[1]于彤,张润宁,杜婴.蛋白激酶C δ在阿尔茨海默病病理损害中的作用及机制研究进展[J].陕西医学杂志,2026,(4):566-571.[doi:DOI:10.3969/j.issn.1000-7377.2026.04.024]
　YU Tong,ZHANG Running,DU Ying.Advances in the role and mechanisms of PKCδ in pathological damage of Alzheimer’s disease[J].,2026,(4):566-571.[doi:DOI:10.3969/j.issn.1000-7377.2026.04.024]
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蛋白激酶C δ在阿尔茨海默病病理损害中的作用及机制研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年4期
页码:
566-571
栏目:
综述
出版日期:
2026-04-05

文章信息/Info

Title:
Advances in the role and mechanisms of PKCδ in pathological damage of Alzheimer’s disease
作者:
于彤1; 张润宁1; 杜婴2
（1.陕西中医药大学，陕西 咸阳 712000；2.空军军医大学第二附属医院神经内科，陕西 西安 710000）
Author(s):
YU Tong1; ZHANG Running1; DU Ying2
（1.Shaanxi University of Chinese Medicine,Xianyang 712000,China;2.Department of Neurology,The Second Affiliated Hospital of Air Force Medical University,Xi’an 710000,China）
关键词:
阿尔茨海默病; 蛋白激酶Cδ; β淀粉样蛋白; 细胞凋亡; 突触可塑性; 神经炎症
Keywords:
Alzheimer’s disease; Protein kinase Cδ; Amyloid βprotein; Apoptosis; Synaptic plasticity; Neuroinflammation
分类号:
R 742
DOI:
DOI:10.3969/j.issn.1000-7377.2026.04.024
文献标志码:
A
摘要:
蛋白激酶Cδ（PKCδ）是新型PKC亚家族的重要成员，在大脑信号网络中发挥关键调节作用。近年来研究表明，PKCδ在阿尔茨海默病（AD）的病理进程中扮演着重要角色，主要通过调控β淀粉样蛋白（Aβ）的过量生成、损害突触可塑性、诱导神经细胞凋亡和促进神经炎症等多重机制参与疾病发生发展。本综述系统总结了PKCδ在AD病理损害中的作用机制，分析了其作为潜在治疗靶点的可行性与挑战，为基于PKCδ调控的AD防治策略提供理论依据。
Abstract:
Protein kinase Cδ （PKCδ）,a crucial member of the novel PKC subfamily,plays a pivotal regulatory role in brain signaling networks.Recent studies have demonstrated that PKCδ participates significantly in the pathological progression of Alzheimer’s disease （AD） through multiple mechanisms including regulation of excessive amyloid βprotein （Aβ） generation,impairment of synaptic plasticity,induction of neuronal apoptosis,and promotion of neuroinflammation.This review systematically summarizes the mechanisms of PKCδ in AD pathological damage,analyzes the feasibility and challenges of targeting PKCδ as a potential therapeutic approach,and provides theoretical foundation for PKCδbased AD prevention and treatment strategies.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82171406）
更新日期/Last Update: 2026-04-05