[1]王 军,欧 理△,周清梓,等.直肠癌患者术后血清补体C3、C4水平变化及其与术后疼痛的相关性研究*[J].陕西医学杂志,2019,(8):984-986，996.
　WANG Jun,OU Li,ZHOU Qingzi,et al.Changes of serum complement C3 and C4 in patients with rectal cancer after operation and their relationship with postoperative pain[J].,2019,(8):984-986，996.
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直肠癌患者术后血清补体C3、C4水平变化及其与术后疼痛的相关性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
984-986，996
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Changes of serum complement C3 and C4 in patients with rectal cancer after operation and their relationship with postoperative pain
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.006
作者:
王 军1; 欧 理1△; 周清梓1; 赵亚宁
1.陕西中医药大学第二附属医院麻醉科（咸阳 712000）；2.陕西中医药大学第二附属医院产科（咸阳 712000）
Author(s):
WANG Jun; OU Li; ZHOU Qingzi; et al.
Department of Anaesthesiology,  The Second Affiliated Hospital of Shaanxi University of Chinese Medicine(Xianyang 712000)
关键词:
直肠癌;  术后疼痛; 补体C3; 补体C4; 视觉模拟评分; 相关性
Keywords:
Key words Rectal cancer; Postoperative pain;  Complement C3; Complement C4; Visual analogue scale score; Relevance
分类号:
R735.37
文献标志码:
A
摘要:
摘 要 目的：探讨血清补体C3、C4水平在直肠癌术后患者中的变化及其与术后疼痛的关系。方法：选取择期行直肠癌根治术的患者45例，分别在术前、术后3、7、12、24、48、72 h检测血清补体C3、C4水平，并使用VAS量表对患者疼痛程度进行评估。结果：术后3～72 h血清补体C3、C4水平呈先上升、后下降的趋势，C3、C4水平在术后3、7、12、24 h高于术前（P＜0.05），C3、C4水平均在术后12 h达到最大值，术后48~72 h与术前比较，差异无统计学意义（P＞0.05）。术后3、7、12、24、48 h和72 h VAS评分呈先上升、后下降的趋势，术后12 h VAS评分达到最大值，随后逐渐下降，术后3、7、12、24 、48 h VAS评分与术前比较差异有统计学意义（P＜0.05），术后72 h VAS 评分与术前比较差异无统计学意义（P＞0.05），血清补体C3、C4水平变化与VAS评分均呈正相关（P＜0.05）。结论：术后疼痛是外科手术引起机体应激反应的一种外在表现，这种应激反应能明显抑制机体的免疫反应，而补体系统与机体免疫息息相关，手术引起的组织损伤性疼痛可引起补体激活，反过来，补体激活又可加重疼痛程度，所以有必要使用镇痛药物进行干预，以减轻术后疼痛，减少补体的释放，有利于促进患者更快康复。
Abstract:
Abstract Objective:To study the correlation between serum levels of complement C3,C4 and postoperative pain in rectal cancer.Methods:45 patients with rectal cancer undergoing radical resection were selected,and the serum levels of complement C3 and C4 were measured and VAS pain level assessed of preoperative and postoperative 3,7,12,24,48,72 h.Results:The levels of complement serum C3 and C4 were firstly increased and then decreased,and compared with preoperative, there were statistically significant of postoperative 3～24 h (P<0.05), C3 and C4 levels reached a maximum at 12 h after surgery, and no statistically significant of postoperative 48～72 h (P＞0.05).VAS scores were firstly increased and then decreased,and compared with preoperative, there were statistically significant of postoperative 3～48 h (P<0.05), and no statistically significant of postoperative 48～72 h (P＞0.05).The serum levels of complement C3 and C4 were positively correlated with VAS score (P<0.05).Conclusion:Postoperative pain is an external manifestation of the body's stress response caused by surgery. This stress response can significantly inhibit the body's immune response, and the complement system is closely related to the body's immune system. The tissue-induced pain caused by surgery can cause complement activation. In turn, complement activation can increase the degree of pain, so it is necessary to use analgesic drugs to reduce postoperative pain, reduce the release of complement, and help promote faster recovery. In the future, the peripheral and central mechanisms of postoperative pain should be further clarified to promote the development of new high-performance drugs.

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备注/Memo

备注/Memo:
*陕西省中医药管理局科研项目（LCMS016)
更新日期/Last Update: 2019-08-13