[1]魏亚宁,甄鹤,刘德华,等.胃癌组织TANK结合激酶1表达水平与临床病理的关系分析[J].陕西医学杂志,2025,54(7):993-996.[doi:DOI:10.3969/j.issn.1000-7377.2025.07.024]
　WEI Yaning,ZHEN He,LIU Dehua,et al.Relationship between expression level of TBK1 in gastric cancer tissues and clinicopathology[J].,2025,54(7):993-996.[doi:DOI:10.3969/j.issn.1000-7377.2025.07.024]
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胃癌组织TANK结合激酶1表达水平与临床病理的关系分析

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年7期
页码:
993-996
栏目:
临床病理
出版日期:
2025-07-05

文章信息/Info

Title:
Relationship between expression level of TBK1 in gastric cancer tissues and clinicopathology
作者:
魏亚宁1; 甄鹤2; 刘德华2; 李文文1
(1.河北大学附属医院肿瘤内科 河北省肿瘤放化疗机制与规程研究重点实验室，河北 保定 071000；2.河北大学附属医院 临床医学院，河北 保定 071000)
Author(s):
WEI Yaning1; ZHEN He2; LIU Dehua2; LI Wenwen1
(1.Department of Medical Oncology,Affiliated Hospital of Hebei University,Hebei Provincial Key Laboratory of Mechanism and Protocols of Cancer Radiotherapy and Chemotherapy,Baoding 071000,China;2.School of Clinical Medicine,Affiliated Hospital of Hebei University,Baoding 071000,China)
关键词:
胃癌; 癌组织; 癌旁组织; TBK1; 病理特征; ROC曲线; 生存率
Keywords:
Gastric cancer; Cancer tissues; Adjacent tissues; TBK1; Pathological characteristics; ROC curve; Survival rate
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2025.07.024
文献标志码:
A
摘要:
目的：探究胃癌组织TANK结合激酶1(TBK1)表达水平与临床病理的关系。方法：分析103例胃癌患者入院时癌组织及癌旁组织TANK结合激酶1(TBK1)表达水平。根据TBK1表达水平不同分为高表达组及低表达组，比较不同TBK1表达水平的胃癌患者入院时临床病理特征(肿瘤大小、肿瘤浸润深度、TNM分期、淋巴结转移、脉管侵犯、分化程度)，经ROC曲线评估胃癌患者临床病理特征对其癌组织TBK1表达的效能。结果：入院时，TBK1在胃癌患者癌组织表达水平显著高于癌旁组织的表达水平(0.49±0.08，P＜0.05)。高表达组肿瘤≥5 cm占比(53.45%)、肿瘤浸润深度T3级占比(60.34%)、TNM分期Ⅲ期占比(58.62%)、淋巴结转移占比(62.07%)均显著高于低表达组的26.67%、35.56%、31.11%、42.22%(均P＜0.05)。ROC曲线结果显示，胃癌患者癌组织临床病理特征对TBK1表达的评估效能的AUC值分别为0.634、0.624、0.638、0.599。结论：胃癌患者癌组织临床病理特征对TBK1表达具有一定的评估效能，且临床病理特征明显的胃癌患者通常TBK1表达水平较高。
Abstract:
Objective:To investigate the relationship of expression level of TANK-binding kinase 1(TBK1) in gastric cancer tissues with clinicopathology.Methods：The expression levels of TBK 1 in cancer tissues and adjacent tissues at admission were analyzed among 103 patients with gastric cancer.According to the different expression levels of TBK1，they were divided into high expression group and low expression group.The clinicopathological characteristics(tumor size，tumor invasion depth，TNM staging，lymph node metastasis，vascular invasion，differentiation degree) at admission were compared among gastric cancer patients with different TBK1 expression levels.ROC curve was used to evaluate the efficiency of clinicopathological characteristics of gastric cancer patients on the expression of TBK1 in cancer tissues.Results:At admission，the expression level of TBK1 in cancer tissues of patients with gastric cancer was significantly higher than that in adjacent tissues (0.49±0.08，P＜0.05).The proportions of tumor≥5 cm(53.45%)，tumor invasion depth T3(60.34%)，TNM stage Ⅲ(58.62%) and lymph node metastasis(62.07%) in high expression group were significantly higher than 26.67%，35.56%，31.11% and 42.22% in low expression group(all P＜0.05).ROC curve results showed that the AUCs of clinicopathological characteristics of gastric cancer tissues in evaluating the efficiency of TBK1 expression were 0.634，0.624，0.638 and 0.599 respectively.Conclusion:The clinicopathological characteristics of cancer tissues in patients with gastric cancer have certain evaluative efficiency on TBK1 expression，and gastric cancer patients with obvious clinicopathological characteristics usually have high TBK1 expression level.

