[1]杨依琳,杨开艳,蒋姝亭.钼靶X射线联合血清TPS、MFG-E8对乳腺癌的诊断及预后预测价值[J].陕西医学杂志,2026,(2):230-234.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.015]
　YANG Yilin,YANG Kaiyan,JIANG Shuting.Diagnostic and prognostic predictive value of mammographic X-ray combined with serum TPS and MFG-E8 in breast cancer[J].,2026,(2):230-234.[doi:DOI:10.3969/j.issn.1000-7377.2026.02.015]
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钼靶X射线联合血清TPS、MFG-E8对乳腺癌的诊断及预后预测价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2026年2期
页码:
230-234
栏目:
临床研究
出版日期:
2026-02-05

文章信息/Info

Title:
Diagnostic and prognostic predictive value of mammographic X-ray combined with serum TPS and MFG-E8 in breast cancer
作者:
杨依琳; 杨开艳; 蒋姝亭
（常州市妇幼保健院 常州医学中心 南京医科大学，江苏 常州 213000）
Author(s):
YANG Yilin; YANG Kaiyan; JIANG Shuting
(Changzhou Maternal and Child Health Care Hospital,Changzhou Medical Center,Nanjing Medical University,Changzhou 213000,China)
关键词:
乳腺癌; 钼靶X射线; 组织多肽特异性抗原; 乳脂球表皮生长因子8; 诊断; 预后
Keywords:
Breast cancer; Mammographic X-ray; Tissue polypeptide specific antigen; Milk fat globule epidermal growth factor 8; Diagnosis; Prognosis
分类号:
R 737.9
DOI:
DOI:10.3969/j.issn.1000-7377.2026.02.015
文献标志码:
A
摘要:
目的：探讨钼靶X射线联合血清组织多肽特异性抗原（TPS）、乳脂球表皮生长因子8（MFG-E8）对乳腺癌（BC）的诊断及预后预测价值。方法：选取105例乳腺肿块患者，根据病理检查结果将其分为良性病变组（40例）和BC组（65例），同时选取同期健康女性80例为对照组。以Kappa检验分析钼靶X射线检查与病理诊断结果的一致性。比较三组血清TPS、MFG-E8水平。随访1年，记录患者死亡、复发或转移情况，并分为预后良好组（53例）和预后不良组（12例）。比较不同预后BC患者钼靶X射线恶性特征及血清TPS、MFG-E8水平。绘制受试者工作特征（ROC）曲线分析钼靶X射线检查、血清TPS及MFG-E8对BC的诊断及预后预测价值。结果：钼靶X射线检查结果显示，105例乳腺肿块患者中，乳腺恶性病变63例，良性病变42例。钼靶X射线检查与病理诊断结果的Kappa值为0.642（P＜0.05）。BC组血清TPS、MFG-E8水平高于良性病变组与对照组（均P＜0.05）。钼靶X射线检查、血清TPS及MFG-E8联合诊断BC的敏感度、特异度、阳性预测值、阴性预测值、准确率高于三项指标单独诊断（均P＜0.05）。预后不良组钼靶X射线显示恶性特征比例及血清TPS、MFG-E8水平高于预后良好组（均P＜0.05）。钼靶X射线检查、血清TPS及MFG-E8联合预测BC患者预后的敏感度、特异度、阳性预测值、阴性预测值、准确率高于三项指标单独预测（均P＜0.05）。结论：钼靶X射线检查联合血清TPS、MFG-E8对BC有一定的诊断及预后预测价值。
Abstract:
Objective:To evaluate the diagnostic and prognostic predictive value of mammographic X-ray combined with serum tissue polypeptide specific antigen (TPS) and milk fat globule epidermal growth factor 8 (MFG-E8) in breast cancer (BC).Methods：A total of 105 patients with breast masses were enrolled and divided into a benign lesion group (40 cases) and a BC group (65 cases) based on pathological findings.Eighty healthy women served as the control group.Concordance between mammographic X-ray and pathological diagnosis was assessed using the Kappa test.Serum levels of TPS and MFG-E8 were compared across the three groups.Patients were followed up for 1 year,and outcomes were recorded.Based on the occurrence of death,recurrence,or metastasis,BC patients were further classified into a favorable prognosis group (53 cases) and a poor prognosis group (12 cases).Malignant mammographic features and serum TPS and MFG-E8 levels were compared between prognostic subgroups.The ROC curve was drawn to analyze the diagnostic and prognostic predictive value of mammography X-ray examination,serum TPS and MFG-E8 for BC.Results:Mammographic X-ray identified 63 malignant and 42 benign lesions among the 105 breast mass patients.The Kappa value for agreement between mammographic and pathological findings was 0.642 (P<0.05).Serum TPS and MFG-E8 levels in the BC group were significantly higher than those in the benign lesion and control groups (all P<0.05).The combined use of mammographic X-ray,serum TPS,and MFG-E8 yielded superior sensitivity,specificity,positive predictive value,negative predictive value,and overall accuracy in diagnosing BC compared with each modality alone (all P<0.05).The proportion of malignant features shown by mammography X-ray and the levels of serum TPS and MFG-E8 in the poor prognosis group were higher than those in the good prognosis group (all P<0.05).The combined prediction of mammography X-ray examination,serum TPS and MFG-E8 for the prognosis of BC patients had higher sensitivity,specificity,positive predictive value,negative predictive value and accuracy than the prediction of any one of the three indicators alone (all P<0.05).Conclusion:The combination of mammographic X-ray with serum TPS and MFG-E8 offers valuable diagnostic and prognostic information in BC.

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备注/Memo

备注/Memo:
江苏省卫生健康委员会医学科学研究课题（BJ2024-13652）
更新日期/Last Update: 2026-02-04