[1]赵 娜,迪娜·海沙尔,刘韦冰,等.上皮性卵巢癌患者血清FBLN-1、PP2A、ST2水平变化及其与预后关系研究[J].陕西医学杂志,2026,(5):648-652.[doi:DOI:10.3969/j.issn.1000-7377.2026.05.013]
　ZHAO Na,DINA Haishaer,LIU Weibing,et al.Changes in serum FBLN-1,PP2A and ST2 levels in patients with epithelial ovarian cancer and their relationship with prognosis[J].,2026,(5):648-652.[doi:DOI:10.3969/j.issn.1000-7377.2026.05.013]
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上皮性卵巢癌患者血清FBLN-1、PP2A、ST2水平变化及其与预后关系研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年5期
页码:
648-652
栏目:
临床研究
出版日期:
2026-05-05

文章信息/Info

Title:
Changes in serum FBLN-1,PP2A and ST2 levels in patients with epithelial ovarian cancer and their relationship with prognosis
作者:
赵 娜1; 迪娜·海沙尔2; 刘韦冰1; 邵 玲1
（1.辽宁省人民医院检验科，辽宁 沈阳 110031；2.福建医科大学附属第一医院检验科，福建 福州 350005）
Author(s):
ZHAO Na1; DINA Haishaer2; LIU Weibing1; SHAO Ling1
(1.Department of Clinical Laboratory,the People’s Hospital of Liaoning Province,Shenyang 110031,China;2.Department of Clinical Laboratory,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)
关键词:
上皮性卵巢癌; 腓骨蛋白-1; 蛋白磷酸酯酶2A; 生长刺激表达基因2蛋白; 预后; 影响因素
Keywords:
Epithelial ovarian cancer; Fibulin-1; Protein phosphatase 2A; Growth-stimulated expressed gene 2 protein; Prognosis; Influencing factors
分类号:
R737.31
DOI:
DOI:10.3969/j.issn.1000-7377.2026.05.013
文献标志码:
A
摘要:
目的：探讨上皮性卵巢癌（EOC）患者血清腓骨蛋白-1（FBLN-1）、蛋白磷酸酯酶2A（PP2A）、生长刺激表达基因2蛋白（ST2）水平变化及其与预后的关系。方法：选取EOC患者130例为EOC组，另选同期100例健康者为对照组。检测血清FBLN-1、PP2A、ST2水平。随访1年，按生存或复发情况分为预后不良组（42例）和预后良好组（88例）。EOC患者预后的影响因素以多因素Logistic回归进行分析。血清FBLN-1、PP2A、ST2对EOC患者预后的预测价值通过绘制受试者工作特征（ROC）曲线进行分析。结果：EOC组血清FBLN-1、ST2 水平高于对照组，PP2A水平较对照组降低（均P＜0.05）。与预后良好组比较，预后不良组血清FBLN-1、ST2水平升高，PP2A水平降低（均P＜0.05）。预后不良组国际妇产科联盟（FIGO）分期Ⅲ期、有腹水、肿瘤低分化、有淋巴结转移患者比例高于预后良好组（均P＜0.05）。影响EOC患者预后的因素包括血清FBLN-1、PP2A、ST2及FIGO分期、淋巴结转移、腹水、肿瘤分化程度（均P<0.05）。血清FBLN-1、PP2A、ST2联合预测EOC患者预后不良的曲线下面积（AUC）为0.901，较各指标单独预测的AUC高（均P<0.05）。结论：EOC患者血清FBLN-1、ST2水平上升，PP2A水平下降，均为预后不良的影响因素，三者联合对预后具有一定预测效能。
Abstract:
Objective:To investigate the changes in serum levels of fibulin-1 (FBLN-1),protein phosphatase 2A (PP2A),and growth-stimulated expressed gene 2 protein (ST2) in patients with epithelial ovarian cancer (EOC) and their relationship with prognosis.Methods：A total of 130 patients with EOC were enrolled as the EOC group,and 100 healthy individuals were selected as the control group.Serum levels of FBLN-1,PP2A and ST2 were measured.Patients were followed up for one year and divided into a poor prognosis group (42 cases) and a good prognosis group (88 cases) based on survival or recurrence status.Multivariate logistic regression analysis was performed to identify factors influencing the prognosis of EOC patients.The predictive value of serum FBLN-1,PP2A and ST2 for prognosis in EOC patients was evaluated by ROC curve analysis.Results:Serum levels of FBLN-1 and ST2 in the EOC group were higher than those in the control group,while PP2A level was lower (all P<0.05).Compared with the good prognosis group,the poor prognosis group showed elevated serum FBLN-1 and ST2 levels and decreased PP2A level (all P<0.05).The proportions of patients with FIGO stage Ⅲ,ascites,poorly differentiated tumors,and lymph node metastasis in the poor prognosis group were higher than those in the good prognosis group (all P<0.05).Factors affecting the prognosis of EOC patients included serum FBLN-1,PP2A,ST2,FIGO stage,lymph node metastasis,ascites,and tumor differentiation degree (all P<0.05).The AUC of the combined prediction of serum FBLN-1,PP2A and ST2 for poor prognosis in EOC patients was 0.901,which was higher than that of each individual indicator (all P<0.05).Conclusion:Elevated serum FBLN-1 and ST2 levels and decreased PP2A level in EOC patients are risk factors for poor prognosis.The combination of these three biomarkers demonstrates favorable predictive efficacy for prognosis.

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备注/Memo

备注/Memo:
辽宁省重点研发计划项目（2023LRZX-12325）
更新日期/Last Update: 2026-05-05