[1]史 璇,张 鑫,朱金朋,等.结直肠腺癌组织中CYR61和血管内皮生长因子的表达及相关性研究*[J].陕西医学杂志,2019,(4):421-423.
　SHI Xuan,ZHANG Xin,ZHU Jinpeng,et al.Expressions and relationship of CYR61 and VEGF in colorectal adenocarcinoma[J].,2019,(4):421-423.
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结直肠腺癌组织中CYR61和血管内皮生长因子的表达及相关性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年4期
页码:
421-423
栏目:
基础研究
出版日期:
2019-04-05

文章信息/Info

Title:
Expressions and relationship of CYR61 and VEGF in colorectal adenocarcinoma
文章编号:
DOI: 10.3969/j.issn.10007377.2019.04.003
作者:
史 璇; 张 鑫; 朱金朋; 邸 巍; 田 蕾
锦州医科大学附属第一医院消化内科三病区（ 锦州 121000）
Author(s):
SHI Xuan;  ZHANG Xin;  ZHU Jinpeng;  et al.
Three wards of Digestive Medicine, First Affiliated Hospital of Jinzhou Medical University, City Liaoning Province(Jinzhou 121000)
关键词:
结直肠; 腺癌; 高半胱氨酸蛋白61; 血管内皮生长因子; 临床病理; 相关性
Keywords:
Key words Colorectal; Adenocarcinoma; Homocysteine protein 61; Vascular endothelial growth factor; Clinical pathology; Correlation
分类号:
R735.3
文献标志码:
A
摘要:
摘 要 目的：检测结直肠腺癌中高半胱氨酸蛋白61（CYR61）和血管内皮生长因子（VEGF）的表达，分析两者在不同临床病理特征中的表达差别及相关性。 方法：选择77例结直肠腺癌患者及术后的新鲜组织作为观察组，选择正常结肠黏膜新鲜组织12例作为对照组，应用流式细胞术检测两组中CYR61和VEGF的表达。 结果：两组中CYR61和VEGF的表达量差别有统计学意义，观察组中CYR61和VEGF的表达与肿瘤的最大径、肿瘤的浸润深度密切相关，CYR61与肿瘤的分化程度和增殖指数密切相关，VEGF的表达与肿瘤的淋巴结转移密切相关。相关性分析显示观察组中CYR61和VEGF的表达具有正相关性。 结论：结直肠腺癌组织中CYR61和VEGF高表达对促进肿瘤性病变的形成和进展有重要作用。CYR61和VEGF之间具有正向协同作用。
Abstract:
Abstract Objective:To detect the expressions of CYR61 and VEGF in colorectal adenocarcinoma, and to analyze the difference and correlation in different clinicopathological features. Methods :77 patients with colorectal adenocarcinoma(fresh tissue) were selected as the observation group. 12 normal colonic mucosa fresh tissues were selected as the observation group. CYR61 and VEGF were detected by FCM in two groups. Results：Expressions of CYR61 and VEGF were significantly different between two groups. Expressions of CYR61 and VEGF were closely related to maximum diameter and invasive depth in observation group. CYR61 was closely related to differentiation and proliferation index. VEGF was closely related to lymph node metastasis. CYR61 and VEGF was positively correlated in the observation group. Conclusion: Higher expressions of CYR61 and VEGF can promote formation and progression in colorectal adenocarcinoma. There is a positive synergistic effect between CYR61 and VEGF.

参考文献/References:

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备注/Memo

备注/Memo:
*辽宁省科学技术厅科研项目（2015020329）
更新日期/Last Update: 2019-04-10