[1]郭武玲,杨欣伟,刘 瑶,等.抽动障碍患儿脑电图变化及可乐定透皮帖治疗效果研究[J].陕西医学杂志,2019,(10):1369-1373.
　GUO Wuling,YANG Xinwei,LIU Yao,et al.Study on electroencephalogram changes and therapeutic effect of〖JZ〗 clonidine scalp patch in children with Tic Disorders[J].,2019,(10):1369-1373.
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抽动障碍患儿脑电图变化及可乐定透皮帖治疗效果研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年10期
页码:
1369-1373
栏目:
临床研究
出版日期:
2019-10-05

文章信息/Info

Title:
Study on electroencephalogram changes and therapeutic effect of〖JZ〗 clonidine scalp patch in children with Tic Disorders
文章编号:
DOI:10.3969/j.issn.10007377.2019.10.035
作者:
郭武玲; 杨欣伟; 刘 瑶; 吴华杰△
空军军医大学西京医院儿科（西安 710032）
Author(s):
GUO Wuling; YANG Xinwei; LIU Yao; et al.
Department of Pediatrics of Xijing Hospital,Air Force Military Medical University(Xi’an 710032)
关键词:
抽动障碍; 可乐定透皮贴; 脑电图; 耶鲁抽动量表; 儿童
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Tic Disorders; Clonidine transdermal patch; Electroencephalogram; Yale Global Tic Severity Scale; Child
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 目的：分析298例抽动障碍（TD）患儿脑电图变化，并观察可乐定透皮贴治疗儿童抽动障碍的疗效。方法:收集TD抽动障碍患儿298例，分为观察组（可乐定透皮贴）及对照组（硫必利），观察两组脑电图变化，并采用耶鲁抽动量表（YGTSS）对患儿用药前及用药后进行评分。结果:298例TD儿童中脑电图异常47例，占所有患儿15.8%，脑电图异常TD组及脑电图正常TD组治疗前及治疗后YGTSS比较差异无统计学意义（P＞0.05）。可乐定透皮贴治疗8周后TD患儿YGTSS减分率在运动性抽动积分、发声性抽动积分、功能受损积分及总分方面均较治疗前明显下降，差异存在统计意义（P＜0.05）。观察组与对照组在治疗前及治疗后YGTSS比较无统计学差异（P＞0.05）。结论:脑电图检查可提高TD儿童的诊断率，但脑电图异常与抽动症状的严重程度和是否共患癫痫无明显关联。可乐定透皮贴作为一种新型的治疗TD儿童的药物，安全、有效、副作用少。 
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objective:To analyze the electroencephalogram (EEG) changes and observe the therapeutic effect of clonidine transdermal patch on 298 children with Tic Disorder(TD).Methods:Children with tic disorder diagnosed were collected.They were divided into observation group (clonidine transdermal patch) and control group (thiourea).The changes of electroencephalogram (EEG) and the Yale Global Tic Severity Scale (YGTSS) was used to evaluate the children before and after medication.Results:Among 298 children with TD,47 had abnormal EEG,accounting for 15.8% of all children.There was no significant difference in YGTSS between abnormal EEG TD group and normal EEG TD group before and after treatment（P＞0.05）.In motor tic,vocal tic,functional impairment scores and total score,the reduction rate of YGTSS score in children with TD after 8 weeks of treatment with clonidine transdermal patch were significantly lower than before treatment (P＜0.05).There was no significant difference in YGTSS between the observation group and the control group before and after treatment (P＞0.05).Conclusions:EEG can be used to improve the diagnostic rate of children with TD,but EEG abnormality has no significant correlation with the severity of tic symptoms and whether they are cosuffered with epilepsy or not.Clonidine transdermal patch,as a new drug for children with TD,is safe,effective and has few side effects.It is worthy of clinical promotion.

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更新日期/Last Update: 2019-10-23