[1]赵懿,田俊斌,薛佳佳,等.甲苯磺酸瑞马唑仑在无痛胃肠镜诊疗中的有效性和安全性评价[J].陕西医学杂志,2026,(6):822-825,831.[doi:DOI:10.3969/j.issn.1000-7377.2026.06.017]
　ZHAO Yi,TIAN Junbin,XUE Jiajia,et al.Evaluation of efficacy and safety of remimazolam tosylate in painless gastrointestinal endoscopy[J].,2026,(6):822-825,831.[doi:DOI:10.3969/j.issn.1000-7377.2026.06.017]
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甲苯磺酸瑞马唑仑在无痛胃肠镜诊疗中的有效性和安全性评价

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年6期
页码:
822-825,831
栏目:
药物与临床
出版日期:
2026-06-05

文章信息/Info

Title:
Evaluation of efficacy and safety of remimazolam tosylate in painless gastrointestinal endoscopy
作者:
赵懿1; 田俊斌2; 薛佳佳3; 刘苗1; 王雨薇1; 肖娇4; 杨扬1; 王娜1
（1.西安交通大学第二附属医院药学部，陕西 西安 710004；2.西安交通大学第二附属医院麻醉科，陕西 西安 710004；3.西安市杨陵区揉谷卫生院药剂科，陕西 咸阳 712100；4.柞水县中医医院药剂科，陕西 柞水 711400）
Author(s):
ZHAO Yi1; TIAN Junbin2; XUE Jiajia3; LIU Miao1; WANG Yuwei1; XIAO Jiao4; YANG Yang1; WANG Na1
（1.Department of Pharmacy，the Second Affiliated Hospital of Xi’an Jiaotong University，Xi’an 710004，China;2.Department of Anesthesiology，the Second Affiliated Hospital of Xi’an Jiaotong University，Xi’an 710004，China;3.Yangling District Rougu Health Center，Xianyang 712100，China;4.Zhashui County Hospital of Traditional Chinese Medicine，Zhashui 711400，China）
关键词:
甲苯磺酸瑞马唑仑; 无痛胃肠镜; 丙泊酚; 镇静; 安全性; 有效性
Keywords:
Remimazolam tosylate; Painless gastrointestinal endoscopy; Propofol; Sedation; Safety; Effectiveness
分类号:
R 614
DOI:
DOI:10.3969/j.issn.1000-7377.2026.06.017
文献标志码:
A
摘要:
目的：探索甲苯磺酸瑞马唑仑在无痛胃肠镜诊疗中的有效性及安全性。方法：回顾性收集行无痛胃肠镜检查的35例患者，分为甲苯磺酸瑞马唑仑组和丙泊酚组。甲苯磺酸瑞马唑仑组初始给药剂量为5.0 mg，根据镇静情况追加2.5 mg/次；丙泊酚组初始剂量为1.5 mg/kg，根据镇静情况每次追加0.5 mg/kg，两次间隔均不少于1 min。比较两组患者的镇静效果、药物追加情况、不良反应发生情况以及麻醉过程中各时间点的血流动力学指标。结果：两组患者镇静成功率均为100%。甲苯磺酸瑞马唑仑组注射痛发生率显著低于丙泊酚组（P＜0.05）。未观察到两组患者在低血压、低血氧、呼吸抑制、心动过缓、头晕发生率上存在统计学差异（均P＞0.05）。尽管甲苯磺酸瑞马唑仑组的诱导时间长于丙泊酚组（P＜0.05），但两组患者镇静效果与两组药物追加率和频次比较无统计学差异（均P＞0.05）。甲苯磺酸瑞马唑仑组在T3及T4的HR显著高于丙泊酚组（均P＜0.05），两组患者MAP、SpO2 、RR各时间点组间比较无统计学差异（均P＞0.05）。结论：甲苯磺酸瑞马唑仑用于无痛胃肠镜诊疗的镇静效果与丙泊酚相当，同时能减少注射痛，可作为无痛胃肠镜诊疗镇静的新选择。
Abstract:
Objective:To investigate the efficacy and safety of Remimazolam tosylate in sedating patients undergoing painless gastrointestinal endoscopy.Methods：A retrospective analysis of 35 patients who underwent painless gastroscopy and colonoscopy was conducted，and they were divided into the remimazolam tosylate group and the propofol group.The initial dose of remimazolam tosylate was 5.0 mg，and 2.5 mg was added each time according to the sedation status;the initial dose of propofol was 1.5 mg/kg，and 0.5 mg/kg was added each time according to the sedation status，with an interval of no less than 1 minute between each addition.The sedation effect，drug addition situation，adverse reaction occurrence，and hemodynamic indicators at each time point during anesthesia were compared between the two groups.Results:The sedation success rate of both groups of patients was 100%.The incidence of injection pain in the remimazolam tosylate group was significantly lower than that in the propofol group (P<0.05).No statistically significant differences were observed in the incidences of hypotension，low blood oxygen，respiratory depression，bradycardia，and dizziness between the two groups of patients (all P>0.05).Although the induction time of the remimazolam tosylate group was longer than that of the propofol group (P<0.05)，there were no statistically significant differences in the sedation effects，the rate of drug addition，and frequency between the two groups (all P>0.05).The HR of the remimazolam tosylate group at T3 and T4 was significantly higher than that of the propofol group (all P<0.05)，and there were no statistically significant differences in MAP，SpO2，and RR at each time point between the two groups (all P>0.05).Conclusion:Remimazolam tosylate for sedation in painless gastroenterological endoscopy has an equivalent effect to propofol，and it can also reduce injection pain.It can be regarded as a new option for sedation in painless gastroenterological endoscopy.

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备注/Memo

备注/Memo:
国家卫生健康委医院管理研究所医院药学高质量发展研究项目（NIHAZX202426）
更新日期/Last Update: 2026-06-05