[1]张绎平,韩亚荣△,刘云霞 ,等.血液透析联合血液灌流治疗尿毒症脑病效果及对患者血清脑源性神经营养因子和神经肽Y的影响[J].陕西医学杂志,2019,(8):1028-1031.
　ZHANG Yiping,HAN Yarong,LIU Yunxia,et al.Effect and changes of BDNF and NPY in patients with uremic encephalopathy by  hemodialysis combined hemoperfusion[J].,2019,(8):1028-1031.
点击复制

血液透析联合血液灌流治疗尿毒症脑病效果及对患者血清脑源性神经营养因子和神经肽Y的影响

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1028-1031
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Effect and changes of BDNF and NPY in patients with uremic encephalopathy by  hemodialysis combined hemoperfusion
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.019
作者:
张绎平1; 韩亚荣2△; 刘云霞3 ; 张宝桐3; 任丽丽3; 郭冬慈3 ; 吴 丹3; 富 丽
1.锦州医科大学研究生学院 (锦州121000);2.锦州医科大学附属第一医院血液透析室(锦州121000); 3.辽宁省辽阳市中心医院血液透析室（辽阳111000）
Author(s):
ZHANG Yiping;  HAN Yarong;  LIU Yunxia;  et al.
Graduate School,Jinzhou Medical University（Jinzhou 121000）
关键词:
尿毒症脑病; 治疗; 血液透析; 血液灌流; 脑源性神经营养因子; 神经肽Y
Keywords:
Key words Uremic encephalopathy ; Therapy; Hemodialysis; Hemoperfusion; Brain-derivedneurotrophicfactor;  Neuropeptide Y
分类号:
R692.5
文献标志码:
A
摘要:
摘 要 目的:探讨血液透析（HD）联合血液灌流（HP）对尿毒症脑病的治疗效果，同时观察血清中脑源性神经营养因子（BDNF）和神经肽Y（NPY）含量的变化。方法:选择94例尿毒症脑病患者，随机分为两组，每组各47例，对照组应用HD治疗，观察组应用HD+HP治疗。分别于治疗前、后检测血清中血尿素氧（BUN）、血肌酐（Scr）、全段甲状旁腺激素（iPTH）、β2-微球蛋白（β2-MG）、BDNF和NPY的水平。结果: 观察组的总有效率80.9%明显高于对照组的61.7%（χ2＝4.209，P＜0.05）,两组治疗后BUN、Scr、iPTH和β2-MG均下降，但是观察组的下降值更明显。两组治疗后BDNF和NPY均升高，但是观察组的升高值更明显。结论:尿毒症脑病患者应用HD+HP治疗的效果明显，对清除尿毒症毒素，提高治疗效果有明显价值，同时能调节血清中BDNF和NPY的含量。
Abstract:
Abstract Objective：To investigate the therapeutic effect,changes of serum brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) in patients with uremic encephalopathy by hemodialysis(HD) combined with hemoperfusion(HP).Methods:94 patients with uremic encephalopathy were divided into two groups according to the order of admission（47 cases of each group）. The control group was treated with HD, the observation group was treated with HD and HP. Serum levels of BUN, Scr, iPTH, beta2-microglobulin (beta2-MG), BDNF and NPY were detected before and after treatment. Results: The total effective rate was higher in the observation group than that of the control group. BUN, Scr, iPTH and β2-MG were decreased after treatment in two groups, but the decrease value of observation group was more obvious. BDNF and NPY were increased after treatment in two groups, but the increased value of the observation group was more obvious. Conclusion: HD and HP is effect to the treatment of uremic encephalopathy. It has obvious value in clearing uremic toxin and improving therapeutic effect. It can also regulate the content of BDNF and NPY, Should be used actively in clinical treatment.

参考文献/References:

