[1]石颖鹏,王敏娟,李程亮.肠化生相关分子与胃癌的发生和进展研究概况[J].陕西医学杂志,2019,(7):958-封3.
　SHI Yingpeng,WANG Minjuan,LI Chengliang,et al.Intestinal metaplasia-related molecules and the occurrence and progress of gastric cancer[J].,2019,(7):958-封3.
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肠化生相关分子与胃癌的发生和进展研究概况
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年7期
页码:
958-封3
栏目:
综述
出版日期:
2019-07-05

文章信息/Info

Title:
Intestinal metaplasia-related molecules and the occurrence and progress of gastric cancer
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.07.042
作者:
石颖鹏; 王敏娟; 李程亮
西安医学院第一附属医院全科医学科（西安710077)
Author(s):
SHI Yingpeng; WANG Minjuan; LI Chengliang; et al.
Department of General Practice Medicine，The First Affiliated Hospital of Xi’an Medical University(Xi’an 710077)
关键词:
肠化生; 胃黏膜; 胃癌; 分子; 发生; 进展
Keywords:
Key words Intestinal metaplasia; Gastrie mucosa; Gastric cancer; Molecular; Occur; Progress
分类号:
R735.2
文献标志码:
A
摘要:
摘 要 目前胃癌（GC）的发病机制尚未十分明确,Lauren分型将胃癌按照组织病理学分型分为弥漫型胃癌、肠型胃癌以及混合型胃癌,其中肠型胃癌与胃黏膜肠上皮化生（GIM）密切相关，尽管胃黏膜肠上皮化生中只有少数肠化生患者最终发展为肠型胃腺癌，但肠型胃癌仍是最常见的胃癌形式。近年来，从胃肠化生进展到肠型胃腺癌的相关分子机制已被广泛研究。经研究分析发现从肠化生进展到胃癌，其过程与MYC、GOLPH3、HER2、TP53、FBXW7、ARID1A、hTERT、端粒、DNA甲基化、CD24、AQP3、LGR5、Ki67、SOX2、CDX2等分子因素密切相关，临床试验通过大量前瞻性对照研究等试验监测患者从胃肠化生进展到胃癌过程中其相关分子的改变，从而探究胃癌发生的分子基因学机制。本文将对从胃肠化生到胃癌以及胃癌进展过程中的相关分子变化做简要阐述，通过探讨胃癌的发生、转归，进而对早期胃癌的诊断及预防提供有效价值。
Abstract:
Abstract The pathogenesis of gastric cancer (GC) is still not clear. Lauren classification is used to divide gastric cancer into three types: diffuse type gastric cancer，intestinal type gastric cancer and mixed type gastric cancer according to histopathological classification. And the intestinal type gastric cancer is closely correlate with gastric mucosa intestinal metaplasia (GIM). Although only a small number of intestinal metaplasia patients eventually develop into intestinal type gastric adenocarcinoma，intestinal type gastric cancer is still the most common form of gastric cancer. In recent years，the molecular mechanisms involved in the progression from gastrointestinal metaplasia to intestinal gastric adenocarcinoma have been studied extensively. Studies have shown that this transformation is closely related to molecular factors such as MYC，GOLPH3，HER2，TP53，FBXW7，ARID1A，hTERT，Telomere，DNA methylation，CD24，AQP3，LGR5，Ki67，SOX2，CDX2. Besides that，the molecular changes were monitored by numerous prospective controlled studies in patients from gastrointestinal metaplasia to gastric cancer，which were used to explore the molecular genetic mechanism of gastric cancer. This article will briefly review the molecular genetic changes which appear in the process of transformation from gastrointestinal metaplasia to gastric cancer. These changes are helpful to further understand the genesis and development of gastric cancer，and have effective value in the diagnosis of early gastric cancer and prevention of gastric cancer.

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更新日期/Last Update: 2019-07-12