[1]冯 涛,王宗社,舒端朝,等.主动脉瘤患者围术期基质金属蛋白酶、基质金属蛋白酶抑制因子、 白细胞介素检测及临床意义*[J].陕西医学杂志,2019,(8):1094-1097.
　FENG Tao,WANG Zongshe,SHU Duanchao,et al.Study on the change of MMP,TIMP and IL indexes of patients with aortic aneurysm  during the perioperative period[J].,2019,(8):1094-1097.
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主动脉瘤患者围术期基质金属蛋白酶、基质金属蛋白酶抑制因子、 白细胞介素检测及临床意义*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1094-1097
栏目:
临床检验
出版日期:
2019-08-05

文章信息/Info

Title:
Study on the change of MMP,TIMP and IL indexes of patients with aortic aneurysm  during the perioperative period
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.038
作者:
冯 涛; 王宗社; 舒端朝; 张顺军△
陕西省宝鸡市中心医院心血管外科（宝鸡721008）
Author(s):
FENG Tao; WANG Zongshe; SHU Duanchao; et al.
Department of Cardiovascular Surgery,Baoji Center Hospital in Shaanxi Province（Baoji 721008）
关键词:
主动脉瘤; 围术期; 基质金属蛋白酶; 基质金属蛋白酶抑制因子; 白细胞介素; 对比研究
Keywords:
Key words Aortic aneurysm; Perioperative period; Matrix metalloproteinase; Matrix metalloprotease inhibitors;  Interleukinin interleukinin;  Comparative study
分类号:
R654.2
文献标志码:
A
摘要:
摘 要 目的：探讨主动脉瘤患者围术期基质金属蛋白酶（MMP）、基质金属蛋白酶抑制因子（TIMP）及白细胞介素（IL）等指标的变化情况。方法：选取手术治疗的30例主动脉瘤患者为观察组，并选取同时间段同年龄段的30例体检健康者为对照组，然后将观察组患者术前1 d及术后1、3、7、14 d及对照组的血清MMP（MMP-1、MMP-2、MMP-3、MMP-8、MMP-9、MMP-13）、TIMP（TIMP-1、TIMP-2、TIMP-3）及IL（IL-1β、IL-4、IL-6、IL-8及IL-10）相关指标进行分别检测及比较。结果：术前1 d，观察组血清MMP-1、MMP-2、MMP-3、MMP-8、MMP-9、MMP-13、TIMP-1、TIMP-2、TIMP-3、IL-1β、IL-4、IL-6、IL-8及IL-10水平均显著高于对照组受检者（P＜0.05）。术后1 d，观察组上述各项血清MMP及TIMP指标水平均有所下降，血清IL指标水平略有升高，但与术前比较差异无统计学意义（P＞0.05）；随着恢复时间延长，观察组术后3、7、14 d血清MMP及TIMP相关指标水平均呈现明显下降趋势（P＜0.05）；但直到术后14 d时，观察组血清MMP及TIMP相关指标水平仍显著高于对照组受检者（P＜0.05）。术后1～3 d，上述血清IL指标水平进一步升高，且在术后3 d达到最高水平（P＜0.05）；术后7、14 d，上述血清IL指标水平显著下降（P＜0.05）；直到术后14 d血清IL指标水平基本恢复至对照组受检者水平（P＞0.05）。结论：主动脉瘤患者围术期MMP、TIMP及IL指标的变化较大，其中MMP及TIMP呈现持续降低的趋势，而IL则呈现先升后降的趋势。MMP、TIMP及IL参与了主动脉瘤形成,ECM降解及炎症反应在主动脉瘤发生发展过程中扮演重要角色。
Abstract:
Abstract Objective:To study and observe the change situation of MMP(Matrix metalloproteinase),TIMP(Inhibitor of Matrix Metalloprotease) and IL(Interleukin) indexes of patients with aortic aneurysm during the perioperative period.Methods:30 patients with aortic aneurysm who were were selected as observation group,30 healthy persons with health examination and the same ages at the same time were selected as control group,then the serum MMP(MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13),TIMP(TIMP-1, TIMP-2, TIMP-3) and IL(IL-1β, IL-4, IL-6, IL-8, IL-10) related indexes of observation group at 1d before the operation and at 1day,3day,7day and 14day after the operation and control group were respectively detected and compared.Results:In the first day before surgery, the levers of serum MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3, IL-1β, IL-4, IL-6, IL-8, IL-10 in the observation group were significantly higher than the control group (P <0.05).At 1 day after operation, the levels of serum MMP and TIMP in the observation group decreased, and the serum IL level increased slightly, but the difference was not significant (P>0.05).With the prolongation of recovery time, the levels of serum MMP and TIMP in the observation group showed a significant downward trend at 3day, 7day and 14day after operation (P＜0.05).However, at 14 days after operation, the levels of serum MMP 〖LM〗and TIMP in the observation group were still significantly higher than those in the control group (P＜0.05).The serum IL level was further increased 1 to 3 days after surgery, and reached the highest level after 3d (P<0.05).At 7 and 14 days after operation, the serum IL level was significantly decreased (P＜0.05). The level of serum IL was basically restored to the level of the control group at 14 days after operation (P>0.05).Conclusion:The change of MMP，TIMP and IL indexes of patients with aortic aneurysm during the perioperative period are great，and the MMP and TIMP related indexes show a decreasing trend，while the IL show trend of increasing first and decreasing afterward.

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备注/Memo

备注/Memo:
*陕西省社会发展科技攻关项目(2010SF1012)
更新日期/Last Update: 2019-08-13