[1]徐 琳,贾睿博△,宋民喜,等.颗粒蛋白前体与糖尿病肾病关系探讨*[J].陕西医学杂志,2019,(8):1024-1027.
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颗粒蛋白前体与糖尿病肾病关系探讨*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1024-1027
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.018
作者:
徐 琳贾睿博△宋民喜李小燕龚惠红
西安市第四医院(西安710004)
关键词:
2型糖尿病颗粒蛋白前体糖尿病肾病 白细胞介素6 肿瘤坏死因子-α 相关性
分类号:
R587.2
文献标志码:
A
摘要:
摘 要 目的:探讨糖尿病肾病(DN)与颗粒蛋白前体(PGRN)的关系。方法:将134例2型糖尿病患者按照尿蛋白排泄率(UAER)分为三组:单纯糖尿病组(SDM组)48例,早期糖尿病肾病组(EDN组)40例,临床期糖尿病肾病组(CDN组)46例;另外选取正常对照组20例。检测所有研究对象血清PGRN及临床生化指标的水平,分析各组间上述指标的变化。结果:在临床2型糖尿病肾病患者中,血清PGRN水平显著升高。血清PGRN水平与测收缩压(SBP),舒张压(DBP)、体重指数(BMI)、甘油三酯(TG),总胆固醇(TC)、UAER、肌酐(CRE)、白细胞介素6(IL-6)以及肿瘤坏死因子-α(TNF-α)呈正相关、与肾小球滤过率(eGFR)呈负相关。将PGRN作为因变量,以上相关指标作为自变量,进行多元逐步回归分析,最终只有CRE、UAER进入方程。结论:PGRN可能作为一种促炎因子参与了糖尿病肾病的进展。

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目(81170741)
更新日期/Last Update: 2019-08-13