[1]史鲁东,胡 伟△.冠脉介入联合替格瑞洛对心肌梗死患者血清〖JZ〗巨噬细胞移动抑制因子、白细胞介素10的影响研究[J].陕西医学杂志,2019,(10):1336-1338.
　SHI Ludong,HU Wei..Effect of ticagrelor combined with coronary intervention 〖JZ〗on serum MIF and IL10 in patients with myocardial infarction[J].,2019,(10):1336-1338.
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冠脉介入联合替格瑞洛对心肌梗死患者血清〖JZ〗巨噬细胞移动抑制因子、白细胞介素10的影响研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年10期
页码:
1336-1338
栏目:
临床研究
出版日期:
2019-10-05

文章信息/Info

Title:
Effect of ticagrelor combined with coronary intervention 〖JZ〗on serum MIF and IL10 in patients with myocardial infarction
文章编号:
DOI:10.3969/j.issn.10007377.2019.10.025
作者:
史鲁东; 胡 伟△
复旦大学附属中山医院闵行医院(上海市闵行区中心医院) ( 上海 201100 )
Author(s):
SHI Ludong;  HU Wei.
Zhongshan Hospital Affiliated to Fudan University Minhang 〖JZ〗Hospital(Shanghai Minhang District Central Hospital)（Shanghai 201100)
关键词:
替格瑞洛; 冠脉介入; 心肌梗死; 巨噬细胞移动抑制因子; 白细胞介素10; 对比研究
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Ticagrelor; Coronary intervention; Myocardial infarction; Macrophage migration inhibitory factor; Interleukin10; Comparative study
分类号:
R541.4
文献标志码:
A
摘要:
摘 要 目的：探讨冠脉介入联合替格瑞洛对心肌梗死患者血清巨噬细胞移动抑制因子（MIF）、白细胞介素10（IL10）的影响研究。 方法：选取64例急性心肌梗死患者随机分成对照组和观察组，经冠脉介入治疗后，对照组口服氯吡格雷，观察组口服替格瑞洛，比较两组患者不良反应发生率、血管再通率、冠状动脉狭窄程度（TIMI）与心肌灌注（TMP）分级、治疗前后血清MIF、IL10水平。 结果：观察组与对照组不良事件发生率分别为12.50%与15.62%，血管再通率为93.75%与87.50%，差异无统计学意义（P＞0.05）。治疗后观察组TIMI与TMP中23级的占比显著高于对照组（P ＜0.05）。治疗后两组MIF水平均下降，IL10均上升，但观察组MIF下降幅度与IL10上升幅度更大（P＜ 0.05）。结论：冠脉介入联合替格瑞洛能有效抑制炎症反应，提高血流分级与心肌灌注分级，血管再通率高，不良事件少，值得应用。
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objective：To investigate the effects of ticagrelor combined with coronary intervention on the therapeutic effects of serum MIF and IL10 in patients with myocardial infarction.Methods： Sixtyfour patients with acute myocardial infarction were randomly divided into the control group and the observation group.After coronary intervention,the control group received oral clopidogrel and the observation group received oral ticagrelor.The incidence of adverse reactions,vascular recanalization rate,TIMI,TMP,serum MIF and IL10 levels were compared between the two groups.Results:The incidence of adverse events in the observation group and the control group were 12.50% and 15.62%,respectively,and the recanalization rate was 93.75% and 87.50%.The difference was not statistically significant (P > 0.05).The proportion of TIMI and TMP in the observation group was significantly higher than that in the control group (P＜0.05).After treatment,the MIF levels of the two groups decreased,and IL10 increased,however,the MIF decline and the increase in IL10 in the observation group were greater(P＜0.05).Conclusion:ticagrelor combined with coronary intervention can effectively inhibit the inflammatory response,effectively improve the blood flow classification and myocardial perfusion grading,with high recanalization rate and few adverse events,which is worthy of promotion.

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更新日期/Last Update: 2019-10-23