[1]韩丕华,宋张骏△,杨晓民,等.乳腺超声造影联合细针穿刺定位活检在判定乳腺癌新辅助化疗后腋窝淋巴结性质中的临床研究*[J].陕西医学杂志,2019,(7):842-845.
　HAN Pihua,SONG Zhangjun,YANG Xiaomin,et al.Application of breast contrast-enhanced ultrasonography combined with fine needle aspiration biopsy in determining the axillary lymph node properties after neoadjuvant chemotherapy for breast cancer[J].,2019,(7):842-845.
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乳腺超声造影联合细针穿刺定位活检在判定乳腺癌新辅助化疗后腋窝淋巴结性质中的临床研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年7期
页码:
842-845
栏目:
临床研究
出版日期:
2019-07-05

文章信息/Info

Title:
Application of breast contrast-enhanced ultrasonography combined with fine needle aspiration biopsy in determining the axillary lymph node properties after neoadjuvant chemotherapy for breast cancer
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.07.007
作者:
韩丕华; 宋张骏△;  杨晓民; 王虎霞; 贺 赛;  范拥国; 候艳妮
陕西省肿瘤医院乳腺2科（西安 710061）
Author(s):
HAN Pihua; SONG Zhangjun; YANG Xiaomin; et al.
Galactophore Department of Shaanxi Provincial Cancer Hospital(Xi’an 710061）
关键词:
超声造影; 细针穿刺定位活检; 乳腺癌; 新辅助化疗; 腋窝淋巴结; 诊断价值
Keywords:
Key words Contrast-enhanced ultrasonography; Fine needle aspiration biopsy; Breast cancer; Neoadjuvant chemotherapy; Axillary lymph node; Diagnostic value
分类号:
R737.9
文献标志码:
A
摘要:
摘 要 目的：探究乳腺超声造影联合细针穿刺定位活检在判定乳腺癌新辅助化疗后腋窝淋巴结性质中的应用。方法：收集单侧乳腺癌合并腋窝淋巴结转移患者74例，对两组患者进行超声造影和细针穿刺定位活检。以术后病理诊断结果为金标准，对乳腺超声造影、细针穿刺定位活检以及二者联合的诊断价值进行分析，包括诊断的灵敏度、特异度和准确率，二者联合诊断中，一种方法诊断为阳性，即判定为阳性，二者同时诊断为阴性时，即判定为阴性。 结果：超声造影检查诊断为腋窝淋巴结转移阳性的患者68例，阴性患者6例，诊断灵敏度为88.57%（62/70），特异度为75%（3/4），诊断准确率为87.84%（65/74）。细针穿刺定位活检中，诊断为腋窝淋巴结转移阳性的患者54例，阴性患者15例，诊断灵敏度为77.14%（54/70），特异度为100%（4/4），诊断准确率为82.86%（58/74）。联合检测中，诊断为腋窝淋巴结转移阳性的患者67例，阴性患者6例，诊断灵敏度为95.71%（67/70），特异度为50.00%（2/4），诊断准确率为93.24%（69/74）。三组之间灵敏度和准确率比较，差异有统计学意义（P＜0.05），其中联合检测的灵敏度（95.71%）和准确率（93.24%）最高，且显著高于细针穿刺定位活检的灵敏度和准确率（P＜0.05），三组之间的特异度经比较，差异无统计学意义（P＞0.05）。结论：乳腺癌患者新辅助化疗后腋窝淋巴结性质的诊断中，乳腺超声造影和细针穿刺定位活检联合应用能够提高诊断的灵敏度和准确率。
Abstract:
Abstract Objective: To study the application of breast contrast-enhanced ultrasonography combined with fine needle aspiration biopsy in determining the axillary lymph node properties after neoadjuvant chemotherapy for breast cancer. Methods: 74 patients with unilateral breast cancer and axillary lymph node metastasis who underwent treatment from June 2016 to September 1818 were enrolled in the hospital. Ultrasonography and fine needle biopsy were performed on the two groups. The postoperative pathological diagnosis was the gold standard，and the diagnostic value of breast ultrasound contrast，fine needle aspiration biopsy and the combination of the two were analyzed，including the sensitivity，specificity and accuracy of the diagnosis. In the combined diagnosis of the two，one method is diagnosed as positive，it is judged to be positive，and when both are diagnosed as negative，it was judged to be negative. Results: Contrast-enhanced ultrasonography was performed in 68 patients with positive axillary lymph node metastasis and 6 patients with negative diagnosis. The diagnostic sensitivity was 88.57% (62/70)，the specificity was 75% (3/4)，and the diagnostic accuracy was 87.84% (65/74). In the fine needle aspiration biopsy，54 patients with positive axillary lymph node metastasis were diagnosed，and 15 patients were negative. The diagnostic sensitivity was 77.14% (54/70)，the specificity was 100% (4/4)，and the diagnostic accuracy was 82.86. %(58/74). In the combined test，67 patients were diagnosed as axillary lymph node metastasis，and 6 patients were negative. The diagnostic sensitivity was 95.71% (67/70)，the specificity was 50.00% (2/4)，and the diagnostic accuracy was 93.24%〖LM〗 (69/74). The sensitivity and accuracy of the three groups were significantly different (P＜0.05)，and the sensitivity (95.71%)and accuracy (93.24%) of the combined detection were the highest，and significantly higher than the sensitivity and accuracy of the fine needle biopsy(P＜0.05)，the specificity between the three groups was compared，the difference was not statistically significant (P＞0.05). Conclusion: In the diagnosis of axillary lymph node properties after neoadjuvant chemotherapy in breast cancer patients，the combination of breast ultrasound contrast and fine needle aspiration biopsy can improve the sensitivity and accuracy of diagnosis.

参考文献/References:

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备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2014D4)
更新日期/Last Update: 2019-07-12