[1]蒋永悟.妊娠期高血压患者尿蛋白和血常规水平分析及对妊娠结局的影响*[J].陕西医学杂志,2019,(1):128-130.
　JIANG Yongwu..Analysis of urinary protein and blood routine levels in patients with hypertensive disorder during pregnancy and its effect on pregnancy outcome[J].,2019,(1):128-130.
点击复制

妊娠期高血压患者尿蛋白和血常规水平分析及对妊娠结局的影响*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
128-130
栏目:
临床检验
出版日期:
2019-01-05

文章信息/Info

Title:
Analysis of urinary protein and blood routine levels in patients with hypertensive disorder during pregnancy and its effect on pregnancy outcome
文章编号:
DOI:10.3969/j.issn.10007377.2019.01.040
作者:
蒋永悟
陕西省安康市妇幼保健院检验科（安康725000）
Author(s):
JIANG Yongwu.
Clinical Laboratory of Ankang Maternal and Child Health Hospital(Ankang 725000)
关键词:
妊娠期高血压; 尿蛋白; 血常规; 妊娠结局; 对比研究
Keywords:
Key words Urine protein; Hypertension during pregnancy; Blood routine; Pregnancy outcome; Comparative study
分类号:
R714.2
文献标志码:
A
摘要:
摘 要 目的：研究妊娠期高血压患者尿蛋白和血常规水平分析及对妊娠结局的影响。方法：选取收治的妊娠期高血压疾病患者159例，其中妊娠期高血压组55例，轻度子痫前期组64例，重度子痫前期组40例，比较并分析三组患者的尿蛋白阳性率、BUN和Cr含量，血常规和凝血功能，包括血红蛋白（Hb）、血小板（PLT）、红细胞压积（HCT）、外周血红细胞（RBC）、纤维蛋白原（FIB）和凝血酶原时间（PT），以及不良妊娠结局的发生率，包括早产，低体重儿，子痫，胎盘早剥，胎儿生长受限，新生儿窒息，胎儿窘迫。结果：三组之间尿蛋白阳性率间差异有统计学意义（P＜0.05），重度子痫前期尿蛋白阳性率显著高于妊娠期高血压组和轻度子痫前期组（P＜0.05）。重度子痫前期组BUN和Cr显著高于妊娠期高血压组（P＜0.05）。三组之间PLT、HCT和RBC水平差异有统计学意义（P＜0.05），重度子痫前期组PLT和RBC水平显著低于妊娠期高血压组和轻度子痫前期组（P＜0.05）。重度子痫前期组FIB和PT显著低于妊娠期高血压组（P＜0.05）。三组之间早产、胎儿生长受限和胎盘早剥的发生率差异有统计学意义（P＜0.05）。结论：对妊娠期高血压疾病患者应定期进行尿蛋白和血常规水平的分析，以便尽早进行诊断和治疗，减少不良妊娠结局的发生。
Abstract:
AbstractObjective:To analyze the urinary protein and blood routine levels in patients with hypertensive disorder during pregnancy and its effect on pregnancy outcome. Methods:159 patients with hypertensive disorder complicating pregnancy were enrolled in our hospital, including 55 patients with gestational hypertension, 64 patients with mild preeclampsia, and 40 patients with severe preeclampsia.Compare and analyze urine protein, BUN and Cr levels, blood routine and coagulation functions, including Hb, PLT, HCT, RBC, FIB and PT, and adverse pregnancy outcomes, including preterm birth, low birth weight, eclampsia, Placental abruption, fetal growth restriction, neonatal asphyxia, fetal distress. Results:The urine protein ratio of the three groups was significantly different (P＜0.05). The urine protein ratio in severe preeclampsia was significantly higher than that in the pregnant hypertensive group and mild preeclampsia group (P＜0.05).BUN and Cr in the severe preeclampsia group were significantly higher than those in the hypertensive group (P＜0.05).The PLT, HCT and RBC levels were significantly different between the three groups (P＜0.05). The PLT and RBC levels in the severe preeclampsia group were significantly lower than those in the hypertensive group and the mild preeclampsia group (P＜0.05).The FIB and PT in the severe preeclampsia group were significantly lower than those in the hypertensive group (P＜0.05).The incidence of preterm birth, fetal growth restriction and placental abruption between the three groups was significantly different (P＜0.05). Conclusion:Patients with hypertensive disorder complicating pregnancy should be regularly analyzed for urinary protein and blood levels, in order to diagnose and treat as early as possible to reduce the incidence of adverse pregnancy outcomes.

