[1]宋红波.肾综合征出血热患者血清同型半胱氨酸、胱抑素C水平检测及临床意义*[J].陕西医学杂志,2019,(8):1085-1087.
　SONG Hongbo..Detection of serum homocysteine level in patients with hemorrhagic fever with renal syndrome and its clinical significance[J].,2019,(8):1085-1087.
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肾综合征出血热患者血清同型半胱氨酸、胱抑素C水平检测及临床意义*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1085-1087
栏目:
临床检验
出版日期:
2019-08-05

文章信息/Info

Title:
Detection of serum homocysteine level in patients with hemorrhagic fever with renal syndrome and its clinical significance
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.035
作者:
宋红波
西安市第八医院(西安 710061)
Author(s):
SONG Hongbo.
The Eighth Hospital of Xi’an( Xi’an 710061)
关键词:
肾综合征; 出血热; 同型半胱氨酸; 胱抑素C; 诊断; 对比研究
Keywords:
Key words Renal syndrome;  Hemorrhagic fever; Homocysteine; Systatin C;  Diagnosis;  Comparative study
分类号:
R512.8
文献标志码:
A
摘要:
摘 要 目的：评价肾综合征出血热患者血清同型半胱氨酸（Hcy）、胱抑素C（Cys-C）水平变化及临床意义。方法：对肾综合征出血热（HFRS）组105例患者血清Hcy、Cys-C水平进行测定，40例健康受试者组成正常对照组，将两组检测结果进行比较分析。结果：经检测，HFRS组患者血清Hcy、Cys-C水平在发热期、少尿期、恢复期等各病程阶段均显著升高，尤以少尿期最高，与正常对照组比较，差异均具有统计学意义（P＜0.05）；HFRS组各病情状态患者在轻型、中型、重型、危重型等病情状态血清Hcy、Cys-C水平在少尿期阶段均显著升高，尤以危重型最高，均显著高于正常对照组，比较差异均具有统计学意义（P＜0.05）；此外HFRS组少尿期患者血清Hcy与Cys-C之间呈明显的正性相关（P＜0.05）。结论：检测HFRS患者血清Hcy、Cys-C水平对患者疾病诊治及探讨其发病机制具有重要的临床意义。
Abstract:
Abstract Objective: To evaluate the changes and clinical significance of serum homocysteine (Hcy) and cystatin C (Cys-C) levels in patients with hemorrhagic fever with renal syndrome. Methods: Serum levels of Hcy and Cys-C were measured in 105 patients with hemorrhagic fever with renal syndrome (HFRS)，and 40 healthy subjects were divided into normal control group. The results of the two groups were compared and analyzed. Results: The serum levels of Hcy and Cys-C in HFRS group were significantly increased in fever，oliguria and convalescence stages，especially in oliguria stage，with significant difference compared with normal control group (P＜0.05). The serum levels of Hcy and Cys-C in HFRS group were significantly increased in mild，moderate，severe，critical and other conditions during oliguria stage. The levels of serum Hcy and Cys-C in patients with oliguria in HFRS group were significantly higher than those in normal control group (P＜0.05)，and there was a significant positive correlation between serum Hcy and Cys-C in patients with oliguria (P＜0.05). Conclusion: Detection of serum Hcy and Cys-C levels in HFRS patients has important clinical significance in diagnosis and treatment of HFRS and in exploring its pathogenesis.

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备注/Memo

备注/Memo:
*西安市卫生和计划生育委员会课题（J2014018）
更新日期/Last Update: 2019-08-13