[1]谷田,马瑛,黄丽萨,等.罗补甫克比日丸联合他莫昔芬、左卡尼汀治疗少弱精子症临床价值研究[J].陕西医学杂志,2026,(2):253-257.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.020]
　GU Tian,MA Ying,HUANG Lisa,et al.Clinical value of Lubofukebiri pills combined with tamoxifen and L-carnitine in the treatment of oligoasthenozoospermia[J].,2026,(2):253-257.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.020]
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罗补甫克比日丸联合他莫昔芬、左卡尼汀治疗少弱精子症临床价值研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年2期
页码:
253-257
栏目:
药物与临床
出版日期:
2026-02-05

文章信息/Info

Title:
Clinical value of Lubofukebiri pills combined with tamoxifen and L-carnitine in the treatment of oligoasthenozoospermia
作者:
谷田1; 2; 马瑛2; 黄丽萨2; 曹少姗2; 曹德宏1
（1.四川大学华西医院泌尿外科，四川 成都 610041；2.绵阳市中心医院 电子科技大学医学院附属绵阳医院生殖中心，四川 绵阳 621000）
Author(s):
GU Tian1; 2; MA Ying2; HUANG Lisa2; CAO Shaoshan2; CAO Dehong1
(1.Department of Urology,West China Hospital,Sichuan University,Chengdu 610041,China;2.Reproductive Center,Mianyang Central Hospital,Mianyang 621000,China)
关键词:
少弱精子症; 罗补甫克比日丸; 左卡尼汀; 他莫昔芬; 精液质量; 助孕结局
Keywords:
Oligoasthenozoospermia; Lubofukebiri pills; L-carnitine; Tamoxifen; Semen quality; Assisted reproductive outcomes
分类号:
R 698.2
DOI:
DOI:10.3969/j.issn.1000-7377.2026.02.020
文献标志码:
A
摘要:
目的：探讨罗补甫克比日丸联合他莫昔芬、左卡尼汀治疗少弱精子症的临床价值。方法：选取少弱精子症患者280例，随机分为联合组（140例）和对照组（140例）。对照组在他莫昔芬基础上给予左卡尼汀治疗，联合组在对照组基础上联合罗补甫克比日丸治疗。比较两组患者临床疗效、精液质量（精液量、精子浓度、前向运动A级精子百分率、前向运动A级+B级精子百分率）、血清性激素水平[睾酮(T)、黄体生成素(LH)、促卵泡生成素(FSH)]、治疗后的助孕结局[双原核(2PN)受精率、优质胚胎率、2PN卵裂率、临床妊娠率、多胎妊娠率、早期流产率]和治疗期间不良反应。结果：与对照组比较，联合组经治疗后的临床疗效总有效率更高(P<0.05)。相较于治疗前，两组患者治疗后前向运动A级精子百分率、精子浓度、前向运动A级+B级精子百分率以及血清T、LH、FSH水平升高，且联合组治疗后较对照组更高(均P<0.05)。治疗后，联合组2PN受精率、优质胚胎率较对照组升高(均P<0.05)。两组获卵数、2PN卵裂率、临床妊娠率、多胎妊娠率、早期流产率比较差异无统计学意义(均P>0.05)。两组患者治疗期间总不良反应发生率比较差异无统计学意义(P>0.05)。结论：罗补甫克比日丸联合他莫昔芬、左卡尼汀治疗少弱精子症疗效较好，能够调节血清性激素水平，改善精液质量，增加2PN受精率和优质胚胎率，且安全性良好。
Abstract:
Objective:To investigate the clinical value of Lubofukebiri pills combined with tamoxifen and L-carnitine in the treatment of oligoasthenozoospermia.Methods：A total of 280 patients diagnosed with oligoasthenozoospermia were randomly divided into a combination group and a control group,with 140 cases in each group.The control group was given L-carnitine on the basis of tamoxifen,while the combination group was combined with Luobufukebiri pills on the basis of the control group.The clinical efficacy,semen quality (semen volume,sperm concentration,percentage of progressively motile grade A sperm,percentage of progressively motile grade A+B sperm),serum sex hormones (testosterone [T],luteinizing hormone [LH],follicle-stimulating hormone[FSH]),assisted pregnancy outcomes after treatment (double pronuclear [2PN] fertilization rate,2PN cleavage rate,high-quality embryo rate,clinical pregnancy rate,multiple pregnancy rate,early abortion rate) and adverse reactions during treatment were compared between the two groups.Results:Compared with the control group,the combination group showed a significantly higher overall effective rate (P<0.05).After treatment,both groups exhibited improvements in the percentage of grade A motile sperm,sperm concentration,percentage of grade A+B motile sperm,and serum levels of T,LH and FSH,with significantly greater improvements observed in the combination group (all P<0.05).The 2PN cleavage rate and high-quality embryo rate were also significantly higher in the combination group (all P<0.05).There were no statistically significant differences between the two groups in terms of oocyte retrieval number,2PN cleavage rate,clinical pregnancy rate,multiple pregnancy rate,or early miscarriage rate (all P>0.05).No significant difference was observed in the overall incidence of adverse reactions between the two groups (P>0.05).Conclusion:Lubofukebiri pills combined with tamoxifen and L-carnitine is effective in treating oligoasthenozoospermia.This combination can regulate serum sex hormone levels,improve semen quality,increase 2PN fertilization and high-quality embryo rates,and is associated with a favorable safety profile.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(82000721)
更新日期/Last Update: 2026-02-04