[1]米志宽,赵菊梅.抑癌基因甲基化与胃癌关系研究进展*[J].陕西医学杂志,2019,(5):679-封3.
　MI Zhikuan,ZHAO Jumei..Research progress of relationships between tumor suppressor gene methylation and gastric cancer[J].,2019,(5):679-封3.
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抑癌基因甲基化与胃癌关系研究进展*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年5期
页码:
679-封3
栏目:
综述
出版日期:
2019-05-05

文章信息/Info

Title:
Research progress of relationships between tumor suppressor gene methylation and gastric cancer
文章编号:
DOI: 10.3969/j.issn.10007377.2019.05.038
作者:
米志宽; 赵菊梅
延安大学医学院（延安 716000）
Author(s):
MI Zhikuan;  ZHAO Jumei.
Yan’an University Medical College（Yan’an 716000）
关键词:
胃癌; 抑癌基因; 甲基化; CDH1基因; CDKN2A基因; hMLH1基因
Keywords:
Key words Gastric cancer;  Tumor suppressor gene;  Methylation; CDH1 gene; CDKN2A gene; hMLH1 gene
分类号:
R735
文献标志码:
A
摘要:
摘 要 肿瘤是遗传学和表遗传学共同作用的结果。胃癌表遗传学主要表现为DNA甲基化和组蛋白修饰。几种抑癌基因的甲基化导致其功能缺失，在胃癌的发生发展和转移中起着非常重要的作用，本文对此作了综述。
Abstract:
Abstract Cancer is the results of the interaction of genetics and epigenetics. Gastric cancer epigenetics mainly includes DNA methylation and histone modification. Methylation of several tumor suppressor genes leads to the loss of function and plays a very important role in the development and metastasis of gastric cancer, which is reviewed in this paper.

参考文献/References:

[1] Patel TN,Roy S,Ravi R.Gastric cancer and related epigenetic alterations[J]. Ecancermedicalscience,2017,11：714. [2] Tie J, Zhang X, Fan D. Epigenetic roles in the malignant transformation of gastric mucosal cells[J]. Cell Mol Life Sci,2016,73(24)：4599-4610. [3] Sonohara F, Inokawa Y, Hayashi M,et al. Epigenetic modulation associated with carcinogenesis and prognosis of human gastric cancer[J]. Oncol Lett,2017,13(5):3363-3368. [4] Liu X, Chu KM. Ecadherin and gastric cancer: cause, consequence, and applications[J]. Biomed Res Int,2014,2014:637308. [5] Qu Y, Dang S, Hou P. Gene methylation in gastric cancer[J]. Clin Chim Acta,2013,424:53-65. [6] Jang BG, Kim WH. Molecular pathology of gastric carcinoma[J]. Pathobiology,2011, 78(6):302-310. [7] Zeng W, Zhu J, Shan L,et al. The clinicopathological significance of CDH1 in gastric cancer: a metaanalysis and systematic review[J]. Drug Des Devel Ther,2015,9:2149-2157. [8] Kotake Y, Naemura M, Murasaki C,et al. Transcriptional regulation of the p16 tumor suppressor gene[J]. Anticancer Res,2015,35(8):4397-401. [9] Zhao C, Bu X. Promoter methylation of tumorrelated genes in gastric carcinogenesis[J]. Histol Histopathol,2012,27(10):1271-1282. [10] Otani K, Li X, Arakawa T,et al. Epigeneticmediated tumor suppressor genes as diagnostic or prognostic biomarkers in gastric cancer[J]. Expert Rev Mol Diagn,2013,13(5):445-455. [11] Imai K, Yamamoto H. Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics[J]. Carcinogenesis,2008,29(4):673-680. [12] Arai T, Kasahara I, Sawabe M,et al.Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly[J]. Geriatr Gerontol Int, 2010,10(Suppl 1):S207-S212. [13] Strosberg J,Goldman J,Costa F,et al.The role of chemotherapy in welldifferentiated gastroenteropancreatic neuroendocrine tumors[J]. Front Horm Res,2015,44:239-247. [14] Paska AV, Hudler P. Aberrant methylation patterns in cancer: a clinical view[J]. Biochem Med (Zagreb),2015,25(2):161-176. [15] Joo MK, Kim KH, Park JJ,et al.CpG island promoter hypermethylation of Ras association domain family 1A gene contributes to gastric carcinogenesis[J].Mol Med Rep,2015, 11(4):3039-3046. [16] Shi DT, Han M, Gao N,et al. Association of RASSF1A promoter methylation with gastric cancer risk: a metaanalysis[J]. Tumour Biol,2014,35(2):943-948. [17] Balgkouranidou I, Matthaios D, Karayiannakis A,et al. Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients[J]. Mutat Res,2015,778:46-51. [18] Yang Q, Shao Y, Shi J,et al. Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer[J]. Clin Biochem,2014,47(12):111-116. [19] Liu X, Wang L, Guo Y. The association between runtrelated transcription factor 3 gene promoter methylation and gastric cancer: A metaanalysis[J].J Cancer Res Ther,2016,12(Supplement):50-53. [20] Wang N, Sui F, Ma J,et al. Sitespecific hypermethylation of RUNX3 predicts poor prognosis in gastric cancer[J]. Arch Med Res,2016,47(4):285-292. [21] Lin Z, Luo M, Chen X,et al. Combined detection of plasma ZIC1, HOXD10 and RUNX3 methylation is a promising strategy for early detection of gastric cancer and precancerous lesions[J]. J Cancer,2017,8(6):1038-1044. [22] Wu CS, Wei KL, Chou JL,et al. Aberrant JAK/STAT signaling suppresses TFF1 and TFF2 through epigenetic silencing of GATA6 in gastric cancer[J]. Int J Mol Sci,2016,17(9): E1467. [23] Feng G, Zhang Y, Yuan H,et al. DNA methylation of trefoil factor 1 (TFF1) is associated with the tumorigenesis of gastric carcinoma[J]. Mol Med Rep,2014,9(1):109-117. [24] Tanaka T, Nakamura J, Kitajima Y,et al. Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer[J]. Int J Oncol,2013,42(3):894902. [25] Shiotani A, Cen P, Graham DY. Eradication of gastric cancer is now both possible and practical[J]. Semin Cancer Biol,2013,23(6 Pt B):492-501. [26] Fu Z, Tian H, Wang F,et al. Carcinogenic mechanisms of highrisk human papillomavirus oncoproteins[J]. Int J Clin Exp Med,2016,9(10):20439-20447. [27] Guo M, Yan W. Epigenetics of gastric cancer[J]. Methods Mol Biol, 2015,1238:783-799.

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备注/Memo

备注/Memo:
*陕西省教育厅专项科研计划项目（17JK0867）
更新日期/Last Update: 2019-05-07