[1]刘光林,蒋佳伶,黄丹,等.HDAC7调控恶性肿瘤作用及机制研究进展[J].陕西医学杂志,2025,54(6):852-855,封3.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.025]
　LIU Guanglin,JIANG Jialing,HUANG Dan,et al.Research progress on role and mechanism of histone deacetylase 7 in regulating malignant tumors[J].,2025,54(6):852-855,封3.[doi:DOI:10.3969/j.issn.1000-7377.2025.06.025]
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HDAC7调控恶性肿瘤作用及机制研究进展

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
54
期数:
2025年6期
页码:
852-855,封3
栏目:
综 述
出版日期:
2025-06-05

文章信息/Info

Title:
Research progress on role and mechanism of histone deacetylase 7 in regulating malignant tumors
作者:
刘光林1; 2; 蒋佳伶1; 2; 黄丹3; 闫小龙1; 2
（1.陕西中医药大学第二临床医学院，陕西 咸阳 712046；2.空军军医大学唐都医院胸外科，陕西 西安 710038；3.解放军西部战区总医院干部三科，四川 成都 610083）
Author(s):
LIU Guanglin1; 2; JIANG Jialing1; 2; HUANG Dan3; YAN Xiaolong1; 2
(1.The Second Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,China;2.Department of Thoracic Surgery,Tangdu Hospital,Air Force Medical University,Xi’an 710038,China;3.The Third Department of Cadres,General Hospital of Western Theater Command,PLA,Chengdu 610083,China)
关键词:
恶性肿瘤; 组蛋白去乙酰化酶7; 非小细胞肺癌; 食管鳞状细胞癌; 胃癌; 肝细胞癌; 结直肠癌; 乳腺癌
Keywords:
Malignant tumors; Histone deacetylase 7; Non-small cell lung cancer; Esophageal squamous cell carcinoma; Gastric cancer; Hepatocellular carcinoma; Colorectal cancer; Breast cancer
分类号:
R 73
DOI:
DOI:10.3969/j.issn.1000-7377.2025.06.025
文献标志码:
A
摘要:
组蛋白去乙酰化酶7（HDAC7）作为组蛋白去乙酰化酶家族中关键成员，其表达失调与多种恶性肿瘤的疾病进展密切相关。因此，HDAC7被视为预测恶性肿瘤发生与发展的潜力生物学标志物，得到了国内外广泛关注。现对与HDAC7相关的最新肿瘤学研究进行总结，对HDAC7与恶性肿瘤的关系进行梳理，着重讨论HDAC7在非小细胞肺癌、食管癌、胃癌、肝细胞癌、胰腺癌、结直肠癌、胶质瘤、鼻咽癌、乳腺癌、白血病等恶性肿瘤中的调控作用及机制，为未来研究HDAC7及其潜在靶点对恶性肿瘤的影响提供最新理论依据。
Abstract:
Histone deacetylase 7(HDAC7) is a key member of the histone deacetylase family,and its dysregulated expression is closely related to the progression of various malignant tumors.Therefore,HDAC7 is regarded as a potential biological marker for predicting the progression of malignant tumors,and has received widespread attention both at home and abroad.This article summarizes the latest oncology research related to HDAC7,sorts out the relationship between HDAC7 and malignant tumors,and focuses on the regulatory role and mechanism of HDAC7 in non-small cell lung cancer,esophageal cancer,gastric cancer,hepatocellular carcinoma,pancreatic cancer,colorectal cancer,glioma,nasopharyngeal carcinoma,breast cancer,leukemia,in order to provides the latest theoretical basis for studying the effect of HDAC7 and its potential targets on malignant tumors in the future.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82173252）
更新日期/Last Update: 2025-06-04