[1]杜 静,袁 勇△,陆建荣,等.CD10在甲状腺肿瘤组织中的表达及检测临床意义*[J].陕西医学杂志,2019,(2):248-251,255.
 DU Jing,YUAN Yong,LU Jianrong,et al.Expression and significance of CD10 in thyroid neoplasms[J].,2019,(2):248-251,255.
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CD10在甲状腺肿瘤组织中的表达及检测临床意义*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年2期
页码:
248-251,255
栏目:
临床病理
出版日期:
2020-02-05

文章信息/Info

Title:
Expression and significance of CD10 in thyroid neoplasms
文章编号:
DOI: 10.3969/j.issn.10007377.2019.02.030
作者:
杜 静1袁 勇2△陆建荣2陈诗缘1任栋栋2
1.西安医学院(西安710068);2.陕西省肿瘤医院(西安710061)
Author(s):
DU JingYUAN YongLU Jianronget al.
Xi’an Medical University(Xi’an 710068) 
关键词:
CD10腺瘤性甲状腺肿甲状腺滤泡性腺瘤甲状腺滤泡癌甲状腺乳头状癌甲状腺髓样癌甲状腺未分化癌 
Keywords:
Key words CD10Adenomatous goiterFollicular thyroid adenomaFollicular thyroid carcinomaPapillary thyroid carcinomaMedullary thyroid carcinomaUndifferentiated thyroid carcinoma 〖HK〗〖HT〗〖HJ1〗〖HJ〗
分类号:
R736.1
文献标志码:
A
摘要:
摘 要 目的:研究甲状腺肿瘤组织中CD10表达情况及意义。方法:收集137例手术切除的甲状腺结节的石蜡标本,其中男性98例,女性39例;年龄24~75岁,平均年龄50岁。包括9例腺瘤性甲状腺肿(AG)、13例甲状腺髓样癌(MTC)、16例甲状腺滤泡性腺瘤(FTA)、11例甲状腺滤泡癌(FTC)、48例甲状腺乳头状癌(PTC)和40例甲状腺未分化癌(ATC)。应用免疫组织化学(IHC)检测CD10在上述组织中的表达情况。结果:几乎所有的ATC上皮成分中显示CD10的弥散性和强阳性。伴有鳞状化生和嗜酸细胞化生的腺瘤性甲状腺肿、滤泡腺瘤和分化型癌的上皮细胞CD10表达呈局灶阳性表达。一些甲状腺乳头状癌(PTC),以及一些含有乳头状癌的未分化癌,在其成纤维细胞样基质细胞和纤维组织中显示CD10阳性。结论:甲状腺癌的组织亚型可根据CD10的表达情况来判定。尤其是在排除转移后,CD10对于ATC的诊断具有极大意义。
Abstract:
Abstract Objectives:To detect the expression and significance of CD10 in adenomatous goiter and thyroid tumor and explore its clinical significance. Methods: 137 paraffin specimens of thyroid nodules were collected, including 98 males and 39 females, aged from 24 to 75 years, with an average age of 50 years. There were 9 cases of adenomatous goiter (AG), 13 cases of medullary thyroid carcinoma (MTC), 16 cases of follicular thyroid adenoma (FTA), 11 cases of follicular thyroid carcinoma (FTC), 48 cases of papillary thyroid carcinoma (PTC) and 40 cases of undifferentiated thyroid carcinoma (ATC). Immunohistochemical staining (IHC) was used to detect the expression of CD10 in these tissues. Results:Almost all ATC epithelial components showed diffuse and strongly positivity for CD10. The expression of CD10 in epithelial cells with squamous metaplasia and eosinophilic metaplasia was locally positive. Some papillary thyroid carcinoma (PTC),along with the PTC component of some ATCs,showed CD10 positivity in fibroblastlike stromal cells and fibrous material. Conclusion:The tissue subtypes of thyroid carcinoma can be determined according to the expression of CD10. Especially after removing metastasis, CD10 have great significance for the diagnosis of ATC. 

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备注/Memo

备注/Memo:
*陕西省自然科学基础研究计划项目(2014JM4187)
更新日期/Last Update: 2019-03-13