[1]李福泰,姚春虹△,慕廷民,等.急性脑梗死患者炎症因子与同型半胱氨酸、纤维蛋白原相关性研究*[J].陕西医学杂志,2019,(1):71-73.
　LI Futai,YAO Chunhong,MU Tingmin,et al.Correlation study between inflammatory factors andhomocysteine and fibrinogen in acute cerebral infarction patients[J].,2019,(1):71-73.
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急性脑梗死患者炎症因子与同型半胱氨酸、纤维蛋白原相关性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
71-73
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Correlation study between inflammatory factors andhomocysteine and fibrinogen in acute cerebral infarction patients
文章编号:
DOI:10.3969/j.issn.10007377.2019.01.022
作者:
李福泰;  姚春虹△; 慕廷民; 张东亚; 韩晓芳
延安大学咸阳医院（咸阳 712000）
Author(s):
LI Futai;  YAO Chunhong;  MU Tingmin;  et al.
Xianyang Hospital of Yan'an University (Xianyang 712000)
关键词:
急性脑梗死; 肿瘤坏死因子a; 白介素6; 同型半胱氨酸; 纤维蛋白原; 相关性
Keywords:
Key words Acute cerebral infarction; TNFa; IL6; Homocysteine; Fibrinogen; The correlation
分类号:
R743
文献标志码:
A
摘要:
摘 要 目的：探讨急性脑梗死患者炎症因子\[肿瘤坏死因子α(TNFα)及白介素6(IL6)\]与同型半胱氨酸（Hcy）、纤维蛋白原（FIB）的相关性研究。方法：选取急性脑梗死患者150例及同期健康体检者150例作为研究对象，分别作为病例组及对照组，FIB、Hcy及炎性因子分别利用免疫比浊法、循环酶法、酶联免疫吸附法检测，通过Pearson分析炎症因子TNFα、IL6与Hcy、FIB的相关性。结果：病例组炎性因子及FIB、Hcy均显著高于对照组，对比差异具有统计学意义（P＜0.05）。脑梗死患者炎性因子TNFα与FIB、Hcy均呈显著正相关（r=0.436，P=0.00；r=0.521，P=0.001）；IL6与FIB、Hcy均呈显著正相关（r=0.382，P=0.002；r=0.394，P=0.003）。联合四个指标的阳性率为97.33%（146/150），显著高于单一指标检测阳性率，对比差异具有统计学意义（P＜0.05）。结论：TNFα、IL6与Hcy、FIB均具有正相关性，能够反映病情严重程度，四个指标联合诊断急性脑梗死具有积极意义。
Abstract:
Abstract Objective: to investigate the relationship between tnfq and IL6 (IL6) and homocysteine (Hcy) and FIB in patients with acute cerebral infarction. Methods: 150 patients with acute cerebral infarction were selected as the subjects， as a case group and control group respectively， FIB， Hcy， inflammatory factor respectively using immune turbidimetric method， circulating enzymatic， enzymelinked immunosorbent method， through analysis of Pearson TNF alpha inflammation factors was analyzed， the correlation between IL  6 and Hcy，FIB. Results:The inflammatory factors, FIB and Hcy in the case group were significantly higher than those in the control group, and the comparison was significantly different (P＜0.05). Patients with cerebral infarction showed significant positive correlation between TNF conditioning and FIB and Hcy (r=0.436, P=0.00).R=0.521,P=0.001); IL6 has a significant positive correlation with FIB and Hcy (r=0.382,P=0.002). R=0.394,P=0.003). Combined with the four indicators, the positive rate was 97.33% (146/150), which was significantly higher than the positive rate detected by a single index, and the comparison was significantly different (P＜0.05). Conclusion: tnfq and il6 are positively correlated with Hcy and FIB， which can reflect the severity of the disease. The combined diagnosis of acute cerebral infarction by four indicators is of positive significance.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目（81401090）
更新日期/Last Update: 2019-01-22