[1]陈玉林,董甲庆△.复方谷氨酰胺颗粒与肠内营养治疗溃疡性结肠炎临床研究[J].陕西医学杂志,2020,49(1):115-117，封3.
　CHEN Yulin,DONG Jiaqing..Clinical study of compound glutamine granules and enteral nutrition in the treatment of ulcerative colitis[J].,2020,49(1):115-117，封3.
点击复制

复方谷氨酰胺颗粒与肠内营养治疗溃疡性结肠炎临床研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年1期
页码:
115-117，封3
栏目:
药物与临床
出版日期:
2020-01-05

文章信息/Info

Title:
Clinical study of compound glutamine granules and enteral nutrition in the treatment of ulcerative colitis
文章编号:
DOI:10.3969/j.issn.10007377.2020.01.032
作者:
陈玉林; 董甲庆△
西安医学院第二附属医院（西安 710038）
Author(s):
CHEN Yulin; DONG Jiaqing.
The Second Affiliated Hospital of Xi’an Medical College (Xi’an 710038)
关键词:
溃疡性结肠炎; 复方谷氨酰胺颗粒; 肠内营养; 肿瘤坏死因子α; 白介素8
Keywords:
Key words Ulcerative colitis; Compound glutamine granules; Enteral nutrition; TNFα; IL8
分类号:
R574.62
文献标志码:
A
摘要:
摘 要 目的：探讨复方谷氨酰胺颗粒与肠内营养治疗溃疡性结肠炎患者的疗效。方法：分层抽样法选取90例溃疡性结肠炎患者。对照组（45例）采用复方谷氨酰胺颗粒治疗，治疗组（45例）采用复方谷氨酰胺颗粒、肠内营养治疗。比较两组治疗效果。结果：治疗后，治疗组肿瘤坏死因子α（TNFα）、白介素8（IL8）水平低于对照组（P＜0.05）；治疗组治疗总有效率（95.56%）高于对照组（80.00%）（P＜0.05）；治疗组血清白蛋白（ALB）、血红蛋白（Hb）高于对照组（P＜0.05）；治疗组不良反应发生率为4.44%，对照组则为6.67%（P＞0.05）。结论：溃疡性结肠炎治疗中联用复方谷氨酰胺颗粒与肠内营养可改善营养状况，减轻炎症反应，提升治疗效果，且不良反应少。
Abstract:
Abstract Objective:To investigate the effect of compound glutamine granules and enteral nutrition in the treatment of ulcerative colitis.Methods: 90 patients with ulcerative colitis were selected by stratified sampling method and divided into study group and control group,with 45 cases in each group.The control group was treated with compound glutamine granules,while the study group was treated with compound glutamine granules and enteral nutrition.The therapeutic efficacy were compared between the two groups.Results: After treatment,the levels of TNFα and IL8 in the study group were lower than those in the control group (P＜005).The total effective rate (9556%) in the study group was higher than that (80.00%) in the control group(P＜005).The levels of ALB and Hb in the study group were higher than those in the control group (P＜005).The incidence of adverse reactions 444% was in the study group and 6.67% in the control group (P＞005).Conclusion: Combined use of compound glutamine granules and enteral nutrition in the treatment of ulcerative colitis can improve the nutritional status,reduce inflammatory response,improve the treatment effect,and have fewer adverse reactions.

参考文献/References:

