[1]吴菲,王伟伟,李静,等.血清IL-33、FOXM1水平对新生儿肺炎预后的预测价值[J].陕西医学杂志,2026,(3):402-405,418.[doi:DOI:10.3969/j.issn.1000-7377.2026.03.019]
　WU Fei,WANG Weiwei,LI Jing,et al.Predictive value of serum IL-33 and FOXM1 levels for prognosis of neonatal pneumonia[J].,2026,(3):402-405,418.[doi:DOI:10.3969/j.issn.1000-7377.2026.03.019]
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血清IL-33、FOXM1水平对新生儿肺炎预后的预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
402-405,418
栏目:
临床检验
出版日期:
2026-03-05

文章信息/Info

Title:
Predictive value of serum IL-33 and FOXM1 levels for prognosis of neonatal pneumonia
作者:
吴菲; 王伟伟; 李静; 陈惠兰
（青岛市妇女儿童医院新生儿科，山东 青岛 266011）
Author(s):
WU Fei; WANG Weiwei; LI Jing; CHEN Huilan
(Department of Neonatology,Qingdao Women and Children’s Hospital,Qingdao 266011,China)
关键词:
新生儿肺炎; 白细胞介素-33; 叉头框蛋白M1; 预后; 预测价值
Keywords:
Neonatal pneumonia; Interleukin-33; Forkhead box M1; Prognosis; Predictive value
分类号:
R 722.135
DOI:
DOI:10.3969/j.issn.1000-7377.2026.03.019
文献标志码:
A
摘要:
目的：探讨血清白细胞介素-33（IL-33）、叉头框蛋白M1（FOXM1）水平对新生儿肺炎预后的预测价值。方法：选取196例新生儿肺炎病例为研究对象，采用酶联免疫吸附试验（ELISA）法检测血清IL-33、FOXM1水平。治疗后对患儿进行预后评估，并分别纳入预后良好组和预后不良组。Pearson法分析新生儿肺炎预后不良患儿血清IL-33与FOXM1水平的相关性。Logistic回归分析预后影响因素。受试者工作特征（ROC）曲线分析预测价值。结果：经治疗，57例患儿预后不良。预后不良组血清降钙素原（PCT）、C-反应蛋白（CRP）、IL-33、FOXM1水平高于预后良好组（均P<0.05）。预后不良患儿血清IL-33与FOXM1水平呈正相关（P<0.05）。血清IL-33、FOXM1水平升高是预后的独立危险因素（均P<0.05）。血清IL-33、FOXM1联合预测患儿预后不良的价值高于单项（均P<0.05）。结论：新生儿肺炎预后不良患儿血清IL-33、FOXM1水平高于预后良好患儿，两者呈正相关且均为预后影响因素，两者联合检测具有良好的预测价值。
Abstract:
Objective:To explore the predictive value of serum interleukin-33 (IL-33) and forkhead box M1 (FOXM1) levels for the prognosis of neonatal pneumonia.Methods：A total of 196 cases of neonatal pneumonia were selected as the research subjects.The levels of serum IL-33 and FOXM1 were detected by ELISA.After treatment,the prognosis of the children was evaluated and they were respectively included in the good prognosis group and the poor prognosis group.The correlation between the serum IL-33 and FOXM1 levels of children with poor prognosis was analyzed by Pearson method.Logistic regression was used to analyze the influencing factors of prognosis.ROC curve was used to analyze the predictive value.Results:After treatment,57 children had a poor prognosis.The levels of serum PCT,CRP,IL-33 and FOXM1 in the poor prognosis group were higher than those in the good prognosis group (all P<0.05).The serum levels of IL-33 and FOXM1 were positively correlated in the poor prognosis children (P<0.05).Elevated serum levels of IL-33 and FOXM1 were independent risk factors for prognosis (all P<0.05).The combined prediction value of serum IL-33 and FOXM1 for poor prognosis of children was higher than that of either one alone (all P<0.05).Conclusion:The levels of serum IL-33 and FOXM1 in neonates with poor prognosis of pneumonia are higher than those in neonates with good prognosis.The two indicators are positively correlated and both are factors influencing prognosis.The combined detection of the two indicators has good predictive value.

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备注/Memo

备注/Memo:
山东省自然科学基金资助项目（ZR2024MH239）；山东省青岛市医疗卫生科研项目（2024-WJKY115）
更新日期/Last Update: 2026-03-05