[1]李 珣,张祥林.肝动脉化疗栓塞联合恩替卡韦对原发性肝癌治疗效果及对患者血清中恶性肿瘤特异性生长因子的影响[J].陕西医学杂志,2019,(7):873-875.
　LI Xun,ZHANG Xianglin..Efficacy observation and TSGF change in primary hepatocellular carcinoma by TACE and entecavir[J].,2019,(7):873-875.
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肝动脉化疗栓塞联合恩替卡韦对原发性肝癌治疗效果及对患者血清中恶性肿瘤特异性生长因子的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年7期
页码:
873-875
栏目:
临床研究
出版日期:
2019-07-05

文章信息/Info

Title:
Efficacy observation and TSGF change in primary hepatocellular carcinoma by TACE and entecavir
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.07.016
作者:
李 珣; 张祥林
锦州医科大学附属第一医院（锦州121000）
Author(s):
LI Xun; ZHANG Xianglin.
First Affiliated Hospital ofJinzhou Medical University (Jinzhou 121000)
关键词:
肝动脉化疗栓塞; 恩替卡韦; 原发性肝癌; 恶性肿瘤特异性生长因子;  对照研究; 生活质量
Keywords:
Key words TACE;  Entecavir;  Primary hepatocellular carcinoma;  TSGF; Control study;  Life quality
分类号:
R735.7
文献标志码:
A
摘要:
摘 要 目的:探讨肝动脉化疗栓塞（TACE）联合恩替卡韦对原发性肝癌患者的治疗效果，关注其对血清中恶性肿瘤特异性生长因子（TSGF）的调节作用。方法:选择106例原发性肝癌患者，按入院顺序进行编号，依随机的原则分为两组，各53例，对照组单纯应用TACE，观察组应用TACE联合恩替卡韦。于治疗前和治疗3个月后，抽取患者静脉血检测TSGF的水平。应用SF-36量表观察治疗3个月后两组生活质量的差别。结果：观察组的3个月的疗效、1年生存率均明显优于对照组，两组治疗3个月后血清中TSGF均有下降，但是观察组的下降值更明显。观察组治疗3个月后的生活质量（8个维度）评分高于对照组。结论:原发性肝癌患者应用TACE联合恩替卡韦进行治疗，效果较为理想，生活质量较好，对血清中TSGF的表达有下调作用，临床中可以积极应用。
Abstract:
Abstract Objective:To observe effect and TSGF change by TACE combined with entecavir in patients with primary hepatocellular carcinoma，analyze clinical significance. Methods:106 patients were divided into two groups by randomness principle. The control group(53 cases) were treated by TACE，the observation group(53 cases) were treated by TACE combined with entecavir. We observed the efficacy，change of TSGF and life quality（SF-36 scale）different in two groups. Results:The 3-month effect and 1-year survival rate were obviously higher in observation group than in control group. Expression of TSGF was decreased in two groups after 3 months，but decreased value of TSGF was higher in observation group. Life quality scores was higher in observation group than control group. Conclusion：TACE combined with entecavir can improve curative effect，improve life quality，decrease expression of TSGF in patients with primary hepatocellular carcinoma，should be actively used in clinic work.

参考文献/References:

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更新日期/Last Update: 2019-07-12