[1]赵现立,高文丽,高巧莲,等.不同级别宫颈病变中HRHPV亚型分布研究[J].陕西医学杂志,2019,(5):647-649,653.
　ZHAO Xianli,GAO Wenli,GAO Qiaolian,et al.Distribution of HRHPV subtypes in different grades of cervical lesions with highrisk human papillomavirus infection[J].,2019,(5):647-649,653.
点击复制

不同级别宫颈病变中HRHPV亚型分布研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年5期
页码:
647-649,653
栏目:
临床研究
出版日期:
2019-05-05

文章信息/Info

Title:
Distribution of HRHPV subtypes in different grades of cervical lesions with highrisk human papillomavirus infection
文章编号:
DOI: 10.3969/j.issn.10007377.2019.05.029
作者:
赵现立; 高文丽; 高巧莲; 贺同强
西北妇女儿童医院（西安 710061）
Author(s):
ZHAO Xianli; GAO Wenli; GAO Qiaolian; et al.
Northwest Women and Children’s Hospital（Xi’an 710061）
关键词:
人乳头状瘤病毒; 宫颈低度鳞状上皮内病变; 宫颈高度鳞状上皮内病变; 宫颈鳞状细胞癌; 高危型人乳头瘤病毒; 相关性
Keywords:
Key words Human papillomavirus; Lowgrade squamous intraepithelial lesion; Highgrade squamous intraepithelial lesion; Cervical squamous carcinoma; High risk human papilloma virus; Relevance
分类号:
R711.74
文献标志码:
A
摘要:
摘 要 目的：对不同级别宫颈病变中HRHPV亚型的分布情况进行分析，为宫颈癌的预防提供更精确的数据。方法：对360例不同级别宫颈病变患者，统计分析其HRHPV的亚型感染情况。结果：120例宫颈LSIL的HRHPV感染者为106例，阳性率88.3%。120例宫颈HSIL的HRHPV感染者为113例，阳性率94.2%。120例宫颈鳞状细胞癌Ⅰ期的HRHPV感染者为114例，阳性率95%，三组之间的感染率没有统计学差异（P＞0.05）。在所有患者中，HRHPV各个分型感染率前五位由高到低分别是16、58、52、33、18。结论：宫颈癌的发生与HRHPV密切相关，目前在国内批准和开展的9价HPV疫苗能够预防常见的HRHPV亚型感染。
Abstract:
Abstract Objective：Analysis of the distribution of HRHPV subtypes in different grades of cervical lesions.Methods：The HRHPV subtype infection was statistically analyzed in 360 patients with different grades of cervical lesions.Results:There were 106 cases of HRHPV infection in 120 cases of cervical LSIL,the positive rate was 88.3%.There were 113 cases of HRHPV infection in 120 cases of cervical HSIL, and the positive rate was 94.2%.There were 114 cases of HRHPV infection in 120 cases of cervical squamous cell carcinoma, and the positive rate was 95%.There was no significant difference in the infection rate between the three groups (P＞0.05). In all patients,the top five infection rates of HRHPV were 16,58,52,33,and 18,respectively.Conclusion：The occurrence of cervical cancer is closely related to HRHPV, Cervical cancer vaccines can prevent common HRHPV subtype infections.

参考文献/References:

[1] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J].Ca Cancer J Clin, 2016, 66(2)：115-132. [2] Wilson JP.The lower anogenital squamous terminology standardization project for HPVAssociated Lesions:Background and Consensus Recommendations From the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology: Erratum[J]. Journal of Lower Genital Tract Disease, 2013，17(5589):11-13. [3] 马亚琪, 刘爱军. 宫颈癌及癌前病变病理诊断及研究进展[J]. 实用妇产科杂志, 2015, 31(11):803-805. [4] 邱笑飞, 林 敏, 姚招男, 等. 宫颈上皮内瘤变及宫颈癌Ⅰ期患者高危型人乳头瘤病毒的变化情况[J]. 中华医院感染学杂志, 2017，29(7):168-171. [5] 张忠明, 崔绪琴, 李 娜, 等.宫颈上皮内瘤变及微浸润癌患者人乳头瘤病毒基因亚型分析[J]. 西安交通大学学报：医学版,2016,43：457-460. [6] Sanjose D,Silvia A,Quint T,et al.Human papillomavirus genotype attribution in invasive cervical cancer: aretrospective crosssectional worldwide study[J]. Lancet Oncology, 2010, 11(11):1048-1056. [7] 崔亚杰,张培莲. 宫颈上皮内瘤变中人乳头瘤病毒基因分型及感染状况研究[J]. 陕西医学杂志,2015,44(10)：1308-1309. [8] 赵现立, 高文丽, 胡 彤, 等.宫颈上皮内瘤变合并高危型人乳头瘤病毒感染患者阴道感染研究[J]. 陕西医学杂志, 2018,47(8)：997-999. [9] 张 靖, 高 波, 康 赟, 等.中国女性宫颈人乳头瘤病毒感染型别分布区域性特征的 Meta 分析[J]. 中华微生物学和免疫学杂志, 2014，34(12):913-920. [10] 赵宏喜, 谢 丽, 朱少君, 等. 女性人乳头瘤病毒感染4965例各亚型分布及相关因素分析[J]. 陕西医学杂志,2017,46(9)：1921-1924.

相似文献/References:

[1]周 成,柴艳梅,陈 蓉,等.湖北荆门地区2698例女性HPV感染情况及基因分型调查研究[J].陕西医学杂志,2020,49(11):1523.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.040]
　ZHOU Cheng,CHAI Yanmei,CHEN Rong,et al.Study on human papillomavirus infection and genotyping of 2698 women in Jingmen[J].,2020,49(5):1523.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.040]

更新日期/Last Update: 2019-05-07