进一步研究提供理论依据。方法:经裸鼠尾静脉注入肺腺癌A549细胞,建立肿瘤转移模型,同时使用不同剂量rhIL-11单药或联合白藜芦醇进行干预,比较各组出现转移灶的裸鼠数量和各组转移灶数量的差异。结果:对照组有1只裸鼠出现转移灶,转移率为16.7%(1/6),低剂量rhIL-11组有3只裸鼠出现转移灶,转移率为50.0%(3/6),高剂量rhIL-11组有4只裸鼠出现转移灶,转移率为66.7%(4/6)。 rhIL-11[750 μg/(kg?d)]+白藜芦醇组和rhIL-11 [500 μg/(kg?d)]+白藜芦醇组出现转移灶的裸鼠数少于rhIL-11组[750 μg/(kg?d)]和rhIL-11组[500 μg/(kg?d)](3/12对7/12),比较差异无统计学意义(χ2=2.743,P=0.098)。且转移灶个数也少于rhIL-11组(5个对13个)。结论:rhIL-11可能促进肿瘤转移灶的形成,而白藜芦醇可能有抑制rhIL-11促肿瘤转移灶形成作用。
Abstract:
Objective:To investigate whether exogenous recombinant human interleukin 11(rhIL-11)can promote tumor metastasis,and whether resveratrol can inhibit the formation of metastases of lung adenocarcinoma A549 cells,and provide theoretical basis for further research. Methods:Lung adenocarcinoma A549 cells were injected into the tail vein of nude mice to establish a tumor metastasis model,and different doses of rhIL-11 alone or in combination with resveratrol were used for intervention,and the number of nude mice with metastatic lesions and the number of metastatic lesions in each group were compared. Results:The metastasis rate was 16.7%(1/6)in the control group,50.0%(3/6)in the low-dose rhIL-11 group and 66.7%(4/6)in the high-dose rhIL-11 group. The number of nude mice with metastatic lesions in rhIL-11 + resveratrol groups [rhIL-11 750 μg/(kg·d)+ resveratrol group and rhIL-11 500 μg/(kg·d)+ resveratrol group] was less than that in rhIL-11 groups [rhIL-11 750 μg/(kg·d)group and rhIL-11 500 μg/(kg·d)](3/12 vs.7/12),but the difference was not statistically significant(χ2=2.743,P=0.098). The number of metastatic lesions in rhIL-11 + resveratrol groups was also less than that in rhIL-11 groups(5 vs.13). Conclusion:rhIL-11 may promote the formation of tumor metastasis,while may be inhibited by resveratrol.

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备注/Memo

备注/Memo:
*广西壮族自治区自然科学基金资助面上项目(2016GXNSFBAA380307)
更新日期/Last Update: 2020-04-13