[1]黄燕云,任策,时岩,等.βⅡ血影蛋白在心血管疾病中的研究进展[J].陕西医学杂志,2025,54(7):997-1000.[doi:DOI:10.3969/j.issn.1000-7377.2025.07.025]
　HUANG Yanyun,REN Ce,SHI Yan,et al.Research Progress on Spectrin-βⅡ in Cardiovascular Diseases[J].,2025,54(7):997-1000.[doi:DOI:10.3969/j.issn.1000-7377.2025.07.025]
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βⅡ血影蛋白在心血管疾病中的研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年7期
页码:
997-1000
栏目:
综 述
出版日期:
2025-07-05

文章信息/Info

Title:
Research Progress on Spectrin-βⅡ in Cardiovascular Diseases
作者:
黄燕云1; 任策2; 时岩1; 张广平2; 谢华宁2
(1.陕西中医药大学，陕西 咸阳 712000；2.陕西省中医医院心内科，陕西 西安710003)
Author(s):
HUANG Yanyun1; REN Ce2; SHI Yan1; ZHANG Guangping2; XIE Huaning2
(1.Shaanxi University of Chinese Medicine，Xianyang 712000，China；2.Department of Cardiology,Shaanxi Provincial Hospital of Traditional Chinese，Xi’an 710003，China)
关键词:
βⅡ血影蛋白; 分子结构; 生理功能; 功能障碍; 心血管疾病
Keywords:
Spectrin-βⅡ; Molecular structure; Physiological function; Dysfunction; Cardiovascular diseases
分类号:
R 543
DOI:
DOI:10.3969/j.issn.1000-7377.2025.07.025
文献标志码:
A
摘要:
βⅡ血影蛋白（Spectrin-βⅡ）是一种广泛表达的蛋白质，具有多种功能。其突变和功能障碍会影响器官的正常生长和发育。它已成为维持正常心脏膜兴奋性、机械功能和正常胚胎发生的关键蛋白。在心血管疾病的发生发展的重要性逐渐被重视。本综述重点论述了Spectrin-βⅡ的分子结构及功能障碍在心血管疾病中的潜在影响，以及未来治疗靶点研究的突出问题。
Abstract:
Spectrin-βⅡ is a widely expressed protein with multiple functions.Its mutations and dysfunctions can affect the normal growth and development of organs.It has become a critical protein in maintaining normal cardiac membrane excitability，mechanical function，and normal embryogenesis.The importance of Spectrin-βⅡ in the development and progression of cardiovascular diseases is gradually being recognized.This review focuses on the potential impact of Spectrin-βⅡ dysfunction in cardiovascular diseases and highlights the prominent issues in future research on therapeutic targets.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(82070867)；陕西省卫生健康科研基金资助项目(2021D033）；西安市科技计划科研基金资助项目（22YXYJ0109）
更新日期/Last Update: 2025-07-07