[1]陈盈玲,陈京京,单浩杰,等.2型糖尿病患者连续血糖监测严格范围内时间与骨代谢、骨密度相关性分析[J].陕西医学杂志,2026,(6):801-806.[doi:DOI:10.3969/j.issn.1000-7377.2026.06.013]
　CHEN Yingling,CHEN Jingjing,SHAN Haojie,et al.Correlation between TITR reflected by CGM and bone metabolism,BMD in T2DM patients[J].,2026,(6):801-806.[doi:DOI:10.3969/j.issn.1000-7377.2026.06.013]
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2型糖尿病患者连续血糖监测严格范围内时间与骨代谢、骨密度相关性分析

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年6期
页码:
801-806
栏目:
临床研究
出版日期:
2026-06-05

文章信息/Info

Title:
Correlation between TITR reflected by CGM and bone metabolism,BMD in T2DM patients
作者:
陈盈玲1; 2; 陈京京1; 2; 单浩杰2; 蒋伏松1; 2; 于晓巍2
（1.江西中医药大学，江西 南昌 330004；2.上海交通大学医学院附属第六人民医院，上海 200233）
Author(s):
CHEN Yingling1; 2; CHEN Jingjing1; 2; SHAN Haojie2; JIANG Fusong1; 2; YU Xiaowei2
(1.Jiangxi University of Chinese Medicine,Nanchang 330004,China;2.Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China)
关键词:
2型糖尿病; 骨代谢; 骨密度; 骨质疏松; 连续血糖监测; 严格范围内时间
Keywords:
Type 2 diabetes mellitus; Bone metabolism; Bone mineral density; Osteoporosis; Continuous glucose monitoring; Time in tight range
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2026.06.013
文献标志码:
A
摘要:
目的：探究2型糖尿病(T2DM)患者连续血糖监测(CGM)所反映的严格范围内时间(TITR)与骨代谢指标包括骨钙素N端中分子片段（N-MID OC）、Ⅰ型前胶原氨基端前肽（PINP）、甲状旁腺激素（PTH）、β胶原降解产物（β-CTX）、25-羟基维生素D3[25(OH)D3]、降钙素（CT）以及骨密度（BMD）的相关性。方法：纳入住院T2DM患者414例，所有受试者均接受72 h CGM，并计算TITR。依据患者的BMD检测结果，将其分为骨量正常组（155例）、骨量减少组（164例）和骨质疏松组（95例）。检测所有患者血清骨代谢指标及BMD值和其他生化指标水平。TITR与骨代谢指标和BMD的相关性采用偏相关性分析和多元线性回归分析进行，并控制年龄、性别、体重指数（BMI）、高密度脂蛋白胆固醇等混杂因素。结果：根据患者BMD进行分组后发现，随着骨量减少严重程度的显著增加，患者的年龄显著增加，BMI显著降低，且女性骨质疏松的发生率显著高于男性（均P<0.05）。不同组别之间高密度脂蛋白、N-MID OC、β-CTX和CT比较差异有统计学意义(均P＜0.05)。偏相关性分析结果显示，TITR与N-MID OC呈正相关(P＜0.05)，与PINP、PTH、β-CTX、25(OH)D3、CT和腰椎BMD、髋部BMD、股骨颈BMD无显著相关性(均P>0.05)。多元线性回归分析结果显示，TITR与N-MID OC呈正相关(β=0.051，95%CI：0.020～0.083，P=0.002)。结论：T2DM患者TITR与骨代谢指标N-MID OC水平呈正相关。
Abstract:
Objective:To explore the correlation between time in tight range (TITR) reflected by continuous glucose monitoring (CGM) in patients with type 2 diabetes mellitus (T2DM) and bone metabolism indicators including osteocalcin N-terminal midfragment (N-MID OC),pro-collagen type I amino terminal propeptide (PINP),parathyroid hormone (PTH),β-collagen degradation products (β-CTX),25-hydroxyvitamin D3 [25(OH)D3],calcitonin (CT),and bone mineral density (BMD).Methods：A total of 414 hospitalized T2DM patients were enrolled,all of whom underwent 72 hours of CGM and the calculation of TITR.Based on the results of the patients’ BMD tests,they were divided into normal bone mass group (155 cases),reduced bone mass group (164 cases),and osteoporosis group(95 cases).Serum bone metabolism markers,BMD values,and other biochemical indicators were measured for all patients.The correlation of TITR with bone metabolism markers and BMD was analyzed using partial correlation analysis and multiple linear regression analysis,controlling for confounding factors such as age,gender,BMI,and high-density lipoprotein cholesterol.Results:After grouping according to BMD,it was found that with the significant increase in the severity of bone loss,patients’ age increased significantly,BMI decreased significantly,and the incidence of osteoporosis was significantly higher in women than in men (all P<0.05).There were statistically significant differences in high-density lipoprotein,N-MID OC,β-CTX and CT among different groups (all P<0.05).The results of the partial correlation analysis showed that TITR was positively correlated with N-MID OC (P<0.05),and there were no significant correlations with PINP,PTH,β-CTX,25(OH)D3,CT,lumbar BMD,hip BMD,and femoral neck BMD (all P>0.05).The results of the multiple linear regression analysis indicated that TITR was positively correlated with N-MID OC (β=0.051,95%CI:0.020 to 0.083,P=0.002).Conclusion:TITR is positively correlated with the bone metabolism indicator N-MID OC level in T2DM patients.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82372387）；上海交通大学医工交叉研究基金资助项目（YG2024ZD19）
更新日期/Last Update: 2026-06-05