[1]甘剑,孙健.尖锐湿疣皮损组织中Smac、HIF-1α、ATG5表达与患者临床病理特征及复发关系研究[J].陕西医学杂志,2026,(2):268-272.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.023]
　GAN Jian,SUN Jian.Expression of Smac,HIF-1α and ATG5 in condyloma acuminatum lesions and their relationship with clinicopathological characteristics and recurrence[J].,2026,(2):268-272.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.023]
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尖锐湿疣皮损组织中Smac、HIF-1α、ATG5表达与患者临床病理特征及复发关系研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年2期
页码:
268-272
栏目:
临床病理
出版日期:
2026-02-05

文章信息/Info

Title:
Expression of Smac,HIF-1α and ATG5 in condyloma acuminatum lesions and their relationship with clinicopathological characteristics and recurrence
作者:
甘剑; 孙健
（锦州医科大学附属第一医院皮肤科，辽宁 锦州 121001）
Author(s):
GAN Jian; SUN Jian
(Department of Dermatology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
关键词:
尖锐湿疣; 第二个线粒体衍生半胱天冬氨酸蛋白酶激活剂; 缺氧诱导因子-1α; 自噬相关基因5; 临床病理特征; 复发
Keywords:
Condyloma acuminatum; Second mitochondria-derived activator of caspase; Hypoxia inducible factor-1α; Autophagy-related gene 5; Clinicopathological characteristics; Recurrence
分类号:
R 752.53
DOI:
DOI:10.3969/j.issn.1000-7377.2026.02.023
文献标志码:
A
摘要:
目的：探讨尖锐湿疣（CA）皮损组织中第二个线粒体衍生半胱天冬氨酸蛋白酶激活剂（Smac）、缺氧诱导因子-1α（HIF-1α）、自噬相关基因5(ATG5)表达与患者临床病理特征和复发的关系。方法：选取98例CA患者为CA组，选同期非皮肤病、因其他原因切除外生殖器正常皮肤组织的志愿者85例为对照组。免疫组织化学染色法检测组织中Smac、HIF-1α、ATG5蛋白表达。随访6个月，记录复发情况。以四格表法分析皮损组织Smac、HIF-1α、ATG5蛋白表达对CA患者复发的预测价值。结果：与对照组正常皮肤组织比较，CA组皮损组织中Smac、ATG5蛋白阳性表达率降低，HIF-1α阳性表达率升高（均P＜0.05）。不同病程CA患者Smac、HIF-1α、ATG5蛋白阳性表达率比较差异无统计学意义（均P＞0.05）。不同病变范围、疣体数目、尿道受累、HPV感染类型患者皮损组织Smac、HIF-1α、ATG5蛋白阳性表达率比较差异有统计学意义（均P＜0.05）。随访6个月，98例CA患者复发40例，未复发58例。Smac蛋白阳性患者复发率10.53%低于Smac阴性患者48.10%，HIF-1α蛋白阳性患者复发率87.65%高于HIF-1α阴性患者11.76%，ATG5蛋白阳性患者复发率11.54%低于ATG5阴性患者50.00%（均P＜0.05）。皮损组织Smac、HIF-1α、ATG5蛋白表达联合预测CA患者复发的敏感度92.50%、特异度91.38%、阳性预测值88.10%、阴性预测值91.38%、准确率91.84%，高于单独指标预测（均P＜0.05）。结论：Smac、HIF-1α、ATG5在CA皮损组织中异常表达，与临床病理特征及复发风险有关，三者联合对CA患者复发具有一定预测价值。
Abstract:
Objective:To investigate the expression of second mitochondria-derived activator of caspase (Smac),hypoxia inducible factor-1α(HIF-1α),and sutophagy-related gene 5 (ATG5) in condyloma acuminatum (CA) lesions and their relationship with clinicopathological characteristics and recurrence.Methods：A total of 98 CA patients were enrolled as the CA group,and 85 volunteers who underwent excision of normal external genital skin tissue for non-dermatological reasons during the same period served as the control group.Immunohistochemical staining was used to detect the protein expression of Smac,HIF-1α and ATG5 in tissue samples.Patients were followed up for 6 months to record recurrence.A 2×2 contingency table was used to analyze the predictive value of Smac,HIF-1α and ATG5 protein expression for recurrence in CA patients.Results:Compared with normal skin tissue in the control group,the positive expression rates of Smac and ATG5 proteins were significantly lower,while the positive expression rate of HIF-1α was significantly higher in CA lesion tissues (all P<0.05).There was no significant difference in the positive expression rates of Smac,HIF-1α,and ATG5 among CA patients with different disease durations (all P>0.05).However,significant differences were observed in the positive expression rates of these proteins among patients with different lesion extents,numbers of warts,urethral involvement,and HPV infection types (all P<0.05).During the 6-month follow-up,40 of 98 CA patients experienced recurrence,while 58 did not.The recurrence rate in Smac-positive patients (10.53%) was significantly lower than in Smac-negative patients (48.10%).The recurrence rate in HIF-1α-positive patients (87.65%) was significantly higher than in HIF-1α-negative patients (11.76%).The recurrence rate in ATG5-positive patients (11.54%) was significantly lower than in ATG5-negative patients (50.00%) (all P<0.05).The combined prediction model based on Smac,HIF-1α,and ATG5 expression achieved a sensitivity of 92.50%,specificity of 91.38%,positive predictive value of 88.10%,negative predictive value of 91.38%,and accuracy of 91.84%,which were significantly higher than those of individual predictors (all P<0.05).Conclusion:Abnormal expression of Smac,HIF-1α,and ATG5 in CA lesion tissues is associated with clinicopathological characteristics and recurrence risk.The combined detection of these three markers holds predictive value for recurrence in CA patients.

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备注/Memo

备注/Memo:
辽宁省教育厅基本科研项目（JYTMS20230678）
更新日期/Last Update: 2026-02-04