[1]李克峰,王 静△,张建标.全腹膜外腹股沟疝修补网片固定术对腹股沟疝患者慢性疼痛及基质金属蛋白酶水平的影响*[J].陕西医学杂志,2019,(8):1013-1016.
　LI Kefeng,WANG Jing,ZHANG Jianbiao..The effects of total extraperitoneal mesh repair on chronic pain and its effect on metalloproteinases[J].,2019,(8):1013-1016.
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全腹膜外腹股沟疝修补网片固定术对腹股沟疝患者慢性疼痛及基质金属蛋白酶水平的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1013-1016
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
The effects of total extraperitoneal mesh repair on chronic pain and its effect on metalloproteinases
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.015
作者:
李克峰1; 王 静1△; 张建标2
1.陕西省汉中市中心医院（汉中 723000）；2.汉中职业技术学院（汉中 723000）
Author(s):
LI Kefeng; WANG Jing; ZHANG Jianbiao.
Hanzhong Central Hospital of Shaanxi(Hanzhong 723000)
关键词:
腹股沟疝; 外科学; 全腹膜外腹股沟疝修补网片固定术; 慢性疼痛; 基质金属蛋白酶; 生活质量
Keywords:
Key words Inguinal hernia; Surgery; Total extraperitoneal inguinal hernia repair mesh fixation;  Chronic pain;  Metalloproteinases; Quality of life
分类号:
R656.21
文献标志码:
A
摘要:
摘 要 目的：探讨全腹膜外腹股沟疝修补网片对腹股沟疝患者慢性疼痛的影响及对基质金属蛋白酶水平的影响。方法：选择189例腹股沟疝行全腹膜外腹股沟疝修补网片固定患者为研究对象，按照随机数字表法将其分为实验组（94例）和对照组（95例），对照组患者实施传统疝修补术，实验组患者实施全腹膜外腹股沟疝修补网片固定术，对两组患者手术时间、术中出血量、术后下床活动时间进行对比，使用视觉模拟评分（VAS）对两组患者术前、术后5、10 d疼痛度进行对比，对两组患者干预前后的基质金属蛋白酶-2（MMP-2）及MMP-9水平进行对比，最后使用生活评定量表（SF-36）对两组患者术后生活质量进行评分。结果：①实验组患者手术时间、术中出血量及术后下床活动时间明显低于对照组（P<0.05）；②术前两组患者VAS评分对比差异不具有统计学意义（P>0.05），术后5、10 d实验组疼痛度低于对照组（P<0.05）；③干预前两组患者MMP-2及MMP-9水平对比差异不具有统计学意义（P>0.05），干预后实验组MMP-2及MMP-9水平低于对照组（P＜0.05）；④干预后实验组患者SF-36各维度评分均低于对照组（P＜0.05）。结论：全腹膜外腹股沟疝修补网片固定术能够显著缓解腹股沟疝患者术后疼痛度，同时降低其金属蛋白酶水平，提高其术后生活质量。
Abstract:
Abstract Objective: To explore the effect of total extraperitoneal inguinal hernia repair mesh on patients with chronic pain and its effect on patients' metalloproteinases.Methods: A total of 189 patients with inguinal hernia were divided into experiments according to the random number table method. In the group (94 cases) and control group (95 cases), patients in the control group underwent conventional hernia repair. Patients in the experimental group underwent complete extraperitoneal inguinal hernia repair and mesh fixation. The operation time, intraoperative blood loss, and postoperative time were both performed on the two groups. Ambulation activity time was compared. Visual analog scale (VAS) was used to compare preoperative and postoperative 5 days and 10 days postoperative pain and foreign body sensation in patients after surgery. Metalloproteinase-2 (MMP-2) before and after intervention in both groups was compared MMP-2 and MMP-9 levels were compared. Finally, the quality of life of the two groups was scored using the Life Assessment Scale (SF-36).Results: ①The time of operation, the amount of bleeding and the time after the operation were significantly lower than that of the control group (P＜0.05)；② there was no statistical difference between the two groups before the operation (P>0.05), and the pain degree in the 5,10 d group was lower than that of the control group (P＜0.05) after the operation (P＜0.05); ③the two groups before the intervention. The contrast difference between MMP-2 and MMP-9 did not have statistical significance (P>0.05), and the level of MMP-2 and MMP-9 in the experimental group was lower than that of the control group (P＜0.05); ④the scores of SF-36 dimensions in the experimental group were lower than those of the control group (P＜0.05).Conclusion: 〖LM〗The total extraperitoneal inguinal hernia repair mesh fixation can significantly relieve pain in patients with inguinal hernia, and at the same time reduce the level of metalloproteinases and improve their postoperative quality of life.

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备注/Memo

备注/Memo:
*陕西省科学技术研究发展计划项目(2011KJXX26)
更新日期/Last Update: 2019-08-13