[1]李竹林,赵 瑛.高强度间歇性运动联合药物治疗溃疡性结肠炎疗效及对患者细胞因子水平影响研究*[J].陕西医学杂志,2019,(7):909-912.
　LI Zhulin,ZHAO Ying..Therapeutic effect of high-intensity intermittent exercise combined with drugs on ulcerative colitis and its effect on cytokine levels in patients[J].,2019,(7):909-912.
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高强度间歇性运动联合药物治疗溃疡性结肠炎疗效及对患者细胞因子水平影响研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年7期
页码:
909-912
栏目:
临床研究
出版日期:
2019-07-05

文章信息/Info

Title:
Therapeutic effect of high-intensity intermittent exercise combined with drugs on ulcerative colitis and its effect on cytokine levels in patients
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.07.027
作者:
李竹林1; 赵 瑛
1.陕西省宝鸡市中心医院消化内科 （宝鸡 721008）；2.西安医学院附属宝鸡医院消化内科（宝鸡721006）
Author(s):
LI Zhulin; ZHAO Ying.
Department of Gastroenterology,Baoji Central Hospita(Baoji 721008)
关键词:
溃疡性结肠炎; 英夫利昔单抗; 高强度间歇性运动; 促炎因子; 免疫功能; 影响
Keywords:
Key words Ulcerative colitis; Infliximab; High intensity intermittent exercise; Proinflammatory factor; Immunity; Influence
分类号:
R516.1
文献标志码:
A
摘要:
摘 要 目的：探讨高强度间歇性运动联合药物治疗溃疡性结肠炎（UC）的临床效果及运动对患者血清促炎因子、免疫功能指标的影响。方法：按照随机抽取方式将符合标准的104例UC患者均分为两组。对照组则单纯接受药物治疗；观察组则在用药治疗的同时进行规律性的高强度间歇性运动干预。对比两组临床治疗效果。测定两组治疗前后促炎因子-α（TNF-α、IL-1β、IL-6）和免疫功能指标水平（Th1、Th2、CD3+、CD4+、CD8+、IgA、IgG、补体C3和C4）。结果：经Kruskal Wallis检验分析，轻度、中度、重度患者临床治疗效果间比较差异均具有统计学意义（均P＜0.05）；经Mann-Whitney检验分析，两组轻度、中度患者临床治疗效果和总效果间比较差异存在统计学意义（均P＜0.05），观察组显著优于对照组；但两组重度患者临床疗效间比较差异无统计学意义（P＞0.05）。治疗后，两组促炎因子肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）水平和细胞免疫指标Th1、Th2、CD8+、补体C3、C4水平均明显下降，CD3+百分比、CD4+/CD8+值及IgA、IgG水平均明显升高，且观察组各因子水平明显优于对照组（P＜0.05）。结论：高强度间歇性运动联合药物治疗UC可获得更好的临床治疗效果，尤其是对轻中度患者病情治疗效果更佳，这可能与其下调机体炎症因子表达、调节机体免疫平衡、增强免疫力等作用有关。
Abstract:
Abstract Objective:To explore the clinical effect of high-intensity intermittent exercise combined with drugs in the treatment of ulcerative colitis (UC) and the effect of exercise on serum proinflammatory factors and immune function indicators.Methods:104 patients with UC who met the criteria were divided into two groups by a completely randomized method.The control group was treated with drugsalone；the observation group performed regular high-intensity intermittent exercise intervention on the basis of medication.The clinical effects was compared between the two groups. The levels of pro-inflammatory factors (TNF-α，IL-1β，IL-6) and immune function (Th1，Th2，CD3+，CD4+，CD8+，IgA，IgG，complement C3 and C4) were measured before and after treatment.Results:According to Kruskal Wallis test，the differences in clinical treatment between mild，moderate and severe patients were statistically significant (P＜0.05).According to the Mann-Whitney test，the difference between the clinical treatment effect and the total effect of the mild and moderate patients was statistically significant (P＜0.05),that of the observation group was significantly better than the control group.However，there was no significant difference in clinical efficacy between the two groups (P＞0.05).After treatment，the levels of pro-inflammatory factors TNF-α，IL-1β，IL-6 and cellular immune indicators Th1，Th2，CD8+，complement C3，C4 decreased significantly，andthe level CD3+ percentage，CD4+/CD8+ value and IgA，IgG significantly increased，and the levels of each factor in the observation group were significantly better than those in the control group (P＜0.05).Conclusion:High-intensity intermittent exercise combined with drug therapy for UC can achieve better clinical treatment effect，especially for patients with mild to moderate disease，which may be related to the down-regulation of inflammatory cytokine expression，regulation of immune balance，and enhancement of immunity.