参考文献/References:

[1]陈实，彭俊生.《腹腔镜胃癌根治术消化道重建相关并发症防治中国专家共识(2022版)》解读[J].中华胃肠外科杂志，2023，26(2)：121-125.
[2]中国抗癌协会胃癌专业委员会，中国医师协会外科医师分会上消化道外科医师专家工作组，中国老年保健协会消化系统疾病诊疗分会，等.胃癌肝转移诊断与综合治疗中国专家共识(2024版)[J].中国实用外科杂志，2024，44(5)：481-489.
[3]申沐穹，丁强，刘梅.混合型胃癌的预后与内镜治疗策略[J].中华消化内镜杂志，2024，41(2)：97-101.
[4]李睿，邵爽，孟玮，等.RNA结合蛋白Aly/REF输出因子通过上调Yes相关蛋白表达促进胃癌细胞的增殖和迁移[J].中国生物化学与分子生物学报，2023，39(4)：622-630.
[5]中国抗癌协会胃癌专业委员会，梁寒，徐惠绵，等.2024版CACA胃癌整合诊治指南(精简版)[J].中国肿瘤临床，2024，51(13)：650-657.
[6]陈红男,张思若,段宝军,等.晚期胃癌患者血清miR-191、miR-425表达水平与XELOX化疗敏感性的关系[J].保健医学研究与实践,2024,21(10):93-98.
[7]王卫卫，邢文韬，张爱青，等.血管内皮生长因子、程序性死亡受体-1联合胃功能三项对早期胃癌的诊断及预后评估价值[J].陕西医学杂志，2024，53(12)：1663-1667，1672.
[8]SUNG H，FERLAY J，SIEGEL R L，et al.Global cancer statistics 2020：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin，2021，71(3)：209-249.
[9]NIU P，ZHANG F，MA D，et al.Trends of older gastric cancer incidence，mortality，and survival in the highest gastric cancer risk area in China：2010-2019 and prediction to 2024[J].BMC Public Health,2024,24(1)：2449.
[10]刘殿波，钱远宇，张七斤，等.抗病毒天然免疫通路中IRF-3调控新机制[J].中国生物化学与分子生物学报，2009，25(12)：1090-1095.
[11]刘敏婷，文哲瑶，文思颖，等.高糖通过激活干扰素基因刺激因子通路导致视网膜血管内皮细胞炎症和紧密连接受损的机制研究[J].中华糖尿病杂志，2024，16(11)：1255-1264.
[12]李嘉，温本，颜倩英，等.乳腺癌改良根治术后感染患者外周血STING、TBK1、STAT6表达及意义[J].中华医院感染学杂志，2023，33(17)：2683-2687.
[13]ZHANG N，GAO Y，ZENG Z，et al.PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer[J].Clin Transl Oncol，2021，23(9)：1827-1837.
[14]国家卫生健康委员会.胃癌诊疗规范(2018年版)[J].中华消化病与影像杂志:电子版，2019，9(3)：118-144.
[15]王卫卫，邢文韬，张爱青，等.血管内皮生长因子、程序性死亡受体-1联合胃功能三项对早期胃癌的诊断及预后评估价值[J].陕西医学杂志，2024，53(12)：1663-1667,1672.
[16]张琳，郭珊岚，康乐平.胃癌组织MutS同源物6、减数分裂后分离增强基因2表达与幽门螺杆菌感染及预后相关性研究[J].陕西医学杂志，2025，54(3)：408-412.
[17]豆鹏程，舒劲，杨丽霞，等.基于细胞自噬理论探析胃癌的中医药防治机制[J].中华中医药学刊，2022，40(1)：126-129.
[18]MA X，JIA S，WANG G，et al.TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance[J].Signal Transduct Target Ther，2023，8(1)：246.
[19]SUN Y，REVACH O Y，ANDERSON S，et al.Targeting TBK1 to overcome resistance to cancer immunotherapy[J].Nature，2023，615(7950)：158-167.
[20]LEE S E，HONG M，CHO J，et al.IKKε and TBK1 expression in gastric cancer[J].Oncotarget，2017，8(10)：16233-16242.
[21]XIE X，ZHANG D，ZHAO B，et al.IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation[J].Proc Natl Acad Sci U S A，2011，108(16)：6474-6479.
[22]YU J，ZHOU X，CHANG M，et al.Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation[J].Nat Commun，2015，6：6074.
[23]KORHERR C，GILLE H，SCHAFER R，et al.Identification of proangiogenic genes and pathways by high-throughput functional genomics：TBK1 and the IRF3 pathway[J].Proc Natl Acad Sci U S A，2006，103(11)：4240-4245.
[24]CUI K，ZHANG S，LIU X，et al.Inhibition of TBK1 reduces choroidal neovascularization in vitro and in vivo[J].Biochem Biophys Res Commun，2018，503(1)：202-208.

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备注/Memo

备注/Memo:
河北省医学科学研究计划项目(20231965);河北大学医学学科培育项目（2024A021）；河北大学附属医院青年科研基金资助项目（2023QA08）
更新日期/Last Update: 2025-07-07