[1]高旭航,郑玉群,何志杰,等.基因多态性与糖尿病肾病关系研究进展[J].陕西医学杂志,2019,(11):1574-封3.
　GAO Xuhang,ZHENG Yuqun,HE Zhijie,et al.Research progress on relationsship between gene polymorphism and diabetic nephropathy[J].,2019,(11):1574-封3.
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基因多态性与糖尿病肾病关系研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年11期
页码:
1574-封3
栏目:
综述
出版日期:
2019-11-05

文章信息/Info

Title:
Research progress on relationsship between gene polymorphism and diabetic nephropathy
文章编号:
DOI:10.3969/j.issn.10007377.2019.11.046
作者:
高旭航1; 郑玉群2; 何志杰1; 张丽婷1△
1.解放军联勤保障部队第九一〇医院内分泌科（泉州362000）； 2.福建省泉州出入境检验检疫局综合技术服务中心（泉州362000）
Author(s):
GAO Xuhang; ZHENG Yuqun; HE Zhijie; et al.
People’s Liberation Army No. 910 Hospital（Quanzhou 362000）
关键词:
糖尿病肾病; 基因多态性; 发病风险; 预后; 文献综述
Keywords:
Key words Diabetic nephropathy; Gene polymorphism; Risk of disease; Prognosis; Review article
分类号:
R587.2
文献标志码:
A
摘要:
摘 要 糖尿病肾病（DN）是糖尿病慢性并发症之一，在慢性并发症中占有主要地位，可导致晚期肾衰竭，但病因尚未完全阐明。流行病学研究表明，DN的发生发展除与血糖控制水平、病程长短、血压等有关外，还具有遗传易感性。近年来，有相关研究显示多种基因的基因多态性与DN的发生发展存在密切关系。研究显示某些基因的基因型是发生DN的危险因素，而某些基因的基因型与DN的预后相关。目前，基因多态性与DN相关性的研究结论尚不统一或存在争议，研究在进一步深入。
Abstract:
Abstract Diabetic nephropathy （DN） is one of the main chronic complications of diabetes mellitus and currently considered to be the main cause of advanced renal failure，but the etiology has not been fully elucidated. Epidemiological studies have shown that the development of DN is not only related to blood glucose control level，length of course，blood pressure，etc，but also has genetic susceptibility. In recent years，relevant studies have shown that the genetic polymorphisms of multiple genes are closely related to the development of DN. Studies have shown that the genotypes of certain genes are risk factors for DN，and the genotypes of certain genes are associated with the prognosis of DN. At present，the research conclusion of the correlation between gene polymorphism and DN is not uniform or still controversial，and the research is further deepened.

参考文献/References:

