[1]杨 勇,王 冰△.人绒毛膜促性腺激素、人附睾蛋白4、糖类抗原199联合检测对卵巢肿瘤的诊断价值[J].陕西医学杂志,2019,(8):1091-1093,1101.
　YANG Yong,WANG Bing..The diagnostic value of β-HCG,HE4, CA199 joint detection for ovarian neoplasms[J].,2019,(8):1091-1093,1101.
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人绒毛膜促性腺激素、人附睾蛋白4、糖类抗原199联合检测对卵巢肿瘤的诊断价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1091-1093,1101
栏目:
临床检验
出版日期:
2019-08-05

文章信息/Info

Title:
The diagnostic value of β-HCG,HE4, CA199 joint detection for ovarian neoplasms
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.037
作者:
杨 勇1; 王 冰2△
1.陕西省安康市中心医院核医学科（安康725000）;2.陕西省安康市中心医院妇科（安康725000）
Author(s):
YANG Yong; WANG Bing.
Department of Nuclear Medicine, Ankang Central Hospital in Shaanxi Province（Ankang 725000）
关键词:
人绒毛膜促性腺激素; 人附睾蛋白4; 糖类抗原199; 联合检测; 卵巢肿瘤; 诊断价值
Keywords:
Key words Human chorionic gonadotrophin; Humanepididymis secretory protein4;  Carbohydrate antigen 199; Joint detection; Ovarian neoplasms;  Diagnostic value
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 目的：研究人绒毛膜促性腺激素（β-HCG）、人附睾蛋白4（HE4）、糖类抗原199（CA199）联合检测对卵巢肿瘤的诊断价值。方法：选择卵巢肿瘤患者143例作为观察对象。按照术后病理结果分成卵巢癌组68例和良性肿瘤组75例，另选同期接受健康体检的女性志愿者70例作为对照组。对比各组β-HCG、HE4、CA199水平，β-HCG、HE4、CA199单独及联合检测的阳性率，以及分析三者对卵巢癌的诊断价值。结果：卵巢癌组及良性肿瘤组的β-HCG、HE4、CA199水平均分别高于对照组，且卵巢癌组高于良性肿瘤组（P＜0.05）。β-HCG、HE4、CA199联合检测卵巢癌的阳性率为89.71%，明显高于良性肿瘤组的48.00%及对照组的2.86%（P＜0.05）。经ROC曲线分析发现，β-HCG、HE4、CA199联合诊断卵巢癌的价值最高，其灵敏度为82.34%，准确度为89.71%,曲线下面积为0.713。结论：β-HCG、HE4、CA199联合检测对卵巢肿瘤的诊断价值较高，值得引起临床的重视。
Abstract:
Abstract Objective: To study diagnostic value of human chorionic gonadotropin (β-HCG),human epididymal protein 4 (HE4), carbohydrate antigen 199 (CA199) joint detection for ovarian neoplasms.Methods: 143 patients with ovarian neoplasms undergoing pelvic mass examination were selected as observation objects. According to the postoperative pathological results, 68 cases of ovarian cancer group and 75 cases of benign tumor group were divided into two groups. 70 female volunteers who received physical examination at the same time were selected as the control group. The level of β-HCG,HE4,CA199 and the positive rate of β-HCG,HE4,CA199 in each group were compared, and the diagnostic value of β-HCG,HE4,CA199 in ovarian cancer was analyzed.Results: The levels of β-HCG,HE4,CA199 in ovarian cancer group and benign tumor group were significantly higher than the control group, and the level of β-HCG,HE4,CA199 in ovarian cancer group was significantly higher than the benign tumor group (P<0.05). The positive rate of β-HCG,HE4,CA199 in ovarian cancer was 89.71%, which was significantly higher than the benign tumor group of 48.00% and control group of 2.86% (P<0.05). The value of β-HCG,HE4,CA199 joint detection of ovarian cancer was found to be the highest by ROC curve analysis, the sensitivity was 82.34%, the accuracy was 89.71%, and the area under the curve was 0.713. Conclusion: The joint detection of β-HCG,HE4,CA199 is valuable in the diagnosis of ovarian neoplasms. It is worth paying attention to in clinic.

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更新日期/Last Update: 2019-08-13