[1]魏小兵,董宇为,黄 喆,等.经鼻蝶显微镜与神经内镜垂体瘤切除术治疗垂体瘤疗效比较*[J].陕西医学杂志,2019,(11):1507-1510.
 WEI Xiaobing,DONG Yuwei,HUANG Zhe,et al.Comparison of effects of transsphenoidal microscopy and neuroendoscopic pituitary adenectomy on pituitary adenoma[J].,2019,(11):1507-1510.
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经鼻蝶显微镜与神经内镜垂体瘤切除术治疗垂体瘤疗效比较*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年11期
页码:
1507-1510
栏目:
临床研究
出版日期:
2019-11-05

文章信息/Info

Title:
Comparison of effects of transsphenoidal microscopy and neuroendoscopic pituitary adenectomy on pituitary adenoma
文章编号:
DOI:10.3969/j.issn.10007377.2019.11.027
作者:
魏小兵董宇为黄 喆李国强谯 进△
陕西省汉中市中心医院神经外科(汉中 723000)
Author(s):
WEI XiaobingDONG YuweiHUANG Zheet al
Neurosurgery,Hanzhong Central Hospital in Shaanxi Province(Hanzhong 723000)
关键词:
显微镜神经内镜垂体瘤切除术嗅觉功能视觉功能对比研究
Keywords:
Key words MicroscopyNeuroendoscopyPituitary adenectomyOlfactory functionVisual functionComparative study
分类号:
R73941
文献标志码:
A
摘要:
摘 要 目的:探讨经鼻蝶显微镜与神经内镜垂体瘤切除术治疗垂体瘤的效果。方法:收录垂体瘤患者90例,均行经鼻蝶入路垂体瘤切除术,根据手术方式不同分为神经内镜组(n=49)和显微镜组(n=41)。比较两组患者围术期指标(术中出血量、手术时间、住院时间)、肿瘤切除、复发情况、术后并发症发生率等差异性,观察手术前后嗅觉功能(嗅觉识别阈值)、视觉功能\[视野平均缺损(MD)、模式标准差(PSD)、加权视野指数(VFI)\]、激素水平\[泌乳素(PRL)、生长激素(GH)、促肾上腺皮质激素(ACTH)\]变化情况。结果:神经内镜组患者术中出血量少于显微镜组,手术时间、住院时间均短于显微镜组(P<005),肿瘤全切率高于显微镜组,术后并发症发生率和术后1年复发率低于显微镜组(P<005);术后3周,两组患者嗅觉识别阈值均较术前升高,且显微镜组高于神经内镜组(P<005),MD、PSD和血清PRL则较术前降低,VFI则较术前升高,且神经内镜组改善程度高于显微镜组(P<005);术后3周,两组患者血清GH、ACTH水平均较术前降低(P<005),但组间比较差异无统计学意义(P>005)。结论:与经鼻蝶显微镜垂体瘤切除术比较,神经内镜下手术切除垂体瘤效果更佳,并发症和复发情况更少见,且手术创伤小,节省手术时间和住院时间,更有利于嗅觉、视觉功能和激素水平恢复正常。
Abstract:
Abstract Objective:To explore the effects of transsphenoidal microscopy and neuroendoscopic pituitary adenectomy in the treatment of pituitary adenoma Methods:The clinical data of 90 patients admitted with pituitary adenoma were retrospectively analyzed All patients underwent transsphenoidal approach for pituitary adenectomy,and they were divided into neuroendoscopy group (n=49) and microscopy group (n=41) according to different surgical methodsThe perioperative indexes (intraoperative blood loss,operative time,hospital stay),tumor resection,recurrence and incidence rate of postoperative complications were compared between the two groups The olfactory function (olfactory recognition threshold),visual function \[visual field mean defect (MD),pattern standard deviation (PSD),weighted visual field index (VFI)\] and hormones levels \[prolactin (PRL),growth hormone (GH),adrenocorticotropic hormone (ACTH)\]were observed before and after operation Results:The intraoperative blood loss in neuroendoscopy group was less than that in microscopy group,and the operative time and hospital stay were shorter than those in microscopy group (P<005),and the total tumor resection rate was higher than that in microscopy group,and the incidence rate of postoperative complications and recurrence rate at 1 year after operation were lower than those in microscopy group (P<005) At 3 weeks after operation,the olfactory recognition threshold in the two groups was increased compared with that before operation,and the threshold in microscopy group was higher than that in neuroendoscopy group (P<005),and the MD,PSD and serum PRL were decreased compared with those before operation while the VFI was increased compared with that before operation,and the improvements in neuroendoscopy group were higher than those in microscopy group (P<005)  At 3 weeks after operation,the levels of serum GH and ACTH in the two groups were decreased compared with those before operation (P<005),but there were no significant differences between the groups (P>005) Conclusion:Compared with transsphenoidal mi〖LM〗croscopy for pituitary adenectomy,neuroendoscopic surgery for pituitary adenoma resection has better effects,less common complications and recurrence and small surgical trauma,and it can save operative time and hospital stay,and it is more conducive to normal recovery of olfactory,visual function and hormone levels

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备注/Memo

备注/Memo:
*陕西省卫生健康委员会科研基金资助项目(2018YL8015063)
更新日期/Last Update: 2019-11-15