[1]王改华,孙红艳.小剂量阿司匹林肠溶片对改善妊高症高危患者127例凝血功能临床价值研究[J].陕西医学杂志,2019,(3):389-392.
　WANG Gaihua,SUN Hongyan..Clinical effect of low dose Aspirin Entericcoated Tablets in improving coagulation functionin 127 patients with high risk of pregnancy induced hypertension[J].,2019,(3):389-392.
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小剂量阿司匹林肠溶片对改善妊高症高危患者127例凝血功能临床价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年3期
页码:
389-392
栏目:
药物与临床
出版日期:
2019-03-05

文章信息/Info

Title:
Clinical effect of low dose Aspirin Entericcoated Tablets in improving coagulation functionin 127 patients with high risk of pregnancy induced hypertension
文章编号:
DOI:10.3969/j.issn.10007377.2019.03.029
作者:
王改华; 孙红艳
西安市第四医院妇产科（西安 710004）
Author(s):
WANG Gaihua; SUN Hongyan.
Department of Gynecology,Xi’an No.4 Hospital(Xi’an 710004)
关键词:
阿司匹林肠溶片; 小剂量; 妊高症; 凝血功能; 安慰剂
Keywords:
Key words 〖JP4〗Aspirin Entericcoated Tablets;  Low dose;  Pregnancy induced hypertension;  Coagulation function;  Placebo
分类号:
R714.2
文献标志码:
A
摘要:
摘 要 目的:探讨小剂量阿司匹林肠溶片对改善妊高症高危（PIH）患者凝血功能的临床价值。方法:采用随机数字法将127例PIH患者随机分为观察组（n=64）和对照组（n=63）。对照组给予安慰剂治疗，观察组给予阿司匹林肠溶片治疗。观察比较两组治疗前后凝血指标PT、APTT、TT、FIB、DD变化，记录两组妊高症及不良反应发生情况。结果：观察组妊高症发病12例，发病率为18.75%，明显低于对照组的25例（39.68%），两组比较差异有统计学意义（χ2=6.738，P＜0.05）。治疗前，观察组和对照组患者凝血功能指标PT、APTT、TT、FIB、DD水平比较差异无统计学意义（P＞0.05）。治疗后，对照组上述凝血功能指标水平未出现明显变化（P＞0.05）；观察组PT、APTT、TT明显延长，FIB、DD含量明显下降，治疗前后比较差异具有统计学意义（P＜0.01）；且与对照组比，观察组治疗后PT、APTT、TT明显延长，FIB、DD含量明显升高，组间比较差异有统计学意义（P＜0.05）。观察组患者发生消化不良、胃痛及牙龈出血等不良反应7例，〖JP2〗不良反应发生率10.94%，对照组发生此类不良反应5例，不良反应发生率7.94%，两组患者在治疗过程中的不良反应比较无统计学差异（χ2=0.334，P＞0.05）。结论: 小剂量阿司匹林肠溶片预防PIH临床疗效显著，可有效降低妊高症的发生概率，改善高危患者凝血功能状态，且具有较高安全性。
Abstract:
Abstract Objective: This study aims to investigate the clinical value of lowdose aspirin entericcoated tablets in improving the coagulation function in patients with pregnancy induced hypertension (PIH). Methods: 127 patients with PIH were randomly assigned to observation group (n=64) and control group (n=63).The control group was given placebo treatment, while the observation group was treated with lowdose Aspirin Entericcoated tablets. The changes of coagulation parameters PT, APTT, TT, FIB and DD before and after treatment were observed and compared. The incidence of pregnancyinduced hypertension and adverse reactions was recorded. Results: The incidence of PIH in the observation group of 12 cases (18.75%) was statistically significantly lower than that of 25 cases (39.68%) in the control group (χ2=6.738, P＜0.05). Before treatment, there was no significant difference in the levels of clotting function indicators PT, APTT, TT, FIB and DD between the observation group and the control group (P＞0.05). After treatment, there was no significant change in the level of coagulation function in the control group (P＞0.05). The PT, APTT and TT in the observation group were significantly prolonged, and the contents of FIB and DD were significantly decreased,and the difference between the two groups was statistically significant (P＜0.01). Compared with the control group, PT, APTT and TT were significantly prolonged in the observation group, and the levels of FIB and DD were significantly increased,and the difference between the groups was statistically significant (P＜0.05). There were 7 cases (10.94%) of adverse reactions such as dyspepsia, stomachache and gingival bleeding in the observation group, however 5 cases (10.94%) in the control group, which there was no significant difference between the two groups (χ2=0.334, P＞0.05). Conclusion: Lowdose aspirin entericcoated tablets have significant clinical efficacy in preventing PIH, which can effectively reduce the incidence of pregnancyinduced hypertension, improve the coagulation function of highrisk patients, and has high safety.

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更新日期/Last Update: 2019-03-15