[1]尹树山,陶 艳,张红英.雌、孕激素受体在晚期局部乳腺癌中的表达及与患者预后相关性研究*[J].陕西医学杂志,2019,(12):1718-1721.
　YIN Shushan,TAO Yan,ZHANG Hongying..Analysis of expression of estrogen and progesterone receptor in patients with locally advanced breast cancer and its correlation with prognosis[J].,2019,(12):1718-1721.
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雌、孕激素受体在晚期局部乳腺癌中的表达及与患者预后相关性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年12期
页码:
1718-1721
栏目:
临床病理
出版日期:
2019-12-05

文章信息/Info

Title:
Analysis of expression of estrogen and progesterone receptor in patients with locally advanced breast cancer and its correlation with prognosis
文章编号:
DOI:10.3969/j.issn.10007377.2019.12.039
作者:
尹树山; 陶 艳; 张红英
四川省南充市高坪区人民医院肿瘤科 (南充 637100)
Author(s):
YIN Shushan; TAO Yan; ZHANG Hongying.
Oncology Department,Gaoping People’s Hospital,Nanchong City,Sichuan Province(Nanchong 637100)
关键词:
雌激素受体; 孕激素受体; 局部晚期乳腺癌; 预后; 相关性分析; 免疫组织化学
Keywords:
Key words Estrogen receptor; Progesterone recepto; Locally advanced breast cancer; The prognosis; Correlation analysis; Immunohistochemistry
分类号:
R737.9
文献标志码:
A
摘要:
摘 要 目的：分析雌、孕激素受体(ER、PR)在局部晚期乳腺癌中的表达及与患者预后相关性。方法：收集晚期乳腺癌患者96例，均经镜下取癌组织进行活检；另随机抽取46例患者进行癌旁组织采集，采用免疫组织化SP法检测两组ER、PR，并分析其表达水平与乳腺癌疾病的预后的关系，采用单因素和多因素Logistic回归分析ER、PR表达水平对晚期乳腺癌患者预后相关危险因素。结果：①癌组织中ER(-)与PR(-)例数均明显少于癌旁组织，癌组织中ER(+)、ER()、ER()、PR(+)例数均明显高于癌旁组织(P＜005)。②ER(+)者第1年存活率为4791%，明显低于ER(-)5833%，PR(+)者2年存活率为3645%，明显低于PR(-)5104%，差异具有统计学意义(P＜005)。③非条件单因素Logistic回归分析结果显示，年龄、肿瘤直径、ER与PR表达水平是影响晚期乳腺癌患者预后死亡单因素(P＜005)。④经非条件多因素Logistic回归模型分析结果显示,肿瘤直径≥2、ER(+)、PR(+)是影响患者预后死亡的独立危险因素(P＜0001)。结论：ER、PR在局部晚期乳腺癌患者癌组织中表达水平较癌旁组织高，ER、PR表达水平与肿瘤直径是影响局部晚期乳腺癌患者预后的危险因素，ER、PR表达阳性者病死率较高。
Abstract:
Abstract Objective:To analyze the expression of estrogen and progesterone receptor (ER,PR) in patients with locally advanced breast cancerMethods:Clinical data of 96 patients with locally advanced breast cancer treated were retrospectively analyzedFortysix patients were randomly selected for paracancerous tissue collectionImmunohistochemical SP method was used to detect ER and PR in the two groups,and the relationship between their expression level and the prognosis of breast cancer disease was analyzedResults:①The number of ER (-) and PR (-) in cancer tissue was significantly lower than that in paracancerous tissue,and the number of ER (+),ER (),ER (),and PR (+) in cancer tissue was significantly higher than that in paracancerous tissue (P＜005)②The 1year survival rate of ER (+) was 4791%,significantly lower than ER (-) 5833%,and the 2year survival rate of PR (+) was 3645%,significantly lower than PR (-) 5104%,with statistically significant difference (P＜005)③Nonconditional univariate Logistic regression analysis showed that age,tumor diameter,ER and PR expression levels were the single factors influencing the prognosis and death of patients with advanced breast cancer (P＜005)④Analysis results of nonconditional multivariate logistic regression model showed that tumor diameter ≥ 2,ER (+) and PR (+) were independent risk factors influencing the prognosis and death of patients (P＜0.001).Conclusion：The expression level of ER and PR in cancer tissues of locally advanced breast cancer patients is higher than that of adjacent tissuesThe expression level of ER and PR and tumor diameter are the risk factors affecting the prognosis of locally advanced breast cancer patients

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备注/Memo

备注/Memo:
*四川省卫生和计划生育委员会科研课题（105891637）
更新日期/Last Update: 2019-12-19