参考文献/References:

[1]林彤,陈丽红,胡继芬,等. 妊娠期高血压的危险因素[J]. 中华高血压杂志,2015,23(1):8385. [2]王益群. 妊娠期高血压疾病相关影响因素及对妊娠结局影响的研究[J]. 中华全科医学,2015,13(4):602604. [3]阳子兑娣. 妊娠期高血压并发胎盘早剥96例临床分析[J]. 陕西医学杂志, 2016, 45(5):574576. [4]谢幸，苟文丽. 妇产科学［M］. 北京: 人民卫生出版社，2013: 6473. [5]Bindu KH, Devi ER. Effect of pregnancy induced hypertension on pregnancy outcome: a hospital based cross sectional study at a tertiary care hospital[J]. International Jourmal of Reproduction Contraception,2018,7(5):1984. [6]Leaásmiranda A, Méndezaguilar F, Ramírezvalenzuela K L,et al.Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes[J]. Medicine, 2017, 96(4):6063. [7]宋娟利.复方丹参注射液联合硫酸镁治疗妊娠期高血压疾病及对患者微炎症状态、肾功能的影响[J].陕西中医,2016,37(4):406407. [8]罗小琴,骆晓芳,杨玉,等. 随机尿微量白蛋白与尿肌酐比值在妊娠高血压疾病早期肾损伤的临床应用[J]. 现代妇产科进展,2015,24(4):279282. [9]赫艳梅,杨璐,李文瀚,等. 尿蛋白检测对妊娠期高血压疾病的诊断价值[J]. 中国妇幼保健,2015,30(20):35173518.〖ZK）〗 [10]〖JP4〗谢光亮, 徐先明, 朱琳,等. 妊娠期蛋白尿患者蛋白尿转归和妊娠结局的危险因素分析[J]. 上海医学, 2016，3:129133.

相似文献/References:

[1]徐 琳,贺菲菲△.糖尿病肾病患者血清铁代谢指标与尿蛋白排泄量相关性分析*[J].陕西医学杂志,2019,(10):1281.
　XU Ling,HE Feifei..Correlation between serum iron metabolism index and urine protein 〖JZ〗excretion in patients with diabetic nephropathy[J].,2019,(1):1281.
[2]冯思思,晋雅凌,邓科委△.妊娠期高血压胎儿预后及其与母体心脏形态功能相关性研究*[J].陕西医学杂志,2019,(12):1663.
[3]蒋晓颖,赵雪卉,张 娟.妊娠高血压早期肾损伤情况及其与血清视黄醇结合蛋白、尿酸关系研究[J].陕西医学杂志,2021,50(2):151.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.006]
　JIANG Xiaoying,ZHAO Xuehui,ZHANG Juan.Early renal injury in gestational hypertension and its relationship with serum sRBP and UA[J].,2021,50(1):151.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.006]
[4]陈园园,王利平.叶酸、维生素E联合硫酸镁治疗妊娠期高血压疗效及对患者血管内皮功能、Th1/Th2细胞水平的影响[J].陕西医学杂志,2021,50(2):208.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.021]
　CHEN Yuanyuan,WANG Liping.Efficacy of folic acid,vitamin E combined with magnesium sulfate in treatment of gestational hypertension and its effect on vascular endothelial function and Th1/Th2 cell level[J].,2021,50(1):208.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.021]
[5]张 丽,张 蕾,李 娜,等.妊娠期高血压患者血清circ-0002348和circ-0002814表达水平及其与妊娠结局相关性研究[J].陕西医学杂志,2025,54(2):197.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.010]
　ZHANG Li,ZHANG Lei,LI Na,et al.Expression levels of serum circ-0002348 and circ-0002814 in patients with hypertensive disorders of pregnancy and their correlation with pregnancy outcomes[J].,2025,54(1):197.[doi:DOI:10.3969/j.issn.1000-7377.2025.02.010]

备注/Memo

备注/Memo:
*陕西省科技攻关项目(2009K1602)
更新日期/Last Update: 2019-01-22