[1] Li W，Wang D，Wang X，et al. The association of metabolic syndrome components and diabetes mellitus：evidence from China National Stroke Screening and Prevention Project[J].BMC Public Health，2019，19（1）：192.
[2] Zhang L，Long J，Iang W，et al.Trends in chronic kidney disease in China[J].N Engl J Med，2016，375（9）：905906.
[3] Chang K，Jiang Z，Liu C，et al.The effects of CYP2C19 genotype on the susceptibility for nephrosis in cardiocerebral vascular disease treated by anticoagulation[J].Medicine （Baltimore），2016，95（38）：e4954.
[4] Yang XH，Cao RF，Yu Y，et al. A study on the correlation between MTHFR promoter methylation and diabetic nephropathy[J].Am J Transl Res，2016，8（11）：49604967.
[5] Liu WT，Peng FF，Li HY，et al.Metadherin facilitates podocyte apoptosis in diabetic nephropathy[J].Cell Death Dis，2016，7（11）：e2477.
[6] Susztak K，Raff AC，Schiffer M，et al. Glucoseinduced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy[J].Diabetes，2006，55（1）：225233.
[7] Fawwaz S，Balbaa M，Fakhoury H，et al.Association between angiotensinconverting enzyme insertion/deletion gene polymorphism and endstage renal disease in lebanese patients with diabetic nephropathy[J].Saudi J Kidney Dis Transpl，2017，28（2）：325329.
[8] Yu ZY，Chen LS，Zhang LC，et al.Metaanalysis of the relationship between ACE I/D gene polymorphism and endstage renal disease in patients with diabetic nephropathy[J].Nephrology （Carlton），2012，17（5）：480487.
[9] Lu M，Zhang J，Li M，et al.The angiotensinI converting enzyme gene I/D variation contributes to endstage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis[J].Mol Cell Biochem，2016，422（12）：181188.
[10] Parving HH，de Zeeuw D，Cooper ME，et al.Brenner，ACE gene polymorphism and losartan treatment in type 2 diabetic patients with nephropathy[J].J Am Soc Nephrol，2008，19（4）：771779.
[11] Liu N，Wang Y.Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy：A metaanalysis[J].J Renin Angiotensin Aldosterone Syst，2019，20（1）：1470320318823927.
[12] Ali Z，Kusrini I，Shahab A，et al.Association between A1166C polymorphism of the angiotensin II Type1 receptor gene and Type2 diabetic nephropathy in an Indonesian Malay Population[J].Acta Med Indones，2018，50（4）：314319.
[13] 高妍婷，梁 衍，孙 燕，等肾素血管紧张素系统基因多态性与2型糖尿病患者慢性肾脏病的相关性研究[J].临床肾脏病杂志，2018，18（3）：145149.
[14] Zhuang Y，Niu F，Liu D，et al.Association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy：Evidence from a metaanalysis[J].Medicine （Baltimore），2018，97（41）：e07689.
[15] Zhu H，Yu W，Xie Y，et al.Association of Pentraxin 3 Gene polymorphisms with susceptibility to diabetic nephropathy[J]. Med Sci Monit，2017，23：428436.
[16] Kobori L，Kohalmy K，Porrogi P，et al.Druginduced liver graft toxicity caused by cytochrome P450 poor metabolism[J]. Br J Clin Pharmacol，2008，65（3）：428436.
[17] Wang Z，Gong Y，Zeng DL，et al.Inhibitory Effect of apigenin on losartan metabolism and CYP2C9 activity in vitro[J]. Pharmacology，2016，98（34）：183189.
[18] Li YY，Wang H，Yang XX，et al.AR C106T gene polymorphism and diabetic nephropathy in the Eastern Asians with T2DM：A metaanalysis including 2120 subjects[J].Diabetes Res Clin Pract，2017，130：244251.
[19] Dellamea BS，Pinto LC，Leitao CB，et al.Endothelial nitric oxide synthase gene polymorphisms and risk of diabetic nephropathy：a systematic review and metaanalysis[J].BMC Med Genet，2014，15：9.
[20] Zhou TB，Xu HL，Yin SSAssociation between endothelial nitric oxide synthase Glu298Asp gene polymorphism and diabetic nephropathy susceptibility[J]. Ren Fail，2013，35（1）：173178.
[21] Feng S，Ye G，Bai S，et al.Matrix metalloproteinase9 1562c/t gene polymorphism is associated with diabetic nephropathy[J].Biomed Res Int，2016，2016：1627143.
[22] Ma L，Jiang Y，Kong X，et al.Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes[J].J Hum Genet，2019，64（1）：2328.
[23] Zhou TB，Drummen GB，Jiang ZP，et al.Methylenetetrahydrofolate reductase （MTHFR） C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus[J].Ren Fail，2015，37（8）：12471259.
[24] OniOrisan A，Cresci S，Jones PG，et al.Association between the EPHX2 pLys55Arg polymorphism and prognosis following an acute coronary syndrome[J].Prostaglandins Other Lipid Mediat，2018，138：1522.
[25] Ma L，Yan M，Kong X，et al. Association of EPHX2 R287Q polymorphism with diabetic nephropathy in Chinese type 2 diabetic patients[J].J Diabetes Res，2018 （2018）：2786470.
[26] Egido J，Ortiz AACE gene polymorphism and the prognosis and treatment of overt diabetic nephropathy[J].Nat Clin Pract Nephrol，2008，4（9）：472473.
[27] Yamamoto T，Sato T，Hosoi M，et al.Aldose reductase gene polymorphism is associated with progression of diabetic nephropathy in Japanese patients with type 1 diabetes mellitus[J].Diabetes Obes Metab，2003，5（1）：5157

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更新日期/Last Update: 2019-11-15