[1]王晓东,张 涛△ ,崔 凯,等.术前外周血小板计数与淋巴细胞计数比值对非小细胞肺癌根治术后〖JZ〗并辅助化疗患者预后的影响[J].陕西医学杂志,2019,(9):1147-1150.
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术前外周血小板计数与淋巴细胞计数比值对非小细胞肺癌根治术后〖JZ〗并辅助化疗患者预后的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1147-1150
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2019.09.011
作者:
王晓东; 张 涛△ ; 崔 凯; 梁晓华; 赵 芳; 李小飞
空军军医大学第二附属医院胸外科六病区（西安710038）
关键词:
血小板计数; 淋巴细胞计数; 预后因素; 非小细胞癌; 手术; 化学疗法
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 〖HT5K〗目的：探讨术前外周血小板计数与淋巴细胞计数比值（PLR）对术后并辅助化疗的非小细胞肺癌（NSCLC）患者预后的影响。方法：收集行根治性手术并术后辅助化疗的非小细胞肺癌患者108例，应用ROC曲线分析确定对患者生存结局有预测意义的最佳PLR值，以此值为界限划分为PLR高组及PLR低组，应用COX比例风险回归模型进一步行多因素分析以验证PLR是否为术后并辅助化疗非小细胞肺癌患者的独立预后因素；如果为其独立预后因素，应用KaplanMeier计算总生存时间（OS）及无疾病生存时间（DFS），应用Logrank法对比NLR高组与NLR低组两组患者的生存差异是否有统计学意义。结果：PLR对患者死亡的预测有意义的最佳值为137.12，AUC为0.728（95%CI：0.616~0.760，P=0.035）。将资料分为PLR＜137.12和PLR≥137.12两组。COX多因素分析分析显示，术前PLR为术后并辅助化疗非小细胞肺癌患者的独立不良预后因素，RR1.747，95%CI（1.029~2.966），P=0.039。Logrank生存比较显示，低PLR组中位OS54个月，95%CI（27.622~80.378），高PLR组中位OS36个月，95%CI（18.585~53.415），P=0.036。结论：术前PLR可能是根治术后并辅助化疗NSCLC患者的独立不良预后因素。术前高PLR可能预示较短的总生存时间。

参考文献/References:

[1] 〖ZK（#〗Hainsworth JD CC，Kanarev V，Ciuleanu TE,et al. A phase II，openlabel，randomized study to assess the efficacy and safety of AZD6244 (ARRY142886) versus pemetrexed in patients with nonsmall cell lung cancer who have failed one or two prior chemotherapeutic regimens[J] . Journal of Thoracic Oncology，2010,5(10):16301636.
[2] Siegel RL，Miller KD，Jemal A. Cancer statistics，2015[J] . CA:Cancer Journal for Clinicians，2015，65(1):529.
[3] Goldstraw PCJ，Chansky K，Giroux DJ，et al. The IASLC lung cancer staging project：proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours[J] . J Thorac Oncol,2007,2(7)：593602.
[4] Wen J，Bedford M，Begum R，et al. The value of inflammation based prognostic scores in patients undergoing surgical resection for oesophageal and gastric carcinoma[J] . Journal of Surgical Oncology,2018,5:14.
[5] Vernieri C，Mennitto A，Prisciandaro M，et al. The neutrophiltolymphocyte and platelettolymphocyte ratios predict efficacy of platinumbased chemotherapy in patients with metastatic triple negative breast cancer[J] .Scientific Reports,2018,8(1):8703.
[6] Lee BM，Chung SY，Chang JS，et al. The neutrophillymphocyte ratio and plateletlymphocyte ratio are prognostic factors in patients with locally advanced pancreatic cancer treated with chemoradiotherapy[J] . Gut and Liver,2018,12(3):342352.
[7] Toda M，Tsukioka T，Izumi N，et al. Platelettolymphocyte ratio predicts the prognosis of patients with nonsmall cell lung cancer treated with surgery and postoperative adjuvant chemotherapy[J] .Thoracic Cancer,2018,9(1):112119.
[8] Menter DG，Tucker SC，Kopetz S，et al. Platelets and cancer：a casual or causal relationship：revisited[J] . Cancer Metastasis Reviews,2014,33(1):231269.
[9] He AD，Xie W，Song W，et al. Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6[J] . Scientific Reports,2017,7(1):3989.〖ZK)〗
[10] 〖ZK(#〗Sun WW，Xu ZH，Lian P，et al. Characteristics of circulating tumor cells in organ metastases，prognosis，and T lymphocyte mediated immune response[J] . Onco Targets and Therapy,2017,10:24132424.
[11] Akinci OB，Sahin OT，Buyukyaylaci OS，et al. Prognostic value of the neutrophil to lymphocyte ratio (nlr) in lung cancer cases[J] .Asian Pacific Journal of Cancer Prevention,2017,18(5):14171421.
[12] Lv Y，Pan Y，Dong C，Liu P，et al. Modified glasgow prognostic score at recurrence predicts poor survival in resected nonsmall cell lung cancer (NSCLC) patients[J] . Medical Science Monitor:International Medical Journal of Experimental and Clinical Research,2017,23:37803788.
[13] 江冠铭,刘克军,谭钦全,等.血小板与淋巴细胞比值在表皮生长因子受体突变型非小细胞肺癌靶向治疗疗效与预后评价中的价值[J] .实用医学杂志,2019,35(4):533536.
[14] Kim SH，Lee HW，Go SI,et al. Clinical significance of the preoperative platelet count and platelettolymphocyte ratio (PLTPLR) in patients with surgically resected nonsmall cell lung cancer[J] .Oncotarget,2016,7(24):3619836206.

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更新日期/Last Update: 2019-09-24