[1] Vipul J,John WD， McDonald,et al. Ulcerative colitis[M].Evidencebased Gastroenterology and Hepatology，2019:2225.
[2] 赵振营. 溃疡性结肠炎中药组方规律及整合药理学分子机制探索[J]. 中草药,2018,49(13):30423050.
[3] Yao P,Tan F,Gao H. Effects of probiotics on Toll like receptor expression in ulcerative colitis rats induced by 2,4,6 trinitro benzene sulfonic acid[J]. Molecular Medicine Reports,2017:19731980.
[4] 唐美月,陈 威,曹 硕,等. 美沙拉嗪联合复方谷氨酰胺治疗急性放射性肠炎的疗效观察[J]. 中国医师进修杂志,2019,42(2):124126.
[5] 中国中西医结合学会消化系统疾病专业委员会. 溃疡性结肠炎中西医结合诊疗指南(草案)[J]. 中国中西医结合消化杂志,2011,19(1):6165.〖JY〗(下转封3)〖FL)〗
[6] Atta AH,Mouneir SM,Nasr SM. Phytochemical studies and antiulcerative colitis effect of Moringa oleifera seeds and Egyptian propolis methanol extracts in a rat model[J]. Asian Pacific Journal of Tropical Biomedicine,2019,9(3):98108.
[7] Garg M,Philip H,John ND. The effect of vitamin d on intestinal inflammation and faecal microbiota in patients with ulcerative colitis[J]. Journal of Crohn S & Colitis,2018,12(8):362365.
[8] 李 骥,韦明明,费贵军,等. 环孢素A治疗糖皮质激素抵抗的重度溃疡性结肠炎疗效观察[J]. 中华内科杂志,2017,56(4):279283.
[9] 袁 援. 薏苡附子败酱散保留灌肠结合柳氮磺胺吡啶治疗溃疡性结肠炎临床研究[J]. 国际中医中药杂志,2017,39(3):221224.
[10] 张 莉,顾 清,张 璐,等.美沙拉嗪联合嗜热链球菌及复方谷氨酰胺对溃疡性结肠炎患者炎性因子及免疫功能的影响[J].川北医学院学报,2019,34(4):325328.
[11] 卢 浩,谭华俊,冯若扬,等. 谷氨酰胺强化肠内营养治疗重型创伤性脑损伤的Meta分析[J]. 中华创伤杂志,2018,34(10):898.
[12] 刘 博,王玉梅,周少英,等. 强化谷氨酰胺的肠内营养联合微生态制剂对重症急性胰腺炎患者临床预后的影响[J]. 现代中西医结合杂志,2017,26(17):18381840.
[13] 丁 瑜,侯惠如,李英男. 肠内营养患者胃残余量监测的研究进展[J]. 安徽医药,2018,22(2):212214.
[14] 梁 锐,陈改云,王素凡,等. 免疫肠内营养治疗急性应激患者的随机对照研究[J]. 中华急诊医学杂志,2019,28(5):604608.
[15] 王凤纤,缪应雷,张雪芹,等.中重度溃疡性结肠炎患者肠内营养支持治疗的回顾性分析[J].胃肠病学,2019,24(4):235238.

相似文献/References:

[1]李竹林,赵 瑛.高强度间歇性运动联合药物治疗溃疡性结肠炎疗效及对患者细胞因子水平影响研究*[J].陕西医学杂志,2019,(7):909.
　LI Zhulin,ZHAO Ying..Therapeutic effect of high-intensity intermittent exercise combined with drugs on ulcerative colitis and its effect on cytokine levels in patients[J].,2019,(1):909.
[2]安 敏,高振军.美沙拉秦长期治疗对溃疡性结肠炎患者结肠黏膜癌相关基因表达的影响[J].陕西医学杂志,2021,50(4):485.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.027]
[3]付 静,刘小婷,孙 婷,等.陕产七叶一枝花对小鼠溃疡性结肠炎的治疗作用及机制实验研究[J].陕西医学杂志,2024,(9):1161.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.002]
　FU Jing,LIU Xiaoting,SUN Ting,et al.Therapeutic effect and mechanism of Paris polyphylla Sm. from Shaanxi on ulcerative colitis in mice[J].,2024,(1):1161.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.002]
[4]池文婕,靳改玲,王佳敏,等.溃疡性结肠炎患者结肠黏膜组织叉头框转录因子M1、核因子-κΒ mRNA表达与病情严重程度关系研究[J].陕西医学杂志,2024,(9):1264.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.024]
　CHI Wenjie,JIN Gailing,WANG Jiamin,et al.Relationship between expression of FoxM1,NF-κΒ mRNA in colonic mucosal tissue of patients with ulcerative colitis and severity of the disease[J].,2024,(1):1264.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.024]
[5]黄小刚,崔锦珠,覃小华,等.基于细胞焦亡探讨龙血竭治疗溃疡性结肠炎机制研究进展[J].陕西医学杂志,2024,(9):1282.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.028]
　HUANG Xiaogang,CUI Jinzhu,QIN Xiaohua,et al.Research progress on mechanism of dragon's blood in treatment of ulcerative colitis based on pyroptosis[J].,2024,(1):1282.[doi:DOI:10.3969/j.issn.1000-7377.2024.09.028]
[6]袁芸菲,刘清娥,李 森,等.桔梗多糖经血小板衍生生长因子受体/血管内皮生长因子受体途径调控巨噬细胞对溃疡性结肠炎模型小鼠黏膜损伤的改善作用及机制研究[J].陕西医学杂志,2025,54(3):301.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.003]
　YUAN Yunfei,LIU Qing'e,LI Sen,et al.Effect and mechanism of platycodon grandiflorum polysaccharides regulating macrophages through PDGF/VEGF receptor pathway in improving mucosal damage in ulcerative colitis model mice[J].,2025,54(1):301.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.003]

更新日期/Last Update: 2020-02-17