参考文献/References:

[1] 张红金，刘 娇，朱浩刚,等. 小剂量糖皮质激素对重症患者糖皮质激素受体及细胞免疫功能的影响[J]. 中华创伤杂志，2012，28(10):894-896. [2] Higgins PDR，Skup M，Mulani PM，et al. Increased risk of venous thromboembolic events with corticosteroid vs biologic therapy for inflammatory bowel disease[J]. Clinical Gastroenterology & Hepatology the Official Clinical Practice Journal of the American Gastroenterological Association，2015，13(2):316-321. [3] Murthy SK，Nguyen GC . Increasedrisk of venous thromboembolic events with corticosteroid versus biologic therapy for inflammatory bowel disease[J]. Clinical Gastroenterology & Hepatology the Official Clinical Practice Journal of the American Gastroenterological Association，2016，14(1):166-167. [4] Tew GA，Jones K，Mikocka-Walus A . Physicalactivity habits，limitations，and predictors in people with inflammatory bowel disease[J]. Inflammatory Bowel Diseases，2016，22(12):2933-2942. [5] Wang Q，Xu K Q，Qin X R，et al. Association between physical activity and inflammatory bowel disease risk: A meta-analysis[J]. Digestive & Liver Disease Official Journal of the Italian Society of Gastroenterology & the Italian Association for the Study of the Liver，2016，48(12):1425-1431. [6] 中华医学会消化病学分会炎症性肠病协作组. 中国炎症性肠病诊断治疗规范的共识意见[J]. 中华内科杂志，2008，47(1) :73-78. [7] 陈风慧，王晓华，范春梅. 补充外源性维生素D对老年溃疡性结肠炎患者氧化-抗氧化失衡、肠道黏膜屏障和临床预后的影响[J]. 陕西医学杂志，2018，47(12):1634-1637. [8] 肖高健，游旭东，王战波，等. 温中止泻汤对难治型溃疡性结肠炎的疗效及患者血清IL-6、IL-10的水平影响[J]. 陕西中医，2018，39(2):169-171. [9] 晁 康，钟碧慧，张盛洪，等. CD4+T细胞亚群失衡与溃疡性结肠炎发病的关系[J]. 中华医学杂志，2011，91(23) :1605-1608. [10] 吴 昊，夏盛隆，夏宣平,等. 结肠组织中Th1/Th2和Th17细胞失衡与溃疡性结肠炎的关系[J]. 解放军医学杂志，2017，42(9):793-798. [11] 吴铁龙，薛丽莉，戴圆圆,等. 活动期溃疡性结肠炎患者外周血CD4+ CD25+Treg细胞与肠道炎性反应的相关性研究[J]. 国际消化病杂志，2015，35(4):293-294. [12] 王 榕，贾 永，王毓婧,等. 抗肿瘤坏死因子α制剂治疗溃疡性结肠炎的疗效和安全性的 Meta 分析[J]. 西安交通大学学报：医学版，2015，36(2):249-256. [13] 安祥博，张幼怡，宋 峣. 运动对炎症反应的抑制作用[J]. 中国心血管杂志，2016，21(6):432-437. [14] 王 卉，刘绍生，夏 志，等. 长期有氧运动对代谢综合征大鼠炎症及心肌组织过氧化物酶体增殖物激活受体α表达的影响[J]. 中国康复医学杂志，2017，32(12):1351-1355.

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备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2016JM8142)
更新日期/Last Update: 2019-07-12