[1]姚爱红.利拉鲁肽治疗2型糖尿病效果及对患者血脂、颈动脉内膜中层厚度的影响[J].陕西医学杂志,2019,(4):518-520.
　YAO Aihong..Effect of liraglutide on type 2 diabetes mellitus in patients with blood lipids and carotid intimamedia thickness[J].,2019,(4):518-520.
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利拉鲁肽治疗2型糖尿病效果及对患者血脂、颈动脉内膜中层厚度的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年4期
页码:
518-520
栏目:
药物与临床
出版日期:
2019-04-05

文章信息/Info

Title:
Effect of liraglutide on type 2 diabetes mellitus in patients with blood lipids and carotid intimamedia thickness
文章编号:
DOI: 10.3969/j.issn.10007377.2019.04.032
作者:
姚爱红
上海市金山区漕泾社区卫生服务中心(上海 201507)
Author(s):
YAO Aihong.
Shanghai Jinshan District Community Health Service Center (Shanghai 201507)
关键词:
2型糖尿病; 利拉鲁肽; 血脂; 颈动脉内膜中层厚度; 动脉粥样硬; 对比研究
Keywords:
Key words Type 2 diabetes;  Liraglutide;  Blood lipids;  Carotid intimamedia thickness;  Atherosclerosis; Comparative study〖HJ1〗
分类号:
R587.1
文献标志码:
A
摘要:
摘 要 目的：探究利拉鲁肽治疗2型糖尿病对患者血脂及颈动脉内膜中层厚度的影响。方法：研究对象选取166例2型糖尿病患者，采用数字表法随机分为观察组和对照组各83例，对照组采用二甲双胍联合卡托普利治疗，观察组则在对照组基础上加用利拉鲁肽治疗，两组患者均连续用药3个月，对比两组患者治疗前后的血糖控制情况，并统计对比两组患者的血脂及颈动脉内膜中层厚度（IMT）情况。结果：治疗前两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白水平对比差异均无统计学意义（P＞0.05），治疗后观察组改善程度均显著优于对照组，差异具有统计学意义（P＜0.05）；两组患者治疗前的总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、IMT对比差异无统计学意义（P＞0.05），治疗后观察组各项指标均明显改善，与对照组相比差异具有统计学意义（P＜0.05）；观察组不良反应发生率10.8%，对照组不良反应发生率9.6%，两组对比差异无统计学差异（P＞0.05）。结论：利拉鲁肽治疗2型糖尿病能够更有效的控制患者的血糖水平，并具有调节血脂和改善颈动脉内膜中层厚度的作用，可有效减轻2型糖尿病患者的动脉粥样硬化进程。
Abstract:
Abstract Objective: To investigate the effect of liraglutide on type 2 diabetes mellitus in patients with blood lipids and carotid intimamedia thickness. Methods: A total of 166 patients with type 2 diabetes mellitus were randomly divided into observation group and control group by 83 patients. The control group was treated with metformin. Topira treatment, the observation group was treated with liraglutide on the basis of the control group, the two groups of patients were treated for 3 months, the blood glucose control before and after treatment was compared between the two groups, and the blood lipids of the two groups were compared statistically. And carotid intimamedia thickness (IMT). Renults: There were no significant differences in fasting blood glucose, postprandial 2 h blood glucose, and glycosylated hemoglobin levels between the two groups before treatment (P>0.05). The improvement in the observation group was significantly better than that in the control group after treatment. The difference was statistically significant (P<0.05); There was no significant difference in total cholesterol, triglyceride, lowdensity lipoprotein cholesterol, highdensity lipoprotein cholesterol and IMT between the two groups (P>0.05). After treatment, the indicators in the observation group were obvious. Compared with the control group, the difference was statistically significant (P<0.05); the incidence of adverse reactions in the observation group was 10.8%, and the incidence of adverse reactions in the control group was 9.6%. There was no significant difference between the two groups (P>0.05). Conclusion: Liraglutide can effectively control the blood glucose level of patients with type 2 diabetes, and can regulate blood lipids and improve the thickness of carotid intimamedia. It can effectively alleviate the atherosclerosis process in patients with type 2 diabetes.

参考文献/References:

[1] 傅晓莹，杨华章，邝 建，等. 利拉鲁肽治疗2 型糖尿病的疗效及安全性[J]. 广东医学，2013，34 (23):3651-3653.
[2] 陈一丁，姚伟峰，万 惠，等. 2 型糖尿病合并非酒精性脂肪性肝病的相关影响因素及其与颈动脉粥样硬化的关系研究[J]. 中国全科医学，2013，16 (35):4131-4134.
[3] 中华医学会糖尿病学分会. 中国2 型糖尿病防治指南(2013 年版) [J]. 中华内分泌代谢杂志，2014，30(10):893-942.
[4] 刘 莉，李阳春，游 凌，等. 糖尿病心血管事件危险因素的临床研究[J]. 中西医结合心脑血管病杂志，2011，9(11):1313-1314.
[5] Hong SL, Myeong-HY, Seung JT, et al. Usefulness of the index of microcirculatory resistance for invasively assessing myocardial viability immediately after primary angioplasty for anterior myocardial infarction[J]. European Heart Journal, 2015, 36(23):2854.
[6] Selvin E, Crainiceanu CM, Brancati FL, et al. Short-term variability in measures of glycemia and implications for the classification of diabetes[J]. Archives of Internal Medicine, 2017, 177(14):1545-1551.
[7] Gustavsson CG, Agardh CD. Markers of inflammation in patients with coronary artery disease are also associated with glycosylated haemoglobin A1c within the normal range[J]. Eur Heart J, 2015, 35(23):2120-2124.
[8] 隋 辉，陈伟伟，王 文.《中国心血管病报告2015》要点解读[J]. 中国心血管杂志，2016，21(4):259-261.
[9] 陈群峰，王永祥. 利拉鲁肽临床研究进展[J]. 世界临床药物，2013，34(5):312-315.
[10] 杜习智，李全忠. 利拉鲁肽治疗2 型糖尿病的疗效及安全性[J]. 医药论坛杂志，2015，36(10):152-153.

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更新日期/Last Update: 2019-04-10