[1]王自强,贾利敏,赵 翠.血栓弹力图评价阿魏酸哌嗪联合阿司匹林对不典型膜性〖JZ〗肾病抗凝治疗的效果研究*[J].陕西医学杂志,2019,(9):1178-1181.
　WANG Ziqiang,JIA Limin,ZHAO Cui..To evaluate the anticoagulant effect of piperazine ferulate combined with aspirin〖JZ〗on patients with atypical membranous nephropathy by Thrombelastogram[J].,2019,(9):1178-1181.
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血栓弹力图评价阿魏酸哌嗪联合阿司匹林对不典型膜性〖JZ〗肾病抗凝治疗的效果研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1178-1181
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
To evaluate the anticoagulant effect of piperazine ferulate combined with aspirin〖JZ〗on patients with atypical membranous nephropathy by Thrombelastogram
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2019.09.019
作者:
王自强; 贾利敏;  赵 翠
河北省沧州市人民医院肾内科（沧州 061000）
Author(s):
WANG Ziqiang; JIA Limin; ZHAO Cui.
Department of Nephrology，Cangzhou People’s Hospital， Hebei Province（Cangzhou 061000）
关键词:
不典型膜性肾病; 血栓弹力图; 阿魏酸哌嗪; 阿司匹林; 抗凝
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Atypical membranous nephropathy; Thrombelastogram; Piperazine ferulate; aspirin; Antifreezing
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 〖HT5K〗目的：通过血栓弹力图评价阿魏酸哌嗪联合阿司匹林对不典型膜性肾病患者的抗凝效果，并评估其对临床疗效及不良反应。方法：选取肾活检确诊为不典型膜性肾病患者63例，常规予泼尼松、环磷酰胺及降压、降脂、利尿等综合治疗，将其随机分为两组。试验组32例门诊治疗期间联合应用阿魏酸哌嗪及阿司匹林抗凝治疗，常规组31例门诊治疗期间单用阿司匹林抗凝治疗。治疗4周，检测治疗前后血栓弹力图指标 (反应时间R值、凝血块形成时间K值、凝固角α角、血栓最大弹力度MA、凝血指数 CI)、血清白蛋白、肌酐、总胆固醇、甘油三脂及 24 h 尿蛋白定量。同时选取同期健康体检者10例为对照组。结果：治疗前，63例不典型膜性肾病患者R值、K值较对照组降低，α角、MA、CI较对照组升高，差异均有统计学意义（P＜0.05）。治疗前后相比较，试验组R值、K值较治疗前升高，α 角、CI较治疗前降低，差异有统计学意义（P＜0.05），MA值治疗前后未见明显差异。两组间比较，试验组治疗后R值、K值、α 角、CI改善更显著（P＜0.05），差异有统计学意义。两组生化指标比较，均较治疗前改善（P＜0.05），但试验组改变更显著，两组间比较差异有统计学意义（P＜0.05）。从出血不良反应来看，两组间对比无明显区别（P＞0.05），差异无统计学意义。结论：阿魏酸哌嗪联合阿司匹林在抗凝方面优于单用阿司匹林，且不增加不良反应，并可促进病情缓解及改善预后。
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objective：The anticoagulant effect of piperazine ferulate combined with aspirin on patients with atypical membranous nephropathy was evaluated by thrombelastogram，and its clinical efficacy and adverse reactions were evaluated. Methods：Sixtythree patients with atypical membranous nephropathy confirmed by renal biopsy were selected. The patients was randomly divided into experimental group and regular group. The experimental group consisted of 32 patients，who were treated with piperazine ferulic acid and aspirin. 31 patients in the conventional group were treated with aspirin alone. They were treated for four weeks. Before and after treatment，indicators of thrombus elasticity (R value of reaction time，K value of clot formation time，coagulation Angle Angle，MA of maximum thrombus elasticity，CI of coagulation index)，serum albumin，creatinine，total cholesterol，triglyceride and 24 h urine protein quantification were tested. Results：Before treatment，the R and K values of 63 patients with atypical membranous nephropathy were lower than those of the control group，and the values of，MA and CI were higher than those of the control group，with statistically significant differences (P＜0.05). The R value and K value of the experimental group were higher than that before treatment，and the α Angle and CI value were lower than that before treatment，the difference was statistically significant (P＜0.05)，and there was no significant difference in MA before and after treatment.Compared between the two groups，the improvement of R value，K value，alpha Angle and CI in the experimental group was more significant after treatment (P＜0.05)，and the difference was statistically significant. Biochemical indexes of the two groups were improved compared with those before treatment (P＜0.05)，but the changes in the experimental group were more significant，and the differences between the two groups were stati〖LM〗stically significant (P＜0.05). From the results of adverse reactions to bleeding，there was no significant difference between the two groups (P＞0.05)，and the difference was not statistically significant. Conclusion：piperazine ferulate combined with aspirin is better than aspirin alone in anticoagulation，and does not increase adverse reactions，and can promote disease remission and improve prognosis.

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备注/Memo

备注/Memo:
*河北省沧州市重点研发计划指导项目（172302122）
更新日期/Last Update: 2019-09-24