[1]杨生琴.超早期小骨窗微创脑出血清除术后血清VEGF、Ang1、HPA水平变化及意义[J].陕西医学杂志,2019,(1):48-51.
　YANG Shengqin..Changes and significance of serum VEGF,Ang1 and HPA levels after minimally invasivesurgery for intracerebral hemorrhage with small bone window craniotomy in super early stage[J].,2019,(1):48-51.
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超早期小骨窗微创脑出血清除术后血清VEGF、Ang1、HPA水平变化及意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
48-51
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Changes and significance of serum VEGF,Ang1 and HPA levels after minimally invasivesurgery for intracerebral hemorrhage with small bone window craniotomy in super early stage
文章编号:
DOI:10.3969/j.issn.10007377.2019.01.015
作者:
杨生琴
青海省西宁市第一人民医院神经外科（西宁 810000）
Author(s):
YANG Shengqin.
Department of Neurosurgery,Xining First People's Hospital of Qinghai Province (Xining 810000)
关键词:
超早期; 小骨窗; 微创脑出血清除术; 血管内皮生长因子; 血管生成素1; 乙酰肝素酶
Keywords:
Key words Super early;  Small bone window;  Minimally invasive cerebral hemorrhage;  VEGF;  Ang1;  HPA
分类号:
R651.1
文献标志码:
A
摘要:
摘 要 目的：探讨血管内皮生长因子（VEGF）、血管生成素1（Ang1）及乙酰肝素酶（HPA）在预测超早期小骨窗微创治疗脑出血清除术后的意义。方法：选取进行治疗并行超早期小骨窗微创脑出血清除术的30例脑出血患者为为实验组，另选取同期于我院进行健康检查的30例健康者为对照组，分别于实验组术后24 h、48 h、5 d和10 d四个时间点采取实验组患者静脉血，对照组于健康检查次日清晨采静脉血，对两组患者血中VEGF、Ang1、HPA水平进行对比，并于上述4个时间点使用格拉斯哥昏迷评分（GCS）、Berg量表和NIHSS量表对两组患者的神经功能进行测定对比，分析血清因子的变化与患者功能的相关性。结果：实验组治疗后，随着时间的推移，其血清因子水平不断下降，但较对照组仍处于高水平。随着时间推移，实验组患者GCS、Berg量表及NIHSS量表得分呈现上升趋势，提示患者功能得到逐步恢复。结论：对脑出血患者实施超早期小骨窗微创脑出血清除术后，其血清VEGF、Ang1、HPA水平逐步下降，其神经、生活功能不断恢复，提示血清VEGF、Ang1、HPA的水平对预测手术预后具有一定意义。
Abstract:
Abstract Objective：To explore the significance of vascular endothelial growth factor (VEGF),angiopoietin1 (Ang1) and heparanase (HPA) in predicting the minimally invasive treatment of intracerebral hemorrhage after minimally invasive small bone window.Methods：30 patients with cerebral hemorrhage were enrolled in this study. The patients in the experimental group were treated with venous blood in the experimental group at 24h,48h,5d and 10d after operation. The control group was treated with venous blood in the early morning of the next day. (GCS),Berg scale and NIHSS scale were used to compare the neurological function of the two groups,and the changes of serum factor were compared with those of the patients Functional relevance.Results：Compared with the control group,the serum levels of GCS,Berg scale and NIHSS showed an increasing trend with the passage of time in the experimental group,and the serum level of the experimental group was higher than that of the control group ,Prompting the patient function to be gradually restored.Conclusion：The level of serum VEGF,Ang1 and HPA gradually decreased in the patients with intracerebral hemorrhage after intracerebral hemorrhage,and the nerve and life function of the patients with intracerebral hemorrhage were gradually restored. The levels of serum VEGF,Ang1 and HPA Level has a certain significance in predicting the prognosis of the operation.

参考文献/References:

[1] Martini SR,Flaherty ML,Brown WM,et al. Risk factors for intracerebral hemorrhage differ according to hemorrhage location.[J].Neurology,2012,79(23):22752282. [2] 张 芹,张拥波,李继梅.脑出血研究进展[J].神经损伤与功能重建,2013,23(6):249249. [3] 高 利,姜树军,牛俊英.高血压脑出血的临床研究进展[J].中西医结合心脑血管病杂志,2013,11(8):977979. [4] 黄 锐,直切口小骨窗经侧裂入路显微手术对高血压基底核区脑出血患者的预后研究[J]. 陕西医学杂志,2016,45(8):997998. [5] 张 宁,杨华堂.Glasgow昏迷量表在高血压性脑出血急救策略选择中的作用[J].中国现代神经疾病杂志,2017,17(3);223227. [6] 李锦泉,吴月峰,王建莉.脑出血偏瘫患者康复协调功能评定与血管活性物质相关性研究分析[J].浙江创伤外科,2013,18(3):430431. [7] Huang WC,Wu D,Xie Z,et al. Beta2microglobulin is a signaling and growthpromoting factor for human prostate cancer bone metastasis[J]. Cancer Research,2015,66(18):91089116. [8] Hao NB,Tang B,Wang GZ,et al. Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NFκB signaling pathway for gastric cancer metastasis.[J]. Cancer Letters,2015,361(1):5766. [9] 王 莹,王秀琴.脑出血患者不同时期血管内皮生长因子表达水平的变化[J].辽宁医学院学报,2016,37(5):2931.〖ZK）〗 [10] 董 滨,孙顺昌,王国峰,等.脑缺血耐受大鼠脑组织血管内皮生长因子和血管生成素1表达的改变及其意义[J].临床神经病学杂志,2012,25(1):3639. [11] 胡 涛.促血管生成素1蛋白减少大鼠尿激酶溶栓后脑出血转化及机制研究[J].中国药师,2016,19(8):14551459. [12] 许常林,李千红,裴 杰,等. 醒脑静配合微创手术治疗脑出血36例[J]. 陕西中医,2012,33(7):850851.

更新日期/Last Update: 2019-01-22