[1] Wang HY,Li Z,An LH. Analysis on risk factors of uremic encephalopathy[J]. J Apo Nervous Dis, 2010, 27(10):935-937.
[2] Ng T, Lee YY, Chae JW, et al. Evaluation of plasma brain-derived neurotrophic factor levels and self-perceived cognitive impairment post-chemotherapy: a longitudinal study[J]. BMC Cancer, 2017, 17(1): 867-868.
[3] Cowley MA, Pronchuk N, Fan W, et al. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus : evidence of a cellular basis for the adipostat[J]. Neuron, 1999, 24(1):155-163.
[4] 陈 婷, 冯永民, 李海坚. 血液灌流联合血液透析治疗尿毒症脑病25例疗效观察[J]. 海南医学院学报, 2011, 17(10):1327-1328.
[5] 张文阁, 唐军亭, 赵慧静,等. 血液灌流联合血液透析治疗尿毒症脑病60例疗效观察[J]. 国际移植与血液净化杂志, 2011, 9(5):44-46.
[6] 李娜娜,李春柳.血液灌流联合血液透析治疗尿毒症脑病的临床观察[J].中国现代药物应用, 2013, 7(19):90-91.
[7] Kim DM,Lee IH, Song CJ. Uremic Encephalopathy: MR imaging findings and clinical correlation[J]. Ajnr American Journal of Neuroradiology, 2016, 37(9):1604-1605.
[8] Im HI, Hollander JA, Bali P, et al. MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212[J]. Nature Neuroscience, 2010, 13(9):1120-1127.
[9] Castren E, Rantamaki T. The role of BDNF and its receptors in depression and antidepressant drug action：Reactivation of developmental plasticity[J]. Developmental Neurobiology,2010, 70(5):289-297.
[10] Rasmusson AM,Hauger RL,Iii C,et al.Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD[J]. Biol Psychiatry, 2000, 47(6):526-539.
[11] Lin S, Boey D, Herzog H. NPY and Y receptors: lessons from transgenic and knockout models[J]. Neuropeptides, 2004, 38(4):189-200.
[12] Ando T, Araki A, Terao S, et al. Bilateral internal capsule lesions in uremic encephalopathy[J]. Neurology & Clinical Neuroscience, 2016, 4(6):243-243.
[13] 曾 立, 杨 琴. 尿毒症脑病的诊治进展[J]. 现代医药卫生, 2016, 20(3):377-380.
[14] 肖太玲,秦 燕.血液透析联合血液灌流治疗尿毒症脑病的疗效观察与护理[J].北京医学,2016,38(1)：84-85.
[15] Raikou V,Tentolouris N, Kyriaki D, et al. B2-microglobulin, pulse pressure and metabolic alterations in patients on hemodialysis[J]. Artery Research, 2011, 5(4):195-195.
[16] Bien E, Rapala M, Krawczyk M, et al. The serum levels of soluble interleukin-2 receptor alpha and lactate dehydrogenase but not of B2-microglobulin correlate with selected clinico-pathological prognostic factors and response to therapy in childhood soft tissue sarcomas[J]. J Cancer Res Clin Oncol, 2010, 136(2):293-305.
[17] 谢 利, 梁静涛, 田嵘臻,等. 参麦注射液对脑缺血大鼠BDNF mRNA和Nogo-A mRNA表达的影响[J]. 陕西中医, 2010, 31(1):121-123.
[18] 姜秀云, 杨 帆, 岳贝贝,等. 中西医结合对急性脑梗死患者疗效及血清MCP-1、BDNF水平的影响[J]. 陕西中医, 2017, 38(4):423-424.
[19] 宁晓霞, 师社会, 邢 亮,等. BDNF、TrkB在大鼠海马CA_3区的表达及其与学习记忆的关系[J]. 陕西医学杂志, 2008, 37(9):1130-1132.

相似文献/References:

[1]徐 博,苏军涛,钟 烨,等.外源性Apelin13对重症急性胰腺炎大鼠治疗作用及其机制研究*[J].陕西医学杂志,2019,(2):148.
　XU Bo,SU Juntao,ZHONG Ye,et al.Effect and mechanism of exogenous apelin13 on severe acute pancreatitis in rats[J].,2019,(8):148.
[2]陈保春,刘利峰.铥激光与等离子电切术治疗膀胱癌疗效对比研究*[J].陕西医学杂志,2019,(2):159.
　CHEN Baochun,LIU Lifeng..Comparative study of thulium laser and plasma electroresection in resection of bladder tumor[J].,2019,(8):159.
[3]张玉亮,朱 宏,戴洪山△.B超引导经皮经肝胆囊穿刺引流术在胆源性胰腺炎治疗中的临床意义[J].陕西医学杂志,2019,(2):166.
　ZHANG Yuliang,ZHU Hong,DAI Hongshan..Clinical significance of Bmode ultrasound guided percutaneous transhepatic  gallbladder puncture and drainage in the treatment of biliary pancreatitis[J].,2019,(8):166.
[4]徐建庆,买赛虎△,杨喜佳,等.腹腔镜手术治疗复杂性胆囊炎临床疗效研究[J].陕西医学杂志,2019,(2):176.
　XU Jianqing,MAI Saihu,YANG Xijia,et al.Analysis of curative effect in laparoscopic surgery for complicated cholecystitis[J].,2019,(8):176.
[5]刘 侃,杨栓元,刘旭晨,等.PPH术治疗III、IV度痔中长期疗效研究[J].陕西医学杂志,2019,(2):183.
　LIU Kan,YANG Shuanyuan,LIU Xucheng,et al.Curative effect of PPH for III and IV hemorrhoids[J].,2019,(8):183.
[6]石 丹,张会久,周达岸.闭合复位经皮空心螺钉内固定与切开复位内固定治疗踝关节骨折疗效对比研究[J].陕西医学杂志,2019,(2):186.
　SHI Dan,ZHANG Huijiu,ZHOU Daan..Comparison of closed reduction, percutaneous cannulated screw fixation and open reduction  and internal fixation for ankle fractures[J].,2019,(8):186.
[7]肖东波.不保留小关节植骨床PLIF术治疗老年脊柱退行性疾病价值研究*[J].陕西医学杂志,2019,(2):189.
　XIAO Dongbo..The value of nonreserving small arthroplasty bone PLIF for senile spinal degenerative diseases[J].,2019,(8):189.
[8]高清滢,侯洁心△.高频电波刀宫颈电环切除术治疗中重度宫颈柱状上皮异位临床疗效研究[J].陕西医学杂志,2019,(2):223.
　GAO Qingying,HOU Jiexin..Observation on the clinical effect of high frequency electric wave knife cervix electroloop resection in the〖JP〗 〖JP4〗treatment of moderate and severe Cervical columnar epithelium ectopicdiagnosed by pathological examination[J].,2019,(8):223.
[9]宋 婷,罗 莉,贾 菲,等.1540 nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗 凹陷性痤疮瘢痕疗效研究[J].陕西医学杂志,2019,(2):241.
　SONG Ting,LUO Li,JIA Fei,et al.Effiicacy of nonablative 1540nm fractional laser with medical cool patch in the treatment of acne sca[J].,2019,(8):241.
[10]张 彦,陈 龙.胃镜下肾上腺素与凝血酶联合治疗消化性溃疡合并出血疗效研究[J].陕西医学杂志,2019,(2):259.

更新日期/Last Update: 2019-08-13