[1]于庆伟,秦彦昌,张百平,等.长链非编码RNA AFAP1AS1在神经胶质瘤中表达水平及影响预后的相关因素研究[J].陕西医学杂志,2019,(3):297-300.
　YU Qingwei,QIN Yanchang,ZHANG Baiping,et al.The expression level of long noncoding RNA AFAP1AS1 in glioma and the study about the related factors of prognosis[J].,2019,(3):297-300.
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长链非编码RNA AFAP1AS1在神经胶质瘤中表达水平及影响预后的相关因素研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年3期
页码:
297-300
栏目:
基础研究
出版日期:
2019-03-05

文章信息/Info

Title:
The expression level of long noncoding RNA AFAP1AS1 in glioma and the study about the related factors of prognosis
文章编号:
DOI:10.3969/j.issn.10007377.2019.03.004
作者:
于庆伟; 秦彦昌; 张百平; 罗国强
空军军医大学第二附属医院神经外科(西安710038 )
Author(s):
YU Qingwei;  QIN Yanchang;  ZHANG Baiping;  et al.
Department of Neurosurgery, the Second Affiliated Hospital of Air Force Military Medical University(Xi’an 710038)
关键词:
神经胶质瘤; 长链非编码 RNA; AFAP1AS1; 预后; 组织学分级; KPS评分; 复发
Keywords:
Key words Glioma; Long noncoding RNA; AFAP1AS1; Prognosis; Histological classification; KPS score; Recur
分类号:
R392.3
文献标志码:
A
摘要:
摘 要 目的：探讨长链非编码RNA AFAP1AS1在胶质瘤组织中异常的表达情况以及影响患者预后的危险因素。方法：应用RTPCR法分别检测70例胶质瘤组织样本以及32例正常脑组织样本中lncRNA AFAP1AS1的表达水平，分析其与胶质瘤患者临床病理学特征之间的关系。用KaplanMeier和Logrank法分析患者5年生存率情况并进行检验，然后进行影响预后的单因素分析，最后用Cox比例风险回归模型进行多因素分析。结果：AFAP1AS1在胶质瘤组织中表达量明显高于正常组织并且其表达水平与胶质瘤患者的年龄、性别、肿瘤大小等无关，但与组织学分级、KPS评分以及是否复发有密切关系(P＜0.05)。高水平表达的AFAP1AS1、高病理级别以及KPS评分＜80分和术后复发均是影响患者术后预后的重要原因(P＜0.05)。结论：AFAP1AS1在胶质瘤组织中表达水平显著增高，AFAP1AS1高表达组患者术后生存率低，AFAP1AS1可以作为预测胶质瘤患者预后的重要指标。
Abstract:
Abstract Objective: To investigate the abnormal expression of long noncoding RNA AFAP1AS1 in glioma tissues and the risk factors affecting the prognosis of patients. Methods: The expression level of lncRNA AFAP1AS1 in 70 samples of glioma tissues and 32 normal brain tissue samples were detected by RTPCR, and the relationship between the clinicopathological features of glioma patients and gliomas was analyzed. The fiveyear survival rate of patients was analyzed by KaplanMeier and Logrank method, then the single factor analysis was carried out, and then the Cox proportional risk regression model was used to analyze the correlation between clinicopathological features and prognosis of glioma patients. Results: The expression of AFAP1AS1 in glioma tissue was significantly higher than that of normal tissue and its expression level was unrelated to the age, sex and tumor size of glioma patients, but it was closely related to histological grading, KPS scoring and recurrence (P＜0.05). Highlevel expression of AFAP1AS1 , high pathological level and KPS score ＜ 80 and postoperative recurrence were important factors that affected the postoperative prognosis of patients (P＜0.05). Conclusion: The expression level of AFAP1AS1 in glioma tissue was significantly increased, and the survival rate was low after AFAP1AS1 high expression group. AFAP1AS1 can be used as an important predictor of prognosis in patients with glioma.

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相似文献/References:

[1]于庆伟,秦彦昌,张百平,等.长链非编码RNAPOU3F3在胶质瘤中表达及影响预后的相关因素研究[J].陕西医学杂志,2019,(5):550.
　YU Qingwei,QIN Yanchang,ZHANG Baiping,et al.Expression of long noncoding RNA POU3F3 in gliomas and its prognostic factors[J].,2019,(3):550.

更新日期/Last Update: 2019-03-15