[1]李福军,张蓉,方堃,等.血清NGAL、KLF5水平对重症急性胰腺炎并发肺部感染的预测价值[J].陕西医学杂志,2026,(6):817-821,837.[doi:DOI:10.3969/j.issn.1000-7377.2026.06.016]
　LI Fujun,ZHANG Rong,FANG Kun,et al.Predictive value of serum NGAL and KLF5 levels for pulmonary infection in patients with severe acute pancreatitis[J].,2026,(6):817-821,837.[doi:DOI:10.3969/j.issn.1000-7377.2026.06.016]
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血清NGAL、KLF5水平对重症急性胰腺炎并发肺部感染的预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年6期
页码:
817-821,837
栏目:
临床研究
出版日期:
2026-06-05

文章信息/Info

Title:
Predictive value of serum NGAL and KLF5 levels for pulmonary infection in patients with severe acute pancreatitis
作者:
李福军; 张蓉; 方堃; 陈娟; 庄天时; 王超
（徐州医科大学附属徐州市立医院 徐州市第一人民医院急诊医学科，江苏 徐州 221003）
Author(s):
LI Fujun; ZHANG Rong; FANG Kun; CHEN Juan; ZHUANG Tianshi; WANG Chao
(Department of Emergency Medicine，Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University，Xuzhou 221003，China)
关键词:
重症急性胰腺炎; 肺部感染; 中性粒细胞明胶酶相关载脂蛋白; Kruppel样因子5; 预测价值
Keywords:
Severe acute pancreatitis; Pulmonary infection; Neutrophil gelatinase-associated lipocalin; Kruppel-like factor 5; Predictive value
分类号:
R 657.51
DOI:
DOI:10.3969/j.issn.1000-7377.2026.06.016
文献标志码:
A
摘要:
目的：探究血清中性粒细胞明胶酶相关载脂蛋白（NGAL）、Kruppel样因子5（KLF5）对重症急性胰腺炎（SAP）并发肺部感染（PI）的预测价值。方法：选取SAP患者80例为SAP组，根据患者在医院是否发生PI分为PI组和非PI组，各40例。另选取同期健康者80例为对照组。比较SAP组与对照组、PI组与非PI组一般资料及相关指标；Pearson法分析血清NGAL、KLF5与炎症因子的相关性；Logistic回归分析SAP并发PI的影响因素；四格表法分析血清NGAL、KLF5不同水平对SAP并发PI的相对危险度；受试者工作特征（ROC）曲线分析血清NGAL、KLF5对SAP并发PI的预测价值。结果：SAP组血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、NGAL、KLF5水平较对照组高（均P<0.05）。PI组血清IL-6、TNF-α、NGAL、KLF5水平较非PI组高（均P<0.05）。血清NGAL、KLF5与IL-6、TNF-α呈正相关（均P＜0.05）。NGAL、KLF5、IL-6、TNF-α水平升高为SAP并发PI的危险因素（均P＜0.05）。血清NGAL、KLF5高水平SAP患者并发PI的风险为低水平的1.842倍和2.183倍。血清NGAL、KLF5联合预测SAP并发PI的价值优于单项（均P＜0.05）。结论：SAP患者血清NGAL、KLF5表达升高，且并发PI的患者表达更高。NGAL、KLF5表达升高会增加SAP并发PI的风险。两项联合检测对预测SAP并发PI有良好的临床价值。
Abstract:
Objective:To discuss the predictive value of serum neutrophil gelatinase-associated lipocalin (NGAL) and Kruppel-like factor 5 (KLF5) levels for pulmonary infection (PI) in patients with severe acute pancreatitis (SAP).Methods：A total of 80 SAP patients were selected (SAP group)，and they were divided into the PI group and non-PI group based on whether PI occurred during hospitalization，with 40 cases in each group.Another 80 healthy individuals during the same period were selected as the control group.General data and related indicators of SAP group and control group，PI group and non-PI group were compared.The correlation between serum NGAL，KLF5 and inflammatory factors was analyzed by Pearson method.Logistic regression was used to analyze the influencing factors of SAP complicated with PI.The relative risk of SAP complicated with PI at different levels of serum NGAL and KLF5 was analyzed by fourfold table method.The predictive value of serum NGAL and KLF5 for SAP complicated with PI was analyzed by ROC curve.Results:The SAP group had higher serum IL-6，TNF-α，NGAL，and KLF5 than the control group (all P<0.05).The PI group had higher serum IL-6，TNF-α，NGAL，and KLF5 than the non-PI group (all P<0.05).Serum NGAL and KLF5 were positively correlated with IL-6 and TNF-α (all P<0.05).Elevated levels of NGAL，KLF5，IL-6，and TNF-α were risk factors of SAP complicated with PI (all P<0.05).The risk of PI with high levels of serum NGAL and KLF5 in SAP patients were 1.842 times and 2.183 times that of those with low levels，respectively.The combined prediction value of serum NGAL and KLF5 for SAP complicated with PI was superior to that of either single marker (all P<0.05).Conclusion:The serum NGAL and KLF5 levels are elevated in patients with SAP，and the levels are even higher in those with concurrent PI.The increase in NGAL and KLF5 expression increases the risk of SAP complicated with PI.The combined detection of these two indicators has good clinical value in predicting the occurrence of SAP complicated with PI.

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备注/Memo

备注/Memo:
江苏省研究型医院学会重大疾病炎症风暴防治专项科研基金资助项目（SYHKJ-XF-2025-13）
更新日期/Last Update: 2